Ginsenoside Rg3 人参皂甙Rg3 品牌：Chemodex

20(S)-Ginsenoside Rg3 是红参的主要成分。20(S)-Ginsenoside Rg3 抑制 Na⁺ 和 hKv1.4 通道，IC₅₀ 分别为 32.2±4.5 和 32.6±2.2 μM。20(S)-Ginsenoside Rg3 还抑制 Aβ，NF-κB 活性和 COX-2 表达。

20(S)-Ginsenoside Rg3 Chemical Structure

CAS No. : 14197-60-5

规格	价格	是否有货	数量
10;mM;*;1 mL in DMSO	￥563	In-stock
10 mg	￥512	In-stock
50 mg	￥1097	In-stock
100 mg	￥1953	In-stock
200 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

20(S)-Ginsenoside Rg3 相关产品

bull;相关化合物库:

Natural Product Library Plus
Drug Repurposing Compound Library Plus
FDA-Approved Drug Library Plus
FDA-Approved Drug Library Mini
Bioactive Compound Library Plus
Immunology/Inflammation Compound Library
Membrane Transporter/Ion Channel Compound Library
Metabolism/Protease Compound Library
Neuronal Signaling Compound Library
NF-kappa;B Signaling Compound Library
Stem Cell Signaling Compound Library
Natural Product Library
FDA-Approved Drug Library
Anti-Cancer Compound Library
Human Endogenous Metabolite Compound Library
Anti-Aging Compound Library
Drug Repurposing Compound Library
Antioxidants Compound Library
Differentiation Inducing Compound Library
Glycoside Compound Library
Lipid Compound Library
Oxygen Sensing Compound Library
Anti-COVID-19 Compound Library
NMPA-Approved Drug Library
Medicine Food Homology Compound Library
Terpenoids Library
Pyroptosis Compound Library
Traditional Chinese Medicine Monomer Library
FDA Approved amp; Pharmacopeial Drug Library
Anti-Alzheimer’s Disease Compound Library
Neuroprotective Compound Library
Anti-Breast Cancer Compound Library
Anti-Pancreatic Cancer Compound Library
Anti-Blood Cancer Compound Library
Neurodegenerative Disease-related Compound Library
Anti-Obesity Compound Library
Transcription Factor Targeted Library
Food-Sourced Compound Library
Anti-Liver Cancer Compound Library
Anti-Colorectal Cancer Compound Library

生物活性

20(S)-Ginsenoside Rg3 is the main component of Red ginseng. Ginsenoside Rg3 inhibits Na⁺ and hKv1.4 channel with IC₅₀s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.

IC₅₀ Target

p65

;

COX-2

;

Human Endogenous Metabolite

;

Na⁺ channel

32.2 mu;M (IC₅₀)

hKv1.4 channel

32.6 mu;M (IC₅₀)

Aβ40

;

Aβ42

;

体外研究
(In Vitro)

Ginsenoside Rg3 plays an important role in its effect on the Na⁺ channel. Treatment with Ginsenoside Rg3 reversibly inhibits the inward Na+ peak current (INa) with an IC₅₀ of 32.2±4.5 μM, and the inhibition is voltage-dependent^[1]. Ginsenoside Rg3 at 100 μM inhibits the hKv1.4 channel currents by an average of 65%.The Ginsenoside Rg3 effect is concentration-dependent and reversible. The IC₅₀ value and Hill coefficient are 32.6±2.2 μM and 1.59±0.13, respectively^[2]. Ginsenoside Rg3 shows the significant inhibition of NF-κB activity thereby reduced COX-2 expression. To examine the cytotoxicity of Ginsenoside Rg3 on IL-1β-induced inflamed A549 cells, the cells are firstly treated with IL-1β (10 ng/mL) for 4 h and treated with 100 to 900 ng/mL concentration of Ginsenoside Rg3 for 12 h. Cell viability is analyzed using an MTT assay. There is no observed cytotoxicity of Ginsenoside Rg3 in IL-1β-induced inflamed A549 cells compared to only PBS-treated cells (Con).To obtain the anti-inflammatory effects of Ginsenoside Rg3 on inflammation induced human lung epithelial cells, A549 cells inflammation is induced by IL-1β (10 ng/mL) and then treated by 5 μM of Dexamethasone (Dex) or 900 nM of Rg3. The NF-κB activation is analyzed by a western blot analysis to evaluate the effect of Ginsenoside Rg3 treatment on A549 cells. Phospho-NF-κB p65/total NF-κB p65 densitometry in the cells treated with Rg3 shows the significant decrease compared to IL-1β-induced inflamed A549 cells. The meaning of reducing the ratio of p-p65/p65 by Rg3 treatment is associated with NF-κB activation. Ginsenoside Rg3 also downregulates the expression of COX-2 effectively^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Ginsenoside Rg3 ((20S)-Rg3) is an Aβ-lowering Natural Compound. APP/PS1 mice are treated with Ginsenoside Rg3 once a day for 4 weeks by intraperitoneal injection (10 mg/kg/day). Aβ ELISA analysis of brain tissues reveal that Ginsenoside Rg3 treatment results in a significant reduction of Aβ40 and Aβ42 in the brain^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

785.01

Formula

C₄₂H₇₂O₁₃

CAS 号

14197-60-5

中文名称

20(S)-人参皂苷 Rg3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20deg;C	3 years
	4deg;C	2 years
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : 100 mg/mL (127.39 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.2739 mL	6.3693 mL	12.7387 mL
5 mM	0.2548 mL	1.2739 mL	2.5477 mL
10 mM	0.1274 mL	0.6369 mL	1.2739 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (3.18 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.18 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.18 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.18 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.18 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.18 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Kim JH, et al. A role for the carbohydrate portion of ginsenoside Rg3 in Na⁺ channel inhibition. Mol Cells. 2005 Feb 28;19(1):137-42.

