VPM peptide

发表于2024年10月9日由Whatman官网

VPM peptide;

VPM peptide 是一种二硫醇蛋白酶可裂解的肽交联剂。VPM peptide 可掺入到 PEG-diacrylate (PEG-DA) 大分子单体的主链中以形成 PEG 水凝胶。

VPM peptide Chemical Structure

CAS No. : 1428885-83-9

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生物活性

VPM peptide is a dithiol protease-cleavable peptide cross-linker. VPM peptide can be incorporated into the backbone of the PEG-diacrylate (PEG-DA) macromer to form PEG hydrogel^[1]^[2].

体外研究
(In Vitro)

VPM peptide is rapidly cleaved by matrix metalloproteinase (MMP)-1 and MMP-2 proteases^[2].
VPM-crosslinked microgels are degradable by proteases in a concentration-dependent manner^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1696.95

Formula

C₆₃H₁₀₉N₂₅O₂₂S₄

CAS 号

1428885-83-9

Sequence Shortening

GCRDVPMSMRGGDRCG

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Phelps EA, et, al. Maleimide cross-linked bioactive PEG hydrogel exhibits improved reaction kinetics and cross-linking for cell encapsulation and in situ delivery. Adv Mater. 2012 Jan 3;24(1):64-70, 2

[2]. Foster GA, et, al. Protease-degradable microgels for protein delivery for vascularization. Biomaterials. 2017 Jan;113:170-175.

VPM peptide TFA

发表于2024年8月10日由Whatman官网

VPM peptide TFA;

VPM peptide TFA 是一种二硫醇蛋白酶可裂解的肽交联剂。VPM peptide TFA 可掺入到 PEG-diacrylate (PEG-DA) 大分子单体的主链中以形成 PEG 水凝胶。

VPM peptide TFA Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;