Prosaptide Tx14(A) TFA

Prosaptide Tx14(A) TFA;

Prosaptide Tx14(A) TFA 是一种 prosaposin 衍生肽,是一种有效的 GPR37L1GPR37 激动剂,EC50 分别为 5 和 7 nM。Prosaptide Tx14(A) TFA 增加 Schwann 细胞 ERK1 和 ERK2 的磷酸化。

Prosaptide Tx14(A) TFAamp;;

Prosaptide Tx14(A) TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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Prosaptide Tx14(A) TFA 的其他形式现货产品:

Prosaptide Tx14(A)

生物活性

Prosaptide Tx14(A) TFA, a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells[1][2].

体外研究
(In Vitro)

Prosaptide Tx14(A) TFA promotes the endocytosis of GPR37 and GPR37L1, bound to both receptors and activated signaling in a GPR37- and GPR37L1-dependent manner. Prosaptide Tx14(A) TFA is the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also known as sulfated glycoprotein-1)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1693.72

Formula

C71H111F3N16O28

Sequence

Thr-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr

Sequence Shortening

TALIDNNATEEILY

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Meyer RC, et al. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc Natl Acad Sci U S A. 2013;110(23):9529-9534.

    [2]. Campana WM, et al. Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. FASEB J. 1998;12(3):307-314.

Anti-Fcα/μR, Mouse-Mono(TX57) 品牌:Transgenic


Anti-Fcα/μR, Mouse-Mono(TX57)

品牌:Transgenic
CAS No.:
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

KO571

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* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

Prosaptide Tx14(A)

Prosaptide Tx14(A); 纯度: 98.35%

Prosaptide Tx14(A) 是一种 prosaposin 衍生肽,是一种有效的 GPR37L1GPR37 激动剂,EC50 分别为 5 和 7 nM。Prosaptide Tx14(A) 增加 Schwann 细胞 ERK1 和 ERK2 的磷酸化。

Prosaptide Tx14(A)amp;;

Prosaptide Tx14(A) Chemical Structure

CAS No. : 196391-82-9

规格 价格 是否有货 数量
1 mg ¥1600 In-stock
5 mg ¥4000 In-stock
10 mg ¥6000 In-stock
25 mg ¥9800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Prosaptide Tx14(A) 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Prosaptide Tx14(A), a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) increases both ERK1 and ERK2 phosphorylation in Schwann cells[1][2].

体外研究
(In Vitro)

Prosaptide Tx14(A) promotes the endocytosis of GPR37 and GPR37L1, bound to both receptors and activated signaling in a GPR37- and GPR37L1-dependent manner. Prosaptide Tx14(A) is the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also known as sulfated glycoprotein-1)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1579.70

Formula

C69H110N16O26

CAS 号

196391-82-9

Sequence

Thr-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr

Sequence Shortening

TALIDNNATEEILY

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : ≥ 100 mg/mL (63.30 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6330 mL 3.1652 mL 6.3303 mL
5 mM 0.1266 mL 0.6330 mL 1.2661 mL
10 mM 0.0633 mL 0.3165 mL 0.6330 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (1.58 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.5 mg/mL (1.58 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Meyer RC, et al. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc Natl Acad Sci U S A. 2013;110(23):9529-9534.

    [2]. Campana WM, et al. Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. FASEB J. 1998;12(3):307-314.

Anti-Fcα/μR, Mouse-Mono(TX61) 品牌:Transgenic


Anti-Fcα/μR, Mouse-Mono(TX61)

品牌:Transgenic
CAS No.:
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

KO572

50 ug 咨询


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。