[2]. Lee JH, et al. Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue. Mol Pharmacol. 2008 Mar;73(3):619-26.

[3]. Lee IS, et al. Anti-Inflammatory Effects of Ginsenoside Rg3 via NF-κB Pathway in A549 Cells and Human Asthmatic Lung Tissue. J Immunol Res. 2016;2016:7521601.

[4]. Kang MS, et al. Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3. J Biol Chem. 2013 Jul 19;288(29):20868-82.

Cell Assay ^[3]	MTT assays are performed to evaluate the cytotoxicity of Ginsenoside Rg3 on inflamed cells. Ten thousands of A549 cells cultured each well of 96-well plate and are incubated at 37°C and 5% CO₂ overnight. After serum starvation using DMEM low glucose without FBS, the medium is changed into RPMI containing IL-1β (10 ng/mL) and the cells are incubated at 37°C and 5% CO₂ for 4 h. After 4 h incubation, the cells are treated with Ginsenoside Rg3 (100-900 nM) for 12 h. Thirty microliters of MTT solution (5 mg/mL) is added to each well and the cells are incubated for 2 h. After 2 h incubation in cell culture incubator, the medium containing MTT solution of each well is removed and 50 μL of DMSO is added. Using an automated spectrophotometric plate reader at 570 nm, the optical density of formazan is measured^[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[4]	Mice^[4] The mice used are heterozygous, double transgenic animals expressing both human APP(K670N/M671L) and PS1(M146L) proteins. These Alzheimer disease model mice are age-matched (3 months old) in all experiments with wild-type littermates. Both sets of mice are produced by crossing heterozygous APP mice with heterozygous PS1 mice and are weaned at 3 weeks and genotyped by PCR of digested tail samples. Ginsenoside Rg3 is prepared in a saline solution containing 0.01% DMSO at a concentration of 10 mg/kg of body weight. Ginsenoside Rg3 (or saline with 0.01% DMSO for controls) is administered daily via intraperitoneal injection. After sacrifice, one hemibrain from each mouse is frozen on dry ice, homogenized in sucrose buffer, and extracted via formic acid for Aβ quantification using a commercial sandwich ELISA kit. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Kim JH, et al. A role for the carbohydrate portion of ginsenoside Rg3 in Na⁺ channel inhibition. Mol Cells. 2005 Feb 28;19(1):137-42. [2]. Lee JH, et al. Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue. Mol Pharmacol. 2008 Mar;73(3):619-26. [3]. Lee IS, et al. Anti-Inflammatory Effects of Ginsenoside Rg3 via NF-κB Pathway in A549 Cells and Human Asthmatic Lung Tissue. J Immunol Res. 2016;2016:7521601. [4]. Kang MS, et al. Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3. J Biol Chem. 2013 Jul 19;288(29):20868-82.

Ginsenoside Rg1(Synonyms: 人参皂苷 Rg1; Panaxoside A; Panaxoside Rg1)

发表于2024年5月6日由Whatman官网

天然产物糖类和糖苷 Saccharides and Glycosides

Ginsenoside Rg1;(Synonyms: 人参皂苷 Rg1; Panaxoside A; Panaxoside Rg1) 纯度: ge;98.0%

Ginsenoside Rg1 是人参的主要活性成分之一。Ginsenoside Rg1 改善认知功能受损，通过降低大脑 Aβ 水平来发挥作用。Ginsenoside Rg1 减少 NF-κB 核易位。

Ginsenoside Rg1 Chemical Structure

CAS No. : 22427-39-0

规格	价格	是否有货	数量
Free Sample (0.1-0.5 mg)	;	Apply now	;
10;mM;*;1 mL in DMSO	￥1057	In-stock
5 mg	￥700	In-stock
10 mg	￥1200	In-stock
50 mg	￥3600	In-stock
100 mg	;	询价	;
200 mg	;	询价	;

* Please select Quantity before adding items.

Ginsenoside Rg1 相关产品

bull;相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Apoptosis Compound Library
Immunology/Inflammation Compound Library
Neuronal Signaling Compound Library
NF-kappa;B Signaling Compound Library
Stem Cell Signaling Compound Library
Natural Product Library
Anti-Cancer Compound Library
Anti-Aging Compound Library
Antioxidants Compound Library
Differentiation Inducing Compound Library
Glycoside Compound Library
Lipid Compound Library
Oxygen Sensing Compound Library
Medicine Food Homology Compound Library
Terpenoids Library
Pyroptosis Compound Library
Traditional Chinese Medicine Monomer Library
FDA Approved amp; Pharmacopeial Drug Library
Anti-Alzheimer’s Disease Compound Library
Anti-Breast Cancer Compound Library
Anti-Pancreatic Cancer Compound Library
Anti-Blood Cancer Compound Library
Neurodegenerative Disease-related Compound Library
Anti-Obesity Compound Library
Transcription Factor Targeted Library
Food-Sourced Compound Library
Anti-Liver Cancer Compound Library

生物活性

Ginsenoside Rg1 is one of the major active components of ginseng. Ginsenoside Rg1 ameliorates the impaired cognitive function, displays promising effects by reducing cerebral Aβ levels. Ginsenoside Rg1 also reduces NF-κB nuclear translocation.

