SKF 100398;(Synonyms: d(CH2)5Tyr(Et)VAVP)
SKF 100398 (d(CH2)5Tyr(Et)VAVP) 是一种精氨酸加压素 (AVP) 类似物,能作为外源性和内源性 AVP 抗利尿作用的特异性拮抗剂。
SKF 100398 Chemical Structure
CAS No. : 77453-01-1
规格 |
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是否有货 |
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100 mg |
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询价 |
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250 mg |
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询价 |
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500 mg |
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询价 |
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* Please select Quantity before adding items.
生物活性 |
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP[1].
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体内研究 (In Vivo) |
SKF 100398 is a specific antagonist of the hydrosmotic effect of exogenous and endogenous AVP[1]. SKF 100398 (8 μg/kg; i.v.) abolishes the antidiuretic effect of AVP[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: |
Male Sprague-Dawley rats (250-300 g)[1] |
Dosage: |
8 μg/kg |
Administration: |
Intravenous injection |
Result: |
Completely blocked the antidiuretic effect of exogenous AVP (4 ng/kg body wt i.v.). |
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分子量 |
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Formula |
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CAS 号 |
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Sequence |
{(1-Mercaptocyclohexyl)acetyl}-{Tyr(O-Ethyl)}-Phe-Val-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: 1-Cys6)
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Sequence Shortening |
{(1-Mercaptocyclohexyl)acetyl}-{Tyr(O-Ethyl)}-YFVNCPRG-NH2 (Disulfide bridge: 1-Cys6)
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运输条件 |
Room temperature in continental US; may vary elsewhere.
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储存方式 |
Powder |
-80deg;C |
2 years |
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-20deg;C |
1 year |
In solvent |
-80deg;C |
6 months |
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-20deg;C |
1 month |
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参考文献 |
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