标签归档：tp

TP508

发表于由

TP508;

TP508 是一种 23 个氨基酸的非蛋白水解凝血酶肽，代表凝血酶分子受体结合结构域的一部分。TP508 可激活内皮 NO synthase (eNOS) 并刺激人内皮细胞中 NO 的产生。TP508 通过激活内皮细胞和干细胞以使血管再生和组织再生。

TP508amp;;

TP508 Chemical Structure

CAS No. : 121341-81-9

规格 价格 是否有货
1 mg ￥1200 询问价格 货期
5 mg ￥4800 询问价格 货期

* Please select Quantity before adding items.

TP508 的其他形式现货产品:

TP508 TFA

生物活性

TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 activates endothelial cells and stem cells to revascularize and regenerate tissues[1][2].

体外研究
(In Vitro)

TP508 (50 μg/mL; 24 hours; HCAEC) treatment reverses radiation-induced endothelial dysfunction (ED) and loss of NO signaling by attenuating the downregulation of eNOS expression. TP508 treatment is able to stimulate NO production in the irradiated cells[1].
TP508 mitigates effects of nuclear radiation on human endothelial cells in culture restoring endothelial NO production, tube formation and accelerating repair of radiation-induced DNA double-strand breaks (DSB)[1].
TP508 acts as an antagonist for the effects of thrombin. TP508 peptide inhibits these thrombin-induced effects through a RGD and αvβ3-related mechanism[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Primary human coronary artery endothelial cells (HCAEC)
Concentration: 50 μg/mL
Incubation Time: 24 hours
Result: Prevented the radiation-induced downregulation of eNOS.

体内研究
(In Vivo)

TP508 (10 mg/kg; intravenous injection; male CD-1 mice) treatment mitigates radiation-induced endothelial cell damage, also significantly increases survival of CD-1 mice when injected 24 h after 8.5 Gy exposure[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-1 mice (12-15-week old) with γ irradiation[1]
Dosage: 10 mg/kg
Administration: Intravenous injection
Result: Mitigated radiation-induced endothelial cell damage, also significantly increased survival of CD-1 mice.

Clinical Trial

分子量

2312.44

Formula

C97H146N28O36S
CAS 号

121341-81-9
Sequence

Ala-Gly-Tyr-Lys-Pro-Asp-Glu-Gly-Lys-Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val
Sequence Shortening

AGYKPDEGKRGDACEGDSGGPFV
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Olszewska-Pazdrak B, et al. Nuclear Countermeasure Activity of TP508 Linked to Restoration of Endothelial Function and Acceleration of DNA Repair. Radiat Res. 2016 Aug;186(2):162-74.

    [2]. Olszewska-Pazdrak B, et al. Systemic administration of thrombin peptide TP508 enhances VEGF-stimulated angiogenesis and attenuates effects of chronic hypoxia. J Vasc Res. 2013;50(3):186-9

    [3]. Tsopanoglou NE, et al. On the mode of action of thrombin-induced angiogenesis: thrombin peptide, TP508, mediates effects in endothelial cells via alphavbeta3 integrin. Thromb Haemost. 2004 Oct;92(4):846-57.

丹佛天平TP-213(毫克级天平)

发表于由

丹佛天平TP-213(毫克级天平)

产品型号： TP-213 品  牌： 丹佛Denver
丹佛天平TP-213(毫克级天平)，精密天平，外校式电子天平、千分之一天平(又称千分之一克天平或3位天平)，赛多利斯天平同生产线。丹佛天平TP-213属于TP便携系列，部分型号可选择电池供电, 便于户外携带使用。
型号        量程      可读性          称盘尺寸         重复性           线性                  平均响应时间
TP-213  210g       1mg           Φ90mm       ≤±0.1mg   ≤±0.2mg           — 
Denver丹佛精密天平TP-213，TP系列便携式天平,有以下技术特色：
◇特制纯铝防风罩背板,全面提升天平的防静电能力   
◇四重智能数字滤波   
◇全自动外校
◇触感反馈式按键
◇全程温度补偿   
◇全自动故障诊断   
◇超载保护   
◇双级一体传感器   
◇应用程序：计数、动物称重、百分比称重、净重求和、单位转换 
◇超大背光LCD显示屏，简洁的英文提示菜单   
◇内置RS232接口，符合GLP标准   
◇水平支脚和水平仪，确保天平稳定；水平气泡前置，方便调节水平 
◇下部吊钩，满足大体积称量   
◇不锈钢称量，方便清洗   
◇保修期一年