IC₅₀ Target^[1]^[2]

Aβ_1-42

;

p65

;

体外研究
(In Vitro)

Ginsenoside Rg1 promotes the proliferation and differentiation of human dental pulp cells (hDPCs). The proliferative ability of hDPCs in Ginsenoside Rg1 is significantly enhanced (p<0.05), especially in the Ginsenoside Rg1 (5 μM) group. ALP activity and gene expressions of DSPP and DMP1 are increased in the induction group, Ginsenoside Rg1 group, and their combination group compared with the control group (p<0.05)^[3]. In the RAW264.7 cells stimulated by lipopolysaccharides (LPS) , the level of p-IκBα and p-p65 is significantly higher than in controls and PPAR-γ levels are significantly lower. Treatment with Rg1 vitro inhibits IκBα phosphorylation, reduces NF-κB nuclear translocation and upregulates PPAR-γ expression^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

In the inflamed joints of adjuvant-induced arthritis (AIA) rats, the level of p-IκBα and p-p65 is significantly higher than in controls and PPAR-γ levels are significantly lower. Treatment with Ginsenoside Rg1 in vivo inhibits IκBα phosphorylation, reduces NF-κB nuclear translocation and upregulates PPAR-γ expression^[2]. Ginsenoside Rg1 (G-Rg1) and Ginsenoside Rg2 (G-Rg2) reduce the escape latencies on the last two training days compared to the Alzheimer’s disease (AD) model group (p<0.05). In the spatial exploration test, the total time spent in the target quadrant and the number of mice that exactly crossed the previous position of the platform are clearly shorter and lower, respectively, in the AD model group mice than in the normal control group mice (p<0.01), a trend that is reversed by treatment with Ginsenoside Rg1 and Ginsenoside Rg2 (Ginsenoside Rg1, p<0.01; Ginsenoside Rg2, p<0.05). Treatment with Ginsenoside Rg1 and Ginsenoside Rg2 effectively improve cognitive function of the mice that have declined due to AD. Ginsenoside Rg1 and Ginsenoside Rg2 reduce Aβ_1-42 accumulation in APP/PS1 mice. In the Ginsenoside Rg1 and Ginsenoside Rg2 treated mice, the pathological abnormalities observed in the APP/PS1 mice are gradually ameliorated. Clear nucleoli and light brown, sparsely scattered Aβ deposits are visible^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

801.01

Formula

C₄₂H₇₂O₁₄

CAS 号

22427-39-0

中文名称

人参皂苷 Rg1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20deg;C	3 years
	4deg;C	2 years
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : ≥ 100 mg/mL (124.84 mM)

* “≥” means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.2484 mL	6.2421 mL	12.4842 mL
5 mM	0.2497 mL	1.2484 mL	2.4968 mL
10 mM	0.1248 mL	0.6242 mL	1.2484 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (3.12 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.12 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.12 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.12 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.12 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.12 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Li N, et al. A UPLC/MS-based metabolomics investigation of the protective effect of ginsenosides Rg1 and Rg2 in mice with Alzheimer’s disease. J Ginseng Res. 2016 Jan;40(1):9-17.

[2]. Wang P, et al. Effect of ginsenoside Rg1 on proliferation and differentiation of human dental pulp cells in vitro. Aust Dent J. 2012 Jun;57(2):157-65.

[3]. Zhang L, et al. Ginsenoside Rg1 attenuates adjuvant-induced arthritis in rats via modulation of PPAR-γ/NF-κB signal pathway. Oncotarget. 2017 Jul 24;8(33):55384-55393.

Cell Assay ^[3]	hDPCs are incubated with different concentrations of Ginsenoside Rg1 (0.1, 0.5, 2.5, 5, 10 and 20 μM) . The effects of Ginsenoside Rg1 on the proliferative ability of hDPCs are evaluated by a fibroblast colony forming test, MTT assay and flow cytometry for cell cycle. The control group, osteogenic induction group, Ginsenoside Rg1 (5 μM) group and combination group are designed, and alkaline phosphatase (ALP) activity and FQ-PCR for gene expressions of dentine sialophosphoprotein (DSPP) and dentine matrix protein 1 (DMP1) are performed to evaluate the differentiation of hDPCs^[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[1]	Mice^[1] Male APP/PS1 mice, weighing 20±2 g, and male C57BL/6J mice, weighing 20±2 g, are used. The animals are maintained in an air-conditioned animal center at 23±2°C and a relative humidity of 50±10%, with a natural light-dark cycle. Food and water are available ad libitum. After acclimatization for 1 wk, the mice are divided into four groups (n=10 in each group): the normal control group, the AD model group, the Ginsenoside Rg1 group, and the Ginsenoside Rg2 group. According to the concentration-response curves, the mice in the Ginsenoside Rg1 and Ginsenoside Rg2 groups are injected intraperitoneally once daily with Ginsenoside Rg1 and Ginsenoside Rg2 (30 mg/kg), respectively, dissolved in saline. The mice in the AD model group (APP/PS1 mice) and the normal control group (C57BL/6J nontransgenic littermates) are treated with isodose saline (0.9% w/v). All mice are treated for 1 mo before brain metabolite profiling. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Li N, et al. A UPLC/MS-based metabolomics investigation of the protective effect of ginsenosides Rg1 and Rg2 in mice with Alzheimer’s disease. J Ginseng Res. 2016 Jan;40(1):9-17. [2]. Wang P, et al. Effect of ginsenoside Rg1 on proliferation and differentiation of human dental pulp cells in vitro. Aust Dent J. 2012 Jun;57(2):157-65. [3]. Zhang L, et al. Ginsenoside Rg1 attenuates adjuvant-induced arthritis in rats via modulation of PPAR-γ/NF-κB signal pathway. Oncotarget. 2017 Jul 24;8(33):55384-55393.

