标签归档：spiraeoside

Spiraeoside(Synonyms: Quercetin 4′-O-glucoside)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Spiraeoside;(Synonyms: Quercetin 4′-O-glucoside)

Spiraeoside 是具有口服活性的天然产物，具有抗氧化活性，抑制活性氧和丙二醛的生成。Spiraeoside 具有抗过敏、抗炎、抗肿瘤活性。

Spiraeoside(Synonyms: Quercetin 4′-O-glucoside)

Spiraeoside Chemical Structure

CAS No. : 20229-56-5

规格 价格 是否有货
5 mg ￥5700 询问价格 货期
10 mg ￥9500 询问价格 货期

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生物活性

Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities[1].

体外研究
(In Vitro)

Spiraeoside elevates HG stimulation-caused the decrease in the expression levels of p-Akt, nuclear Nrf2, and HO-1 in AC16 cells (the effects of Spiraeoside are reversed by LY294002)[1].
Spiraeoside protects AC16 cells against HG-induced oxidative stress, cell injury, and apoptosis[1].
Spiraeoside activates the PI3K/Akt/Nrf2 pathway in AC16 cells on exposure to HG[1].
Spiraeoside protects AC16 cells against HG-induced apoptosis through the PI3K/Akt/Nrf2 pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: AC16 cells.
Concentration: 1, 5, 10, or 20 μM.
Incubation Time: 0, 24, or 48 hours.
Result: Inhibited AC16 cells viability (20 μM).

体内研究
(In Vivo)

Spiraeoside (50 mg/kg, p.o.) shows ulcer preventive ability[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (6-8 weeks old)[2].
Dosage: 50 mg/kg.
Administration: Oral gavage an hour before inducing the lesions.
Result: Decreased severity of the formed lesions.

分子量

464.38

Formula

C21H20O12
CAS 号

20229-56-5
中文名称

螺旋藻苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hongyang Liu, et al. Spiraeoside protects human cardiomyocytes against high glucose-induced injury, oxidative stress, and apoptosis by activation of PI3K/Akt/Nrf2 pathway. J Biochem Mol Toxicol. 2020 Oct;34(10):e22548.

    [2]. Stevan Samardžić, et al. Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench. J Ethnopharmacol. 2018 Mar 1;213:132-137.