丹佛TP-214分析天平

发表于由

丹佛TP-214分析天平

产品型号： TP-214 品  牌： 丹佛Denver
丹佛TP-214分析天平，外校式电子天平、万分之一天平(又称万分之一克天平)，赛多利斯BSA224S孪生产品。TP-214属于TP便携系列，部分型号可选择电池供电, 便于户外携带使用。
型号        量程      可读性          称盘尺寸         重复性           线性                  平均响应时间
TP-214  210g       0.1mg         Φ90mm      ≤±0.1mg   ≤±0.2mg           — 
Denver丹佛电子天平TP-214，TP系列便携式天平,有以下技术特色：
◇特制纯铝防风罩背板,全面提升天平的防静电能力   
◇四重智能数字滤波   
◇全自动外校
◇触感反馈式按键
◇全程温度补偿   
◇全自动故障诊断   
◇超载保护   
◇双级一体传感器   
◇应用程序：计数、动物称重、百分比称重、净重求和、单位转换 
◇超大背光LCD显示屏，简洁的英文提示菜单   
◇内置RS232接口，符合GLP标准   
◇水平支脚和水平仪，确保天平稳定；水平气泡前置，方便调节水平 
◇下部吊钩，满足大体积称量   
◇不锈钢称量，方便清洗   
◇保修期一年

TP508 TFA

发表于由

TP508 TFA; 纯度: 99.79%

TP508 TFA 是一种 23 个氨基酸的非蛋白水解凝血酶肽，代表凝血酶分子受体结合结构域的一部分。TP508 TFA 可激活内皮 NO synthase (eNOS) 并刺激人内皮细胞中 NO 的产生。TP508 TFA 通过激活内皮细胞和干细胞以使血管再生和组织再生。

TP508 TFA 

TP508 TFA Chemical Structure

规格 价格 是否有货 数量
5 mg ￥3500 In-stock
10 mg ￥5500 In-stock
50 mg ￥16500 In-stock
100 mg ; 询价 ;
200 mg ; 询价 ;

* Please select Quantity before adding items.

TP508 TFA 相关产品

•相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

TP508 TFA is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 TFA activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 TFA activates endothelial cells and stem cells to revascularize and regenerate tissues[1][2].

体外研究
(In Vitro)

TP508 (50 μg/mL; 24 hours; HCAEC) treatment reverses radiation-induced endothelial dysfunction (ED) and loss of NO signaling by attenuating the downregulation of eNOS expression. TP508 treatment is able to stimulate NO production in the irradiated cells[1].
TP508 mitigates effects of nuclear radiation on human endothelial cells in culture restoring endothelial NO production, tube formation and accelerating repair of radiation-induced DNA double-strand breaks (DSB)[1].
TP508 acts as an antagonist for the effects of thrombin. TP508 peptide inhibits these thrombin-induced effects through a RGD and αvβ3-related mechanism[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Primary human coronary artery endothelial cells (HCAEC)
Concentration: 50 μg/mL
Incubation Time: 24 hours
Result: Prevented the radiation-induced downregulation of eNOS.

体内研究
(In Vivo)

TP508 (10 mg/kg; intravenous injection; male CD-1 mice) treatment mitigates radiation-induced endothelial cell damage, also significantly increases survival of CD-1 mice when injected 24 h after 8.5 Gy exposure[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-1 mice (12-15-week old) with γ irradiation[1]
Dosage: 10 mg/kg
Administration: Intravenous injection
Result: Mitigated radiation-induced endothelial cell damage, also significantly increased survival of CD-1 mice.

Clinical Trial

分子量

2426.46

Formula

C99H147N28F3O38S
Sequence

Ala-Gly-Tyr-Lys-Pro-Asp-Glu-Gly-Lys-Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val
Sequence Shortening

AGYKPDEGKRGDACEGDSGGPFV
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 50 mg/mL (20.61 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.4121 mL 2.0606 mL 4.1212 mL
5 mM 0.0824 mL 0.4121 mL 0.8242 mL
10 mM 0.0412 mL 0.2061 mL 0.4121 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Olszewska-Pazdrak B, et al. Nuclear Countermeasure Activity of TP508 Linked to Restoration of Endothelial Function and Acceleration of DNA Repair. Radiat Res. 2016 Aug;186(2):162-74.