(20R)-Ginsenoside Rg3(Synonyms: (20R)-人参皂苷Rg3; (20R)-Propanaxadiol; R-ginsenoside Rg3)

发表于2024年4月26日由Whatman官网

天然产物糖类和糖苷 Saccharides and Glycosides

(20R)-Ginsenoside Rg3;(Synonyms: (20R)-人参皂苷Rg3; (20R)-Propanaxadiol; R-ginsenoside Rg3) 纯度: ge;98.0%

(20R)-ginsenoside Rg3 ((20R)-Propanaxadiol)，人参根中的一种活性化合物，具有抑制血管内皮细胞增生（IC₅₀= 10 nM）和抗肿瘤活性。

(20R)-Ginsenoside Rg3 Chemical Structure

CAS No. : 38243-03-7

规格	价格	是否有货	数量
10;mM;*;1 mL in DMSO	￥691	In-stock
5 mg	￥500	In-stock
10 mg	￥800	In-stock
20 mg	￥1400	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

(20R)-Ginsenoside Rg3 相关产品

bull;相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Natural Product Library
Anti-Cancer Compound Library
Glycoside Compound Library
Medicine Food Homology Compound Library
Terpenoids Library
Traditional Chinese Medicine Monomer Library

生物活性

(20R)-ginsenoside Rg3 ((20R)-Propanaxadiol), one of the active compounds present in ginseng root, inhibits vascular endothelial growth factor (VEGF)(IC₅₀=10 nM) and antitumor activities^[1]^[2].

分子量

785.01

Formula

C₄₂H₇₂O₁₃

CAS 号

38243-03-7

中文名称

(20R)-人参皂苷Rg3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20deg;C	3 years
	4deg;C	2 years
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : 41.67 mg/mL (53.08 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.2739 mL	6.3693 mL	12.7387 mL
5 mM	0.2548 mL	1.2739 mL	2.5477 mL
10 mM	0.1274 mL	0.6369 mL	1.2739 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 4.17 mg/mL (5.31 mM); Clear solution

此方案可获得 ≥ 4.17 mg/mL (5.31 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 41.7 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Liu L, et al. Enzymatic preparation of 20(S, R)-protopanaxadiol by transformation of 20(S, R)-Rg3 from blackginseng. Phytochemistry. 2010 Sep;71(13):1514-20.

[2]. Yue PY, et al. The angiosuppressive effects of 20(R)- ginsenoside Rg3. Biochem Pharmacol. 2006 Aug 14;72(4):437-45.

Ginsenoside Rg6(Synonyms: 人参皂苷 Rg6)

发表于2024年4月25日由Whatman官网

天然产物糖类和糖苷 Saccharides and Glycosides

Ginsenoside Rg6;(Synonyms: 人参皂苷 Rg6) 纯度: 99.13%

Ginsenoside Rg6 在 HepG2 细胞中抑制 TNF-α 诱导的 NF-κB 转录活性， IC₅₀ 为 29.34 μM。Ginsenoside Rg6 还具有细胞凋亡诱导作用。

Ginsenoside Rg6 Chemical Structure

CAS No. : 147419-93-0

规格	价格	是否有货	数量
1 mg	￥1350	In-stock
5 mg	￥3400	In-stock
10 mg	;	询价	;
50 mg	;	询价	;

* Please select Quantity before adding items.

Ginsenoside Rg6 相关产品

bull;相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Apoptosis Compound Library
Immunology/Inflammation Compound Library
NF-kappa;B Signaling Compound Library
Stem Cell Signaling Compound Library
Natural Product Library
Anti-Cancer Compound Library
Anti-Aging Compound Library
Antioxidants Compound Library
Differentiation Inducing Compound Library
Glycoside Compound Library
Oxygen Sensing Compound Library
Terpenoids Library
Pyroptosis Compound Library
Anti-Breast Cancer Compound Library
Anti-Pancreatic Cancer Compound Library
Anti-Blood Cancer Compound Library
Anti-Obesity Compound Library
Transcription Factor Targeted Library
Food-Sourced Compound Library
Anti-Liver Cancer Compound Library

生物活性

Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC₅₀ of 29.34 μM in HepG2 cells. Ginsenoside Rg6 also exhibits apoptosis-inducing effect.

IC₅₀ Target^[1]^[2]

NF-κB

25.12 mu;M (IC₅₀, in SK-Hep1 cell)

NF-κB

29.34 mu;M (IC₅₀, in HepG2 cell)

Apoptosis

;

体外研究
(In Vitro)

Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC₅₀ of 25.12±1.04 μM in SK-Hep1 cells, consistent with the data from HepG2 cells^[1]. Ginsenoside Rg6 exhibits obvious anti-proliferative and apoptosis-inducing effects when it is applied to JK cells in vitro. Ginsenoside Rg6 blocks S arrest in the cell cycle. CCK-8 method shows that after Ginsenoside Rg6 is used, several groups with different concentrations obviously inhibits JK cell proliferation in human lymphocytoma, with evident dose dependency. Based on IC₅₀, the median inhibitory concentration of Ginsenoside Rg6 is 83.08 μM^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

767.00

Formula

C₄₂H₇₀O₁₂

CAS 号

147419-93-0

中文名称

人参皂苷 Rg6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据

In Vitro:;

DMSO : 100 mg/mL (130.38 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.3038 mL	6.5189 mL	13.0378 mL
5 mM	0.2608 mL	1.3038 mL	2.6076 mL
10 mM	0.1304 mL	0.6519 mL	1.3038 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (3.26 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.26 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.26 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.26 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.26 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.26 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Cho K, et al. Inhibition of TNF-α-Mediated NF-κB Transcriptional Activity by Dammarane-Type Ginsenosidesfrom Steamed Flower Buds of Panax ginseng in HepG2 and SK-Hep1 Cells. Biomol Ther (Seoul). 2014 Jan;22(1):55-61.

