UFP-101

发表于由

UFP-101;

UFP-101 是一种有效、选择性和竞争性的 NOP 受体拮抗剂，pKi 为 10.24。UFP-101 对 δ、μ 和 κ 类阿片受体的选择性大于 3000 倍。UFP-101 具有抗抑郁药样作用。

UFP-101amp;;

UFP-101 Chemical Structure

CAS No. : 849024-68-6

规格 是否有货
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UFP-101 的其他形式现货产品:

UFP-101 TFA

生物活性

UFP-101 is a potent, selective, and competitive antagonist of the NOP receptor, with a pKi of 10.24. UFP-101 displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 shows antidepressant-like effect[1][2].

体内研究
(In Vivo)

UFP-101 elicits a pronounced acute and dosedependent antidepressant-like effect in mice submitted to the forced swimming test (FST)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1908.17

Formula

C82H138N32O21
CAS 号

849024-68-6
Sequence Shortening

Bn-GGGFTGARKSARKRKNQ-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Calo G, et al. [Nphe1,Arg14,Lys15]nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor. Br J Pharmacol. 2002;136(2):303-311.

    [2]. Gavioli EC, et al. Blockade of nociceptin/orphanin FQ-NOP receptor signalling produces antidepressant-like effects: pharmacological and genetic evidences from the mouse forced swimming test. Eur J Neurosci. 2003;17(9):1987-1990.