    [2]. Olszewska-Pazdrak B, et al. Systemic administration of thrombin peptide TP508 enhances VEGF-stimulated angiogenesis and attenuates effects of chronic hypoxia. J Vasc Res. 2013;50(3):186-9

    [3]. Tsopanoglou NE, et al. On the mode of action of thrombin-induced angiogenesis: thrombin peptide, TP508, mediates effects in endothelial cells via alphavbeta3 integrin. Thromb Haemost. 2004 Oct;92(4):846-57.

丹佛天平TP-313(毫克级天平)

发表于由

丹佛天平TP-313(毫克级天平)

产品型号： TP-313 品  牌： 丹佛Denver
丹佛天平TP-313(毫克级天平)，精密天平，外校式电子天平、千分之一天平(又称千分之一克天平或3位天平)，赛多利斯天平同生产线。丹佛天平TP-313属于TP便携系列，部分型号可选择电池供电, 便于户外携带使用。
型号        量程      可读性          称盘尺寸         重复性           线性                  平均响应时间
TP-313  310g       1mg           Φ90mm       ≤±0.1mg   ≤±0.2mg           — 
Denver丹佛精密天平TP-313，TP系列便携式天平,有以下技术特色：
◇特制纯铝防风罩背板,全面提升天平的防静电能力   
◇四重智能数字滤波   
◇全自动外校◇触感反馈式按键
◇全程温度补偿   
◇全自动故障诊断   
◇超载保护   
◇双级一体传感器   
◇应用程序：计数、动物称重、百分比称重、净重求和、单位转换 
◇超大背光LCD显示屏，简洁的英文提示菜单   
◇内置RS232接口，符合GLP标准   
◇水平支脚和水平仪，确保天平稳定；水平气泡前置，方便调节水平 
◇下部吊钩，满足大体积称量   
◇不锈钢称量，方便清洗   
◇保修期一年

丹佛TP-114分析天平

发表于由

丹佛TP-114分析天平

产品型号： TP-114 品  牌： 丹佛Denver
丹佛TP-114分析天平，外校式电子天平、万分之一天平(又称万分之一克天平)，赛多利斯BSA124S孪生产品。TP-114属于TP便携系列，部分型号可选择电池供电, 便于户外携带使用。
型号        量程      可读性          称盘尺寸         重复性           线性                  平均响应时间
TP-114  110g       0.1mg         Φ90mm      ≤±0.1mg   ≤±0.2mg           — 
Denver丹佛电子天平TP-114，TP系列便携式天平,有以下技术特色：
◇特制纯铝防风罩背板,全面提升天平的防静电能力   
◇四重智能数字滤波   
◇全自动外校
◇触感反馈式按键
◇全程温度补偿   
◇全自动故障诊断   
◇超载保护   
◇双级一体传感器   
◇应用程序：计数、动物称重、百分比称重、净重求和、单位转换 
◇超大背光LCD显示屏，简洁的英文提示菜单   
◇内置RS232接口，符合GLP标准   
◇水平支脚和水平仪，确保天平稳定；水平气泡前置，方便调节水平 
◇下部吊钩，满足大体积称量   
◇不锈钢称量，方便清洗   
◇保修期一年

Nordic-MUbio T100P Sheep anti Human Fli-1 250 µg

发表于由

上海金畔生物科技有限公司提供Nordic-MUbio T100P Sheep anti Human Fli-1 250 µg，欢迎访问官网了解更多产品信息和订购

品牌 货号 产品名称 规格 价格

Nordic-MUbio T100P Sheep anti Human Fli-1 250 µg 4179.00

Nordic-MUbio T100MS Mouse anti Human LEF-1 beta catenin 100 µg 4179.00

Nordic-MUbio T100M Mouse anti Human LEF-1 beta catenin 250 µg 6699.00

Nordic-MUbio X1507P Rabbit anti Human Calcium Channel 100 µg 4179.00

Nordic-MUbio X1506P Rabbit anti Rat Calcium Channel 100 µg 4179.00

Nordic-MUbio X1505P Rabbit anti Rat Potassium Channel 100 µg 4179.00

Nordic-MUbio X1504P Rabbit anti Rat Kv3.1b Potassium Channel 100 µg 4179.00

Nordic-MUbio S135P Rabbit anti Mouse Nephronophthisis (pic) 250 µg 4179.00

Nordic-MUbio S130P Sheep anti Human Myeloid Tumor Gene Related 1 (MTGR1) 250 µg 4179.00

