标签归档：quinone

Pyrroloquinoline quinone(Synonyms: 吡咯喹啉醌; PQQ; Methoxatin)

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天然产物醌类Quinones

Pyrroloquinoline quinone (Synonyms: 吡咯喹啉醌; PQQ; Methoxatin) 纯度: 99.53%

Pyrroloquinoline quinone (PQQ) 是氧化还原辅助因子，一种阴离子型氧化还原循环原醌。Pyrroloquinoline quinone 最初是从嗜甲基细菌的培养物中分离的，也存在于哺乳动物的组织。Pyrroloquinoline quinone 是哺乳动物的必需营养素，对免疫功能很重要。

Pyrroloquinoline quinone(Synonyms: 吡咯喹啉醌; PQQ; Methoxatin)

Pyrroloquinoline quinone Chemical Structure

CAS No. : 72909-34-3

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Pyrroloquinoline quinone 相关产品

•相关化合物库:

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  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Human Endogenous Metabolite Compound Library
  • Microbial Metabolite Library
  • Food-Sourced Compound Library

生物活性

Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Mouse pups born to and nursing from Pyrroloquinoline quinone (PQQ)-deprived dams have a compromised immune response as well as alopecia, a hunched posture, and a susceptibility to aortic aneurysms[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

330.21

Formula

C14H6N2O8
CAS 号

72909-34-3
中文名称

吡咯喹啉醌；吡咯并喹啉苯醌
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : 1 mg/mL (3.03 mM; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0284 mL 15.1419 mL 30.2838 mL
5 mM — — —
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Moog RS, et al. Evidence for methoxatin (pyrroloquinolinequinone) as the cofactor in bovine plasma amine oxidase from resonance Raman spectroscopy. Proc Natl Acad Sci U S A. 1986 Nov;83(22):8435-9.

    [2]. Bishop A, et al. Methoxatin (PQQ) in guinea-pig neutrophils. Free Radic Biol Med. 1994 Oct;17(4):311-20.