标签归档：swertiajaponin

Swertiajaponin(Synonyms: 日当药黄素)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Swertiajaponin;(Synonyms: 日当药黄素)

Swertiajaponin 是一种酪氨酸酶抑制剂，与酪氨酸酶结合囊形成多个氢键和疏水相互作用，IC50 值为 43.47 μM。Swertiajaponin 还能通过抑制氧化应激介导的 MAPK/MITF 信号导致酪氨酸酶蛋白水平下降。Swertiajaponin 能抑制黑色素积累，具有较强的抗氧化活性。

Swertiajaponin(Synonyms: 日当药黄素)

Swertiajaponin Chemical Structure

CAS No. : 6980-25-2

规格 价格 是否有货 数量
1 mg ￥2290 In-stock
5 mg ￥6860 In-stock
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Swertiajaponin 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC50 of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity[1].

IC50 Target

IC50: 43.47 μM (tyrosinase)[1]
分子量

462.40

Formula

C22H22O11
CAS 号

6980-25-2
中文名称

日当药黄素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)
参考文献

  • [1]. Lee B, et al. Swertiajaponin inhibits skin pigmentation by dual mechanisms to suppress tyrosinase. Oncotarget. 2017 Sep 15;8(56):95530-95541.