[2]. Chen B, et al. Apoptosis-inducing effect of ginsenoside Rg6 on human lymphocytoma JK cells. Molecules. 2013 Jul 9;18(7):8109-19.

Cell Assay ^[1]	HepG2 and SK-Hep1 cells are maintained in Dulbecco’s modified Eagle’s medium containing 10% heat-inactivated fetal bovine serum, 100 units/mL Penicillin, and 10 μg/mL Streptomycin, at 37°C and 5% CO₂. Cell-Counting Kit (CCK)-8is used to analyze the effect of compounds (e.g., Ginsenoside Rg6; 0.01, 0.1, 1 and 10 μM) on cell toxicity. Cells are cultured overnight in 96-well plate (~1×10⁴ cells/well). Cell toxicity is assessed after the addition of compounds on dose-dependent manner. After 24 h of treatment, 10 μL of the CCK-8 solution is added to triplicate wells, and incubated for 1 h. Absorbance is measured at 450 nm to determine viable cell numbers in wells^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Cho K, et al. Inhibition of TNF-α-Mediated NF-κB Transcriptional Activity by Dammarane-Type Ginsenosidesfrom Steamed Flower Buds of Panax ginseng in HepG2 and SK-Hep1 Cells. Biomol Ther (Seoul). 2014 Jan;22(1):55-61. [2]. Chen B, et al. Apoptosis-inducing effect of ginsenoside Rg6 on human lymphocytoma JK cells. Molecules. 2013 Jul 9;18(7):8109-19.

Cell Assay
^[1]

HepG2 and SK-Hep1 cells are maintained in Dulbecco’s modified Eagle’s medium containing 10% heat-inactivated fetal bovine serum, 100 units/mL Penicillin, and 10 μg/mL Streptomycin, at 37°C and 5% CO₂. Cell-Counting Kit (CCK)-8is used to analyze the effect of compounds (e.g., Ginsenoside Rg6; 0.01, 0.1, 1 and 10 μM) on cell toxicity. Cells are cultured overnight in 96-well plate (~1×10⁴ cells/well). Cell toxicity is assessed after the addition of compounds on dose-dependent manner. After 24 h of treatment, 10 μL of the CCK-8 solution is added to triplicate wells, and incubated for 1 h. Absorbance is measured at 450 nm to determine viable cell numbers in wells^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Cho K, et al. Inhibition of TNF-α-Mediated NF-κB Transcriptional Activity by Dammarane-Type Ginsenosidesfrom Steamed Flower Buds of Panax ginseng in HepG2 and SK-Hep1 Cells. Biomol Ther (Seoul). 2014 Jan;22(1):55-61.

[2]. Chen B, et al. Apoptosis-inducing effect of ginsenoside Rg6 on human lymphocytoma JK cells. Molecules. 2013 Jul 9;18(7):8109-19.

I-bu-rG Phosphoramidite

发表于2024年4月21日由Whatman官网

生化分析试剂 Biochemical Assay Reagents
I-bu-rG Phosphoramidite; 纯度: ge;98.0%

I-bu-rG Phosphoramidite 是一种亚磷酰胺单体，可用于核苷酸和核酸的合成。

I-bu-rG Phosphoramidite Chemical Structure

CAS No. : 147201-04-5

规格	价格	是否有货	数量
100 mg	￥500	In-stock
200 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

I-bu-rG Phosphoramidite 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus

生物活性

I-bu-rG Phosphoramidite is a phosphinamide monomer which can be used in the synthesis of nucleotides and nucleic acids.

分子量

970.18

Formula

C₅₀H₆₈N₇O₉PSi

CAS 号

147201-04-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20deg;C	3 years
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : 100 mg/mL (103.07 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.0307 mL	5.1537 mL	10.3074 mL
5 mM	0.2061 mL	1.0307 mL	2.0615 mL
10 mM	0.1031 mL	0.5154 mL	1.0307 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (2.58 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.58 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

Ginsenoside Rg5(Synonyms: 人参皂甙 Rg5)

发表于2024年4月19日由Whatman官网

天然产物糖类和糖苷 Saccharides and Glycosides

Ginsenoside Rg5;(Synonyms: 人参皂甙 Rg5) 纯度: 99.86%

Ginsenoside Rg5 是红参的主要成分。Ginsenoside Rg5 阻断 IGF-1 与其受体的结合，IC₅₀ 约为90 nM。Ginsenoside Rg5 还通过抑制 NF-κB p65 的 DNA 结合活性来抑制 COX-2 的 mRNA 表达。

Ginsenoside Rg5 Chemical Structure

CAS No. : 186763-78-0

规格	价格	是否有货	数量
10;mM;*;1 mL in DMSO	￥3797	In-stock
5 mg	￥2800	In-stock
10 mg	￥4500	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

Ginsenoside Rg5 相关产品

bull;相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Immunology/Inflammation Compound Library
Kinase Inhibitor Library
NF-kappa;B Signaling Compound Library
Protein Tyrosine Kinase Compound Library
Stem Cell Signaling Compound Library
Natural Product Library
Anti-Cancer Compound Library
Anti-Aging Compound Library
Antioxidants Compound Library
Differentiation Inducing Compound Library
Glycoside Compound Library
Oxygen Sensing Compound Library
Anti-Cardiovascular Disease Compound Library
Endocrinology Compound Library
Medicine Food Homology Compound Library
Terpenoids Library
Pyroptosis Compound Library
Traditional Chinese Medicine Monomer Library
Anti-Breast Cancer Compound Library
Anti-Pancreatic Cancer Compound Library
Anti-Blood Cancer Compound Library
Anti-Obesity Compound Library
Angiogenesis Related Compound Library
Transcription Factor Targeted Library
Anti-Liver Cancer Compound Library
Anti-Colorectal Cancer Compound Library