Nordic-MUbio S125P Sheep anti Rat SSeCKS – myristylated (PKC) substrate 250 µg 4179.00

Nordic-MUbio S120P Sheep anti Human Vav-2 DPH 250 µg 4179.00

Nordic-MUbio S115P Sheep anti Human Vav-2 SHD 250 µg 4179.00

Nordic-MUbio S110P Sheep anti Human ELK rec tyr Kinase (Eph B1 Cy.) 250 µg 4179.00

Nordic-MUbio S105P Sheep anti Human ELK rec tyr Kinase (Eph B1 SAM.) 250 µg 4179.00

Nordic-MUbio S100P Sheep anti Human ELK rec tyr Kinase (Eph B1 Ext.) 250 µg 4179.00

Nordic-MUbio P225P Sheep anti Human Protein Phosphatase V/C (PP6C) 100 µg 4179.00

Nordic-MUbio P220P Rabbit anti Human Protein Phosphatase V/C (PP6C) 100 µg 4179.00

Nordic-MUbio P215P Rabbit anti Human Protein Phosphatase 4 R1 (X/A’2) 100 µg 4179.00

Nordic-MUbio P210P Sheep anti Human Protein Phosphatase 4 R1 (X/A) 100 µg 4179.00

Nordic-MUbio P205P Sheep anti Human Protein Phosphatase 2 C alpha/beta 100 µg 4179.00

Nordic-MUbio T5208p Rabbit anti Indole-3-butyric acid 1 ml

发表于由

上海金畔生物科技有限公司提供Nordic-MUbio T5208p Rabbit anti Indole-3-butyric acid 1 ml，欢迎访问官网了解更多产品信息和订购

品牌 货号 产品名称 规格 价格

Nordic-MUbio T5208p Rabbit anti Indole-3-butyric acid 1 ml 5733.00

Nordic-MUbio T0158p Chicken anti Indole-3-butyric acid 1 ml 6279.00

Nordic-MUbio S52s Sheep anti Atrazine 0.1 ml 5733.00

Nordic-MUbio S52p Sheep anti Atrazine 0.5 ml 5733.00

Nordic-MUbio M80s Rabbit anti Naproxen 0.1 ml 5733.00

Nordic-MUbio M80p Rabbit anti Naproxen 0.5 ml 5733.00

Nordic-MUbio M51s Rabbit anti Ibuprofen 0.1 ml 5733.00

Nordic-MUbio M51pA Rabbit anti Ibuprofen 1 ml 5733.00

Nordic-MUbio M51p Rabbit anti Ibuprofen 0.5 ml 5733.00

Nordic-MUbio M46s Rabbit anti Clofibrate 0.1 ml 5733.00

Nordic-MUbio M46p Rabbit anti Clofibrate 0.5 ml 5733.00

Nordic-MUbio M35s Rabbit anti Alkylphenols (nonylphenol; octylphenol) 0.1 ml 5733.00

Nordic-MUbio M35p Rabbit anti Alkylphenols (nonylphenol; octylphenol) 0.5 ml 5733.00

Nordic-MUbio M33p Rabbit anti Alkylphenols (nonylphenol; octylphenol) 0.5 ml 5733.00

Nordic-MUbio K67s Rabbit anti Bisphenol A 0.1 ml 5733.00

Nordic-MUbio K66s Rabbit anti Bisphenol A 0.1 ml 5733.00

Nordic-MUbio K66p Rabbit anti Bisphenol A 0.5 ml 5733.00

Nordic-MUbio K40s Rabbit anti Fenitrothion 0.1 ml 5733.00

Nordic-MUbio J49s Rabbit anti Pirimiphos 0.1 ml 5733.00

Nordic-MUbio J49p Rabbit anti Pirimiphos 0.5 ml 5733.00

Anti Mouse TP Polyclonal Antibody 品牌：Medicinal Chemistry Pharmaceuticals

发表于由

Anti Mouse TP Polyclonal Antibody

品牌：Medicinal Chemistry Pharmaceuticals
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

309-93331

 – 25ug – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Anti-TP, Rabbit-Poly 品牌：Transgenic

发表于由

Anti-TP, Rabbit-Poly

品牌：Transgenic
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

KO578

 – 25 ug – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。