SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC₅₀ of 89 nM^[1]. SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor, with a K_i of 1 μM^[2].

IC50: 89 nM (RSK)^[1].
Ki: 1 μM (RSK1/2)^[2].

SL 0101-1 (SL0101) shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G₁ phase^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

516.45

C₂₅H₂₄O₁₂

77307-50-7

Room temperature in continental US; may vary elsewhere.

• [1]. Smith JA, et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 2005 Feb 1;65(3):1027-34.

  [2]. Yu Li, et al. The Affinity of RSK for Cylitol Analogues of SL0101 Is Critically Dependent on the B-ring C-4′-hydroxy. Chem Commun (Camb). 2020 Mar 10;56(20):3058-3060.