生物活性

Ginsenoside Rg5 is the main component of Red ginseng. Ginsenoside blocks binding of IGF-1 to its receptor with an IC₅₀ of ~90 nM. Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

IC₅₀ Target^[1]^[2]

p65

;

COX-2

;

IGF-1R

90 nM (IC₅₀)

体外研究
(In Vitro)

Ginsenoside Rg5 plays a novel role as an IGF-1R agonist. Ginsenoside Rg5 binds to IGF-1R with an IC₅₀ value of ~90 and its angiogenic activity is inhibited by IGF-1R knockdown. To investigate the possible interaction of Ginsenoside Rg5 with IGF-1R, a docking analysis is performed. Docking results show that Ginsenoside Rg5 binds strongly at two sites, A and B, with K_d values of 20 and 27 nM, respectively, to the cysteine-rich domain of IGF-1R. Pretreatment with Rg5 blocks the binding of radiolabeled IGF-1 to HUVECs with an IC₅₀ value of ~90 μM, which is greater than an IC₅₀ value of ~1.4 nM for unlabeled IGF-1^[1]. The results from MTT assay show that MCF-7 cell proliferation is inhibited by Ginsenoside Rg5 treatment for 24, 48 and 72 h in a dose-dependent manner. Ginsenoside Rg5 at different concentrations (0, 25, 50 and 100 μM), induce cell cycle arrest in G0/G1 phase through regulation of cell cycle-related proteins in MCF-7 cells^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Ginsenoside Rg5 inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65 in lipopolysaccharides (LPS)-stimulated BV2 microglial cells. Rg5 pretreated group mice show declined expression of NF-κB p65 and COX-2. In the group treated with low dose of Ginsenoside Rg5 (10 mg/kg), there is remarkable tubular damage and infiltration of inflammatory cells. However, at the higher dose of Ginsenoside Rg5 (20 mg/kg), tubules markedly appeare histologically normal and no inflammation and cast formation is observed in kidney tissues^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

767.00

Formula

C₄₂H₇₀O₁₂

CAS 号

186763-78-0

中文名称

人参皂甙 Rg5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20deg;C	3 years
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : 100 mg/mL (130.38 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.3038 mL	6.5189 mL	13.0378 mL
5 mM	0.2608 mL	1.3038 mL	2.6076 mL
10 mM	0.1304 mL	0.6519 mL	1.3038 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (3.26 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.26 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.26 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.26 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.26 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.26 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Cho YL, et al. Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5 promotes angiogenesis and vasorelaxation. J Biol Chem. 2015 Jan 2;290(1):467-77.

[2]. Li W, et al. Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis. Nutrients. 2016 Sep 13;8(9). pii: E566.

[3]. Kim SJ, et al. Anti-breast cancer activity of Fine Black ginseng (Panax ginseng Meyer) and ginsenoside Rg5. J Ginseng Res. 2015 Apr;39(2):125-34.

Kinase Assay ^[1]	HUVECs are cultured in 24-well plates overnight. The cells are changed to serum-free M199 and incubated for 1 h. The medium is removed, and cells are incubated with fresh serum-free medium containing 0.1 μM-50 mM Ginsenoside Rg5 at 37°C for 20 min followed by the addition of 50 μL (1 μCi) of [¹²⁵I]IGF-1 and then further incubated for 10 min. The medium is decanted, and cell plates are washed twice with serum-free medium. Cells are lysed in 300 μL of 0.1 N NaOH solution containing 0.1% SDS, transferred to scintillation vials, and mixed with 1 mL of Ultima Gold mixture solution. Cell-associated [¹²⁵I]IGF-1 is analyzed in a scintillation counter. The nonspecific binding is determined by coincubation with unlabeled IGF-1 (50 nM)^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Assay ^[3]	MCF-7 (HER2^–/ER⁺) and MDA-MB-453 (HER2⁺/ER^–) human breast cancer cell lines are maintained using RPMI 1640 medium supplemented with 10% (vol/vol) FBS plus 100 units/mL Penicillin and Streptomycin in a 5% carbon dioxide air incubator at 37°C. Cell cytotoxicity is measured by MTT assay. Cells are seeded in 96-well tissue culture plates at the density of 0.2×10⁴ cells per well with 100 μL medium, and are allowed to become attached for 24 h. One hundred microliters of the medium with different concentrations of Ginsenoside Rg5 (e.g., 0 μM, 25 μM, 50 μM, and 100 μM) are added to each well. At indicated times, 30 μL MTT stock solution (3 mg/mL) are added to each well. After culturing the cells at 37°C for 2 h, DMSO is added to dissolve the formazan crystals. The absorbance is read at the wavelength of 540 nm with a microplate reader^[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[2]	Mice^[2] Male ICR mice (6 to 8 weeks old), weighing 25-27 g, are used. After acclimation for one week, mice are randomly assigned into 4 experimental groups with 8 mice in each group: normal control, Cisplatin control, and Cisplatin+Ginsenoside Rg5 groups (10 and 20 mg/kg, respectively). Ginsenoside Rg5 is administered intragastrically at the dose of 10 and 20 mg/kg for 10 days. On the 7th day, animals in Cisplatin control and Ginsenoside Rg5-treated groups receive a single intraperitoneal injection of Cisplatin (25 mg/kg) to induce nephrotoxicity in mice. Mice are anaesthetized with pentobarbital, subsequently sacrificed at 72 h after Cisplatin injection (Day 10). Blood samples are collected and then centrifuged at 3000 rpm to separate the serum and stored at -20 °C for determining blood urea nitrogen (BUN) and creatinine (CRE) levels. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Cho YL, et al. Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5 promotes angiogenesis and vasorelaxation. J Biol Chem. 2015 Jan 2;290(1):467-77. [2]. Li W, et al. Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis. Nutrients. 2016 Sep 13;8(9). pii: E566. [3]. Kim SJ, et al. Anti-breast cancer activity of Fine Black ginseng (Panax ginseng Meyer) and ginsenoside Rg5. J Ginseng Res. 2015 Apr;39(2):125-34.

