PSI (Proteasome Inhibitor 1) is a potent proteasome inhibitor. PSI inhibits the proliferation of primary effusion lymphoma (PEL) cells. PSI has the potential for the research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-associated lymphomas[1].
体外研究 (In Vitro)
PSI (24 h) inhibits the proliferation of primary effusion lymphoma (PEL) cells at low nanomolar concentrations (CC50s of 205, 190, 22.0, 53.0 nM FOR BJAB, Ramos, BC3, BCBL1 cells, respectively)[1]. PSI (50 nM; 6 h) increases caspase-3/7 activity by 8-fold compared with control[1]. PSI (50 nM; 6 h) decreases the transcriptional activity of NF-κB by 52%[1]. PSI (1, 5 nM; 3 days) inhibits the growth of BC3 cells at a high concentration (5 nM)[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Cytotoxicity Assay[1]
Cell Line:
BC3, BCBL1, Ramos, BJAB cells
Concentration:
Incubation Time:
24 h
Result:
Inhibited the proliferation of primary effusion lymphoma (PEL) cells at low nanomolar concentrations (CC50s of 205, 190, 22.0, 53.0 nM FOR BJAB, Ramos, BC3, BCBL1 cells, respectively).
Western Blot Analysis[1]
Cell Line:
HBL6 cells
Concentration:
50 nM
Incubation Time:
6 h
Result:
Decreased the NF-κB activity by 52%.
分子量
618.76
Formula
C32H50N4O8
CAS 号
158442-41-2
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Saji C, et al. Proteasome inhibitors induce apoptosis and reduce viral replication in primary effusion lymphoma cells. Biochem Biophys Res Commun. 2011; 415(4):573-8.
Proteasome-activating peptide 1 Chemical Structure
CAS No. : 1565763-62-3
规格
是否有货
100 mg
;
询价
;
250 mg
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询价
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500 mg
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生物活性
Proteasome-activating peptide 1 is a peptide, which increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. Proteasome-activating peptide 1 prevents protein aggregation in a cellular model of amyotrophic lateral sclerosis[1].
分子量
1517.99
Formula
C63H116N22O13S4
CAS 号
1565763-62-3
Sequence Shortening
IPRCRKMPGVKMC-NH2
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Dal Vechio FH, et al. Peptides that activate the 20S proteasome by gate opening increased oxidized protein removal and reduced protein aggregation. Free Radic Biol Med. 2014;67:304-313.
Proteasome-activating peptide 1 TFA Chemical Structure
规格
价格
是否有货
数量
1 mg
¥1300
In-stock
5 mg
¥2900
In-stock
10 mg
¥4700
In-stock
50 mg
;
询价
;
100 mg
;
询价
;
* Please select Quantity before adding items.
Proteasome-activating peptide 1 TFA 相关产品
bull;相关化合物库:
Bioactive Compound Library Plus
Peptide Library
生物活性
Proteasome-activating peptide 1 TFA is a peptide, which increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. Proteasome-activating peptide 1 TFA prevents protein aggregation in a cellular model of amyotrophic lateral sclerosis[1].
分子量
1632.02
Formula
C65H117F3N22O15S4
Sequence Shortening
IPRCRKMPGVKMC-NH2
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Dal Vechio FH, et al. Peptides that activate the 20S proteasome by gate opening increased oxidized protein removal and reduced protein aggregation. Free Radic Biol Med. 2014;67:304-313.