天然产物 糖类和糖苷 Saccharides and Glycosides
Smilagenin; 纯度: ge;98.0%
Smilagenin (SMI) 是一种小分子甾体皂苷元，来自知母 Rhizoma anemarrhenae 和天竺葵 Radix asparagi，广泛用于慢性神经退行性疾病的研究。Smilagenin (SMI) 通过增加毒蕈碱受体亚型 1 (M1)-受体的的密度来改善老年大鼠的记忆。 Smilagenin (SMI) 通过刺激脑源性神经营养因子的基因表达减弱 Aβ (25-35) 诱导的神经变性，可用于 AD 的研究。
Smilagenin Chemical Structure
CAS No. : 126-18-1
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 10;mM;*;1 mL in DMSO | ￥880 | In-stock | |
| 5 mg | ￥800 | In-stock | |
| 10 mg | ￥1200 | In-stock | |
| 50 mg | ￥3500 | In-stock | |
| 100 mg | ￥5500 | In-stock | |
| 200 mg | ; | 询价 | ; |
| 500 mg | ; | 询价 | ; |
* Please select Quantity before adding items.
Smilagenin 相关产品
bull;相关化合物库:
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| 生物活性 |
Smilagenin (SMI) is a small-molecule steroidal sapogenin from Rhizoma anemarrhenae and Radix asparagi widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases[1]. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density[2]. Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD[3]. |
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| IC50 Target |
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| 体外研究 (In Vitro) |
Smilagenin (10 μM; 24 hours) increases SH-SY5Y cell survival compared with Aβ(25-35) intoxicated cells[3]. Smilagenin (10 μM; 24 hours) increases neurotrophic factor (GDNF) and neurotrophic factor (BDNF) mRNA level by promoting CREB phosphorylation in 1-methyl-4-phenylpyridimium (MPP+) treated SH-SY5Y cells[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[3]
RT-PCR[2]
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| 体内研究 (In Vivo) |
Smilagenin (intragastric administration; 10 or 26 mg/kg, once daily; 60 days) prevents the impairment of dopaminergic neurons in chronic MPTP/probenecid-induced mouse model[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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| 分子量 |
416.64 |
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| Formula |
C27H44O3 |
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| CAS 号 |
126-18-1 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 溶解性数据 |
In Vitro:;
Ethanol : ≥ 10 mg/mL (24.00 mM) DMSO : 5 mg/mL (12.00 mM; Need ultrasonic) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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| 参考文献 |
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