Ginsenoside Rg2(Synonyms: 人参皂苷 Rg2; Chikusetsusaponin I; Panaxoside Rg2; Prosapogenin C2)

发表于2024年4月10日由Whatman官网

天然产物糖类和糖苷 Saccharides and Glycosides

Ginsenoside Rg2;(Synonyms: 人参皂苷 Rg2; Chikusetsusaponin I; Panaxoside Rg2; Prosapogenin C2) 纯度: ge;98.0%

Ginsenoside Rg2 是人参的主要活性成分之一。Ginsenoside Rg2抑制脂多糖介导的 VCAM-1 和 ICAM-1 表达的增加。 Ginsenoside Rg2 还降低 Aβ_1-42 积聚。

Ginsenoside Rg2 Chemical Structure

CAS No. : 52286-74-5

规格	价格	是否有货	数量
10;mM;*;1 mL in DMSO	￥1036	In-stock
5 mg	￥700	In-stock
10 mg	￥1200	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

Ginsenoside Rg2 相关产品

bull;相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Immunology/Inflammation Compound Library
Neuronal Signaling Compound Library
NF-kappa;B Signaling Compound Library
Stem Cell Signaling Compound Library
Natural Product Library
Anti-Cancer Compound Library
Anti-Aging Compound Library
Antioxidants Compound Library
Differentiation Inducing Compound Library
Glycoside Compound Library
Lipid Compound Library
Oxygen Sensing Compound Library
Anti-Cardiovascular Disease Compound Library
Medicine Food Homology Compound Library
Terpenoids Library
Pyroptosis Compound Library
Traditional Chinese Medicine Monomer Library
Anti-Alzheimer’s Disease Compound Library
Anti-Breast Cancer Compound Library
Anti-Pancreatic Cancer Compound Library
Anti-Blood Cancer Compound Library
Neurodegenerative Disease-related Compound Library
Anti-Obesity Compound Library
Transcription Factor Targeted Library
Food-Sourced Compound Library
Anti-Liver Cancer Compound Library

生物活性

Ginsenoside Rg2 is one of the major active components of ginseng. Ginsenoside Rg2 inhibits VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS). Ginsenoside Rg2 also reduces Aβ_1-42 accumulation.

IC₅₀ Target^[1]^[2]

NF-κB

;

Aβ_1-42

;

体外研究
(In Vitro)

Ginsenoside Rg2 prevents the decrease of IκB expression stimulated with lipopolysaccharide (LPS). IκB dissociation from RelA-p50 complex is crucial for NF-κB activity. Ginsenoside Rg2, protopanaxatriol, inhibits vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) expression stimulated with LPS from human umbilical vein endothelial cell (HUVEC). The inhibition of VCAM-1 and ICAM-1 expression by Ginsenoside Rg2 is in a concentration-dependent manner, significantly. Treatment of endothelial cells with LPS (1µg/mL) decreases IκBα expression. By 1 hr after LPS treatment, significant decrease of IκBα is attained. To determine whether LPS-stimulated IκBα expression is affected by Ginsenoside Rg2, endothelial cells are treated for 1 hr with Ginsenoside Rg2 (1~50 µM) prior to LPS (1 µg/mL) stimulation for 1 hr. Ginsenoside Rg2 reverses the decrease of LPS-induced IκBα expression in a concentration-dependent manner, significantly. The adhesion of THP-1 cells to endothelial cells is measured using quantitative monolayer adhesion assay. The adhesion of THP-1 cells onto endothelial cells are increased to five folds by LPS (1 µg/mL) stimulation for 8 hrs. Ginsenoside Rg2 (1~50 µM) inhibits the adhesion of THP-1 cells to endothelial cells stimulated with LPS, in a concentration-dependent manner^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

G-Rg1 and Ginsenoside Rg2 (G-Rg2) reduce the escape latencies on the last two training days compared to the Alzheimer’s disease (AD) model group (p<0.05). In the spatial exploration test, the total time spent in the target quadrant and the number of mice that exactly crossed the previous position of the platform are clearly shorter and lower, respectively, in the AD model group mice than in the normal control group mice (p<0.01), a trend that is reversed by treatment with G-Rg1 and Ginsenoside Rg2 (G-Rg1, p<0.01; Ginsenoside Rg2, p<0.05). Treatment with G-Rg1 and Ginsenoside Rg2 effectively improve cognitive function of the mice that have declined due to AD. G-Rg1 and Ginsenoside Rg2 reduce Aβ_1-42 accumulation in APP/PS1 mice. In the G-Rg1 and Ginsenoside Rg2 treated mice, the pathological abnormalities observed in the APP/PS1 mice are gradually ameliorated. Clear nucleoli and light brown, sparsely scattered Aβ deposits are visible^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

785.01

Formula

C₄₂H₇₂O₁₃

CAS 号

52286-74-5

中文名称

人参皂苷 Rg2；人参皂苷 Rg2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20deg;C	3 years
	4deg;C	2 years
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : 100 mg/mL (127.39 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.2739 mL	6.3693 mL	12.7387 mL
5 mM	0.2548 mL	1.2739 mL	2.5477 mL
10 mM	0.1274 mL	0.6369 mL	1.2739 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (3.18 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.18 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.18 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.18 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.18 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.18 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Cho YS, et al. Ginsenoside rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell. Korean J Physiol Pharmacol. 2013 Apr;17(2):133-7.

