3′,6-Disinapoylsucrose, the index component of Yuanzhi (Polygala tenuifolia Willd), possesses potent antioxidant activity and antidepressant effect[1][2].
分子量
754.69
Formula
C34H42O19
CAS 号
139891-98-8
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Tian Y, et al. Naturally Occurring Cinnamic Acid Sugar Ester Derivatives. Molecules. 2016 Oct 24;21(10).
[2]. Shi Q, et al. Indirect identification of antioxidants in Polygalae Radix through their reaction with 2,2-diphenyl-1-picrylhydrazyl and subsequent HPLC-ESI-Q-TOF-MS/MS. Talanta. 2015 Nov 1;144:830-5.
2′-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2′-Deoxyuridine is as a precursor in the synthesis of Edoxudine.
IC50 Target
Human Endogenous Metabolite
;
分子量
228.20
Formula
C9H12N2O5
CAS 号
951-78-0
运输条件
Room temperature in continental US; may vary elsewhere.
3′-Methoxypuerarin (3′-MOP) is an isoflavone extracted from radix puerariae that shows neuron protection activity.
体内研究 (In Vivo)
3′-Methoxypuerarin increases the number of surviving neurons in the hippocampal CA1 region and markedly reduces the number of apoptotic pyramidal neurons after ischemia/reperfusion injury. 3′-Methoxypuerarin can protect hippocampal neurons against I/R injury by inhibiting apoptosis[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
446.40
Formula
C22H22O10
CAS 号
117047-07-1
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4deg;C, sealed storage, away from moisture and light
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro:;
DMSO : 250 mg/mL (560.04 mM; Need ultrasonic)
配制储备液
浓度溶剂体积质量
1 mg
5 mg
10 mg
1 mM
2.2401 mL
11.2007 mL
22.4014 mL
5 mM
0.4480 mL
2.2401 mL
4.4803 mL
10 mM
0.2240 mL
1.1201 mL
2.2401 mL
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
[1]. Liu Y, et al. Protection by 3′-methoxypuerarin of rat hippocampal neurons against ischemia/reperfusion injury. Chin J Physiol. 2010 Apr 30;53(2):136-40.
Animal Administration [1]
Rats[1]
Male Wistar rats, weighing 260-320 g are randomly divided into three groups (n = 8 per group). [1] I/R+3′-MOP group: the rats undergo 8 minutes of ischemia and then 3 days of reperfusion. The 3′-Methoxypuerarin (60 mg/kg i.p.) is administrated at the moment of clamping of the carotid arteries. The rats receive daily i.p. injection of 3′-Methoxypuerarin for 3 days. [2] I/R group: the rats undergo 8 minutes of ischemia and 72 h of reperfusion. The same volume of solvent (35% polyethylene glycol solution) is administrated in the same way as 3′-Methoxypuerarin. [3] Control group: the rats undergo a sham operation. Vertebral and carotid arteries are exposed but not occluded. The rats receive a daily i.p. injection of 35% polyethylene glycol solution for 3 days[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献
[1]. Liu Y, et al. Protection by 3′-methoxypuerarin of rat hippocampal neurons against ischemia/reperfusion injury. Chin J Physiol. 2010 Apr 30;53(2):136-40.
Esculentoside H (EsH) 是从多年生植物 Phytolacca esculent 的根提取物中分离的一种皂苷。 Esculentoside H (EH) 具有抗肿瘤活性,其机制与 TNF 释放能力有关。 Esculentoside H (EsH) 通过阻断 JNK1/2 和 NF-κB 信号介导的基质金属蛋白酶-9 (MMP-9) 表达抑制结肠癌细胞迁移。
Esculentoside H Chemical Structure
CAS No. : 66656-92-6
规格
价格
是否有货
数量
5 mg
¥1500
In-stock
10 mg
¥2500
In-stock
50 mg
;
询价
;
100 mg
;
询价
;
* Please select Quantity before adding items.
Esculentoside H 相关产品
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生物活性
Esculentoside H (EsH) is a saponin isolated from the root extract of perennial plant Phytolacca esculenta[1]. Esculentoside H (EH) has anti-tumor activity, the mechanism is related to the capacity for TNFrelease[2]. Esculentoside H (EsH) suppresses colon cancer cell migration through blockage of the JNK1/2 and NF-κB signaling-mediated matrix metalloproteinases-9 (MMP-9) expression[1].
Clinical Trial
分子量
989.10
Formula
C48H76O21
CAS 号
66656-92-6
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Ha SH, et al. Esculentoside H inhibits colon cancer cell migration and growth through suppression of MMP-9 gene expression via NF-kB signaling pathway. J Cell Biochem. 2019 Jun;120(6):9810-9819.
[2]. Hu ZL, et al. Effect of esculentoside H on release of tumor necrosis factor from mouse peritoneal macrophages. Zhongguo Yao Li Xue Bao. 1993 Nov;14(6):550-2.
Kaempferol 3,4′-diglucoside is a flavonol isolated from the aqueous methanolic extract of norway spruce buds. Kaempferol 3,4′-diglucoside is identified in the needles[1].
IC50 Target[1]
Human Endogenous Metabolite
;
分子量
610.52
Formula
C27H30O16
CAS 号
71939-16-7
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Slimestad R., et al. Syringetin 3-O-(6″-acetyl)-β-glucopyranoside and other flavonols from needles of norway spruce, Picea abies. Phytochemistry. 1995;40(5):1537-1542.
Dactylorhin A 是从 Gymnadenia conopsea 根茎中分离得到的一种琥珀酸衍生物酯。Dactylorhin A 对 RAW 264.7 巨噬细胞产生 NO 有中等程度的抑制作用。
Dactylorhin A Chemical Structure
CAS No. : 256459-34-4
规格
价格
是否有货
5 mg
¥2500
询问价格 货期
* Please select Quantity before adding items.
生物活性
Dactylorhin A, a succinate derivative ester, is isolated from rhizomes of Gymnadenia conopsea. Dactylorhin A exhibits moderate inhibitory effects on NO production effects in RAW 264.7 macrophage cells[1][2].
分子量
888.86
Formula
C40H56O22
CAS 号
256459-34-4
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Cai M, et al. Chemical fingerprint analysis of rhizomes of Gymnadenia conopsea by HPLC-DAD-MSn. J Chromatogr B Analyt Technol Biomed Life Sci. 2006;844(2):301-307.
[2]. Zhao Y, et al. Chemical constituents from Bletilla striata and their NO production suppression in RAW 264.7 macrophage cells. J Asian Nat Prod Res. 2018;20(4):385-390.
6”-O-Acetylsaikosaponin A, an acetyl saikosaponin isolated from the roots of Bupleurum chinense, shows some osteoclast-inhibiting activities[1].
体外研究 (In Vitro)
The major bioactive compounds isolated from R. bupleuri are saikosaponins, which have been proved to possess significant biological activities, including anti-hepatitis, anti-inflammatory, anti-tumor and immunoregulatory effects[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
823.02
Formula
C44H70O14
CAS 号
64340-46-1
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Yu JQ, et al. Osteoclast-inhibiting saikosaponin derivatives from Bupleurum chinense. Fitoterapia. 2013;85:101-108.
[2]. Huang HQ, et al. Fast determination of saikosaponins in Bupleurum by rapid resolution liquid chromatography with evaporative light scattering detection. J Pharm Biomed Anal. 2009;49(4):1048-1055.