[1]. Eva Tavčar Benković, et al. Identification, in vitro and in vivo Antioxidant Activity, and Gastrointestinal Stability of Lignans from Silver Fir (Abies alba) Wood Extract. Journal of Wood Chemistry and Technology. 2017 Jan, 467-477.
Secoisolariciresinol diglucoside Chemical Structure
CAS No. : 257930-74-8
规格
价格
是否有货
数量
10;mM;*;1 mL in Water
¥1209
In-stock
5 mg
¥800
In-stock
10 mg
¥1400
In-stock
25 mg
¥2800
In-stock
50 mg
¥3900
In-stock
100 mg
¥6700
In-stock
200 mg
;
询价
;
500 mg
;
询价
;
* Please select Quantity before adding items.
Secoisolariciresinol diglucoside 相关产品
bull;相关化合物库:
Natural Product Library Plus
Bioactive Compound Library Plus
Immunology/Inflammation Compound Library
Natural Product Library
Glycoside Compound Library
Anti-Cardiovascular Disease Compound Library
Phenols Library
Orally Active Compound Library
Neuroprotective Compound Library
Anti-Obesity Compound Library
生物活性
Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects[1][2].
体外研究 (In Vitro)
Secoisolariciresinol diglucoside (1-500 μM) possesses strong reducing power and high free radical scavenging activity for hydroxyl, peroxyl and DPPH free radicals[1]. Secoisolariciresinol diglucoside (1-50 μM; 24 h) attenuates human monocyte adhesion to and migration across human brain endothelial monolayers[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)
Secoisolariciresinol diglucoside (4 mg/mouse; a single p.o.) diminishes leukocyte adhesion and migration across blood-brain barrier (BBB) in neuroinflammation[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
Hand feeding mice (10 weeks old, male) are injected with TNFα[2]
Dosage:
4 mg/mouse
Administration:
P.o. 2 h before i.c. administration of TNFα
Result:
Attenuated adhesion of leukocytes to the endothelium by 50% and attenuated migration of leukocytes across the BBB by 64%.
分子量
686.70
Formula
C32H46O16
CAS 号
257930-74-8
中文名称
亚麻木酚素
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Mishra OP, et al. Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorg Med Chem Lett. 2013 Oct 1;23(19):5325-8.
[2]. Rom S, et, al. Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation. J Neuroinflammation. 2018 Jan 27;15(1):25.
(R,R)-Secoisolariciresinol diglucoside Chemical Structure
CAS No. : 158932-33-3
规格
价格
是否有货
数量
10;mM;*;1 mL in DMSO
¥755
In-stock
5 mg
¥500
In-stock
10 mg
¥800
In-stock
20 mg
¥1400
In-stock
50 mg
;
询价
;
100 mg
;
询价
;
* Please select Quantity before adding items.
(R,R)-Secoisolariciresinol diglucoside 相关产品
bull;相关化合物库:
Natural Product Library Plus
Bioactive Compound Library Plus
Immunology/Inflammation Compound Library
Natural Product Library
Glycoside Compound Library
Food-Sourced Compound Library
生物活性
(R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells[1][2][3].
分子量
686.70
Formula
C32H46O16
CAS 号
158932-33-3
中文名称
(R,R)-亚麻木酚素
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Mishra OP, et al. Novel synthetic (S,S) and (R,R)-secoisolariciresinol diglucosides (SDGs) protect naked plasmid and genomic DNA From gamma radiation damage. Radiat Res. 2014 Jul;182(1):102-10.
[2]. Mishra OP, et al. Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorg Med Chem Lett. 2013 Oct 1;23(19):5325-8.
[3]. Mishra OP, et al. Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits myeloperoxidase activity in inflammatory cells. Biochim Biophys Acta Gen Subj. 2018 Jun;1862(6):1364-1375.