标签归档：tumulosic

Tumulosic acid(Synonyms: 土莫酸)

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上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Tumulosic acid (Synonyms: 土莫酸)

Tumulosic acid 是一种三萜类物质，可抑制 KLK5 蛋白酶活性 (IC50=14.84 μM)。Tumulosic acid 在体外抑制角质形成细胞中 LL-37 的蛋白水解过程 (≤10 μM)。

Tumulosic acid(Synonyms: 土莫酸)

Tumulosic acid Chemical Structure

CAS No. : 508-24-7

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生物活性

Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM[1].

体外研究
(In Vitro)

Tumulosic acid displays dose-dependent anti-KLK5 activity (IC50=19.3 μM)[1].
Tumulosic acid decreases in LL-37 production in human keratinocytes[1].
Tumulosic acid shows IC50 values of 14.84 and 10.48 μM against KLK5 and trypsin proteases, while it exhibited a weak inhibitory effect on KLK7 and chymotrypsin C proteases (19.5% and 4.0%, respectively, at 100 μM)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Normal human epidermal keratinocytes (NHEKs)
Concentration: 1 μM and 10 μM
Incubation Time: 23 h in the presence of 10 μM cycloheximide
Result: Decreased LL-37 production in epidermal keratinocytes.

分子量

486.73

Formula

C31H50O4
CAS 号

508-24-7
中文名称

土莫酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Matsubara Y, et al. Inhibition of Human Kallikrein 5 Protease by Triterpenoids from Natural Sources. Molecules. 2017;22(11):1829. Published 2017 Oct 27.