[2]. Li N, et al. A UPLC/MS-based metabolomics investigation of the protective effect of ginsenosides Rg1 and Rg2 in mice with Alzheimer’s disease. J Ginseng Res. 2016 Jan;40(1):9-17.

[3]. Cho YS, et al. Ginsenoside rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell. Korean J Physiol Pharmacol. 2013;17(2):133-137.

Cell Assay	HUVECs ares grown in EBM-2 containing 10% FBS at a density of 2.0×10⁵ cells/well on 24-well plates. Endothelial cells at 90~95% confluence are treated with Ginsenoside Rg2 (1, 20, 50 µM) for 1 hr prior to 1 µg/mL of LPS stimulation for 8 hr. THP-1 cells are labeled with Calcein-AM (5 µM) in RPMI 1640 medium containing 10% FBS for 30 min. After extensive washing with PBS, the labeled THP-1 cells are seeded at a density of 5.0×10⁵ cells/well onto endothelial cells which are treated with the Rg2 and/or LPS and, then, incubated for 1 hr at 37°C while gentle shaking. After incubation, non-adherent cells are removed by gentle washing two times with PBS. Photograph images are obtained at 485 nm excitation and 538 nm emission using a SPOT II digital camera-attached fluorescence microscope^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[2]	Mice^[2] Male APP/PS1 mice, weighing 20±2 g, and male C57BL/6J mice, weighing 20±2 g, are used. The animals are maintained in an air-conditioned animal center at 23±2°C and a relative humidity of 50±10%, with a natural light-dark cycle. Food and water are available ad libitum. After acclimatization for 1 wk, the mice are divided into four groups (n=10 in each group): the normal control group, the AD model group, the G-Rg1 group, and the Ginsenoside Rg2 group. According to the concentration-response curves, the mice in the G-Rg1 and Ginsenoside Rg2 groups are injected intraperitoneally once daily with G-Rg1 and Ginsenoside Rg2 (30 mg/kg), respectively, dissolved in saline. The mice in the AD model group (APP/PS1 mice) and the normal control group (C57BL/6J nontransgenic littermates) are treated with isodose saline (0.9% w/v). All mice are treated for 1 mo before brain metabolite profiling. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Cho YS, et al. Ginsenoside rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell. Korean J Physiol Pharmacol. 2013 Apr;17(2):133-7. [2]. Li N, et al. A UPLC/MS-based metabolomics investigation of the protective effect of ginsenosides Rg1 and Rg2 in mice with Alzheimer’s disease. J Ginseng Res. 2016 Jan;40(1):9-17. [3]. Cho YS, et al. Ginsenoside rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell. Korean J Physiol Pharmacol. 2013;17(2):133-137.

RG7422 品牌：SynKinase

发表于2024年2月8日由Whatman官网

RG7422

品牌：SynKinase
CAS No.：1032754-93-0
储存条件：-20°C
纯度：>95%

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
SYN-1150-M001	–	1 mg	–	1,510.00	–	–

* 干冰运输、大包装及大批量的产品需酌情添加运输费用

Cytiva思拓凡-Whatman滤纸滤膜滤器

沃特曼官网代理商|Whatman滤纸滤膜中国官网代理商

标签归档：rg

Ginsenoside Rg3 人参皂甙Rg3 品牌：Chemodex

Ginsenoside Rg3

人参皂甙Rg3

Ginsenoside Rg3 人参皂甙Rg3 品牌：Chemodex

Ginsenoside Rg3

人参皂甙Rg3

20(S)-Ginsenoside Rg3(Synonyms: 20(S)-人参皂苷 Rg3; 20(S)-Propanaxadiol; S-ginsenoside Rg3)

20(S)-Ginsenoside Rg3 相关产品

bull;相关化合物库:

Ginsenoside Rg1(Synonyms: 人参皂苷 Rg1; Panaxoside A; Panaxoside Rg1)

Ginsenoside Rg1 相关产品

bull;相关化合物库:

(20R)-Ginsenoside Rg3(Synonyms: (20R)-人参皂苷Rg3; (20R)-Propanaxadiol; R-ginsenoside Rg3)

(20R)-Ginsenoside Rg3 相关产品

bull;相关化合物库:

Ginsenoside Rg6(Synonyms: 人参皂苷 Rg6)

Ginsenoside Rg6 相关产品

bull;相关化合物库:

I-bu-rG Phosphoramidite

I-bu-rG Phosphoramidite 相关产品

bull;相关化合物库:

Ginsenoside Rg5(Synonyms: 人参皂甙 Rg5)

Ginsenoside Rg5 相关产品

bull;相关化合物库:

Ginsenoside Rg2(Synonyms: 人参皂苷 Rg2; Chikusetsusaponin I; Panaxoside Rg2; Prosapogenin C2)

Ginsenoside Rg2 相关产品

bull;相关化合物库:

RG7422 品牌：SynKinase

RG7422