Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model^[1].

Super-TDU downregulates expression of YAP-TEADs target genes CTGF, CYR61, and CDX2. Super-TDU inhibits cell viability and colony formation of GC cell lines MGC-803, BGC-823, and HGC27^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Super-TDU (intravenous injection; 50 μg/kg or 500 μg/kg; per day) markedly decreases the sizes, weights of tumors, and YAP target genes in a dose-dependent manner in mice^[1].
Super-TDU (intravenous injection; 250 μg/kg 500 μg/kg) has the t_1/2α of 0.78 hours and 0.82 hours; the C_max of 6.12 ng/mL and 13.3 ng/mL; the CL of 7.41 ml/min/kg and 7.72 ml/min/kg for 250 μg/kg and 500 μg/kg in mice, respectively^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

5279.94

C₂₃₇H₃₇₀N₆₆O₆₉S

1599441-71-0

SVDDHFAKSLGDTWLQIGGSGNPKTANVPQTVPMRLRKLPDSFFKPPE

Room temperature in continental US; may vary elsewhere.

H₂O : 50 mg/mL (9.47 mM; Need ultrasonic)

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储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

• [1]. Jiao S, et al. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell. 2014 Feb 10;25(2):166-80.