Urocortin 品牌：Anygen

发表于2024年9月29日由Whatman官网

Urocortin

品牌：Anygen
CAS No.：
储存条件：-20℃
纯度：–

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
305-17993	–	0.5 mg	–	咨询	–	–

* 干冰运输、大包装及大批量的产品需酌情添加运输费用

* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Urocortin, rat TFA(Synonyms: Urocortin (Rattus norvegicus) (TFA) Rat urocortin TFA)

发表于2024年8月10日由Whatman官网

Urocortin, rat TFA;(Synonyms: Urocortin (Rattus norvegicus) (TFA); Rat urocortin TFA)

Urocortin, rat TFA (Urocortin (Rattus norvegicus) TFA) 是一种神经肽，也是一种有效的内源性 CRFR 激动剂，对人 CRF₁，大鼠 CRF_2α 和小鼠 CRF_2β 的 K_i 分别为 13 nM，1.5 nM 和 0.97 nM。

Urocortin, rat TFAamp;;(Synonyms: Urocortin (Rattus norvegicus) (TFA); Rat urocortin TFA)

Urocortin, rat TFA Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性	Urocortin, rat TFA (Urocortin (Rattus norvegicus) TFA) is a neuropeptide and a potent endogenous CRFR agonist with K_is of 13 nM, 1.5 nM, and 0.97 nM for human CRF₁, rat CRF_2α and mouse CRF_2β, respectively^[1]^[2].
IC₅₀ Target	Ki: 13 nM (Human CRF₁), 1.5 nM (Rat CRF_2α), and 0.97 nM (Mouse CRF_2β)^[1]
体外研究 (In Vitro)	Urocortin, rat induces cyclic AMP (cAMP) generation with EC₅₀ of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF₁, rat CRF_2α and mouse CRF_2β, respectively in stably transfected Chinese hamster ovary cells^[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)	Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat i.c.v. administration. Urocortin, rat has the potential of inducing anxiogenic behavior^[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	4821.28
Formula	C₂₀8H_{3₃₉N₆₂F₃O₆₆}
Sequence Shortening	DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Perrin MH, et al. Corticotropin releasing factor receptors and their ligand family. Ann N Y Acad Sci. 1999 Oct 20;885:312-28. [2]. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33. [3]. Skelton KH, et al. The neurobiology of urocortin. Regul Pept. 2000 Sep 25;93(1-3):85-92.

Urocortin II, human TFA

发表于2024年8月3日由Whatman官网

Urocortin II, human TFA;

Urocortin II, human (TFA) 是一种选择性的 2 型促肾上腺皮质激素释放因子 (CRF2) 受体内源性多肽激动剂，用于研究 CRF2 受体在摄食行为中的作用。

Urocortin II, human TFA Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性	Urocortin II, human (TFA) is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. For investigating the role of the CRF (2) receptor in ingestive behavior^[1].
IC₅₀ Target	CRF2^[1]
分子量	4564.30
Formula	C₁₉₆H₃₄₀F₃N₆₃O₅₆S
Sequence Shortening	IVLSLDVPIGLLQILLEQARARAAREQATTNARILARVGHC-NH2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Zorrilla EP,et al. Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity. J Pharmacol Exp Ther. 2004 Sep;310(3):1027-34.

Urocortin III, mouse

发表于2024年7月5日由Whatman官网

Urocortin III, mouse;

Urocortin III, mouse 是促肾上腺皮质激素释放因子 (CRF) 的相关肽。Urocortin III 优先结合并激活 CRF-R2。Urocortin III (Ucn3) 是行为压力反应体系的一种的已知组分。Urocortin III 和 CRF-R2 存在于大脑杏仁核中，可调节复杂的社会动力学行为。

Urocortin III, mouse Chemical Structure

CAS No. : 357952-10-4

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

Urocortin III, mouse 的其他形式现货产品:

Urocortin III, mouse TFA

生物活性

Urocortin III, mouse is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2^[1]. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics^[2].

分子量

4172.97

Formula

C₁₈₆H₃₁₂N₅₂O₅₂S₂

CAS 号

357952-10-4

Sequence

Phe-Thr-Leu-Ser-Leu-Asp-Val-Pro-Thr-Asn-Ile-Met-Asn-Ile-Leu-Phe-Asn-Ile-Asp-Lys-Ala-Lys-Asn-Leu-Arg-Ala-Lys-Ala-Ala-Ala-Asn-Ala-Gln-Leu-Met-Ala-Gln-Ile-NH2

Sequence Shortening

FTLSLDVPTNIMNILFNIDKAKNLRAKAAANAQLMAQI-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7570-5. Lewis K, et al. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.

[2]. Shemesh Y, et al. Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics. Nat Neurosci. 2016 Nov;19(11):1489-1496.

Urocortin II, human

发表于2024年6月29日由Whatman官网

Urocortin II, human;

Urocortin II (human) 是一种选择性的 2 型促肾上腺皮质激素释放因子 (CRF2) 受体内源性多肽激动剂，用于研究 CRF2 受体在摄食行为中的作用。

Urocortin II, human Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性	Urocortin II (human) is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. For investigating the role of the CRF (2) receptor in ingestive behavior^[1].
IC₅₀ Target	CRF2^[1]
分子量	4450.28
Formula	C₁₉₄H₃₃₉N₆₃O₅₄S
Sequence Shortening	IVLSLDVPIGLLQILLEQARARAAREQATTNARILARVGHC-NH2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Zorrilla EP,et al. Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity. J Pharmacol Exp Ther. 2004 Sep;310(3):1027-34.

Urocortin III, mouse TFA

发表于2024年4月4日由Whatman官网

Urocortin III, mouse TFA; 纯度: 99.56%

Urocortin III, mouse TFA 是促肾上腺皮质激素释放因子 (CRF) 的相关肽。Urocortin III 优先结合并激活 CRF-R2。Urocortin III (Ucn3) 是行为压力反应体系的一种的已知组分。Urocortin III 和 CRF-R2 存在于大脑杏仁核中，可调节复杂的社会动力学行为。

Urocortin III, mouse TFA Chemical Structure

规格	价格	是否有货	数量
1 mg	￥2000	In-stock
5 mg	￥5000	In-stock
10 mg	￥8500	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

Urocortin III, mouse TFA 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Peptide Library

生物活性

Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2^[1]. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics^[2].

分子量

4286.99

Formula

C₁₈₈H₃₁₃N₅₂F₃O₅₄S₂

Sequence

Phe-Thr-Leu-Ser-Leu-Asp-Val-Pro-Thr-Asn-Ile-Met-Asn-Ile-Leu-Phe-Asn-Ile-Asp-Lys-Ala-Lys-Asn-Leu-Arg-Ala-Lys-Ala-Ala-Ala-Asn-Ala-Gln-Leu-Met-Ala-Gln-Ile-NH2

Sequence Shortening

FTLSLDVPTNIMNILFNIDKAKNLRAKAAANAQLMAQI-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80deg;C	2 years
	-20deg;C	1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:;

H₂O : 25 mg/mL (5.83 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2333 mL	1.1663 mL	2.3326 mL
5 mM	0.0467 mL	0.2333 mL	0.4665 mL
10 mM	—	—	—

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

参考文献

[1]. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7570-5. Lewis K, et al. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.

[2]. Shemesh Y, et al. Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics. Nat Neurosci. 2016 Nov;19(11):1489-1496.

Urocortin (Human) 品牌：Peptide

发表于2023年12月13日由Whatman官网

Urocortin (Human)

品牌：Peptide
CAS No.：176591-49-4
储存条件：-20℃
纯度：–

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
339-43281	–	0.1mg	–	咨询	–	–

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标签归档：urocortin

Urocortin 品牌：Anygen

Urocortin

Urocortin, rat TFA(Synonyms: Urocortin (Rattus norvegicus) (TFA) Rat urocortin TFA)

Urocortin II, human TFA

Urocortin III, mouse

Urocortin II, human

Urocortin III, mouse TFA

Urocortin III, mouse TFA 相关产品

bull;相关化合物库:

Urocortin (Human) 品牌：Peptide

Urocortin (Human)

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