Protease-Activated Receptor-1, PAR-1 Agonist;
Protease-Activated Receptor-1, PAR-1 Agonist 是一种选择性蛋白酶激活受体1 (PAR-1) 激动肽。Protease-Activated Receptor-1, PAR-1 Agonist 对应于PAR1配体,可通过该受体选择性地模拟凝血酶的作用。
Protease-Activated Receptor-1, PAR-1 Agonist Chemical Structure
CAS No. : 141136-85-8
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100 mg |
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250 mg |
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500 mg |
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Protease-Activated Receptor-1, PAR-1 Agonist 的其他形式现货产品:
Protease-Activated Receptor-1, PAR-1 Agonist TFA
生物活性 |
Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor[1][2].
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体外研究 (In Vitro) |
Protease-Activated Receptor-1, PAR-1 Agonist induces activation of protein kinase C isoenzymes alpha and epsilon in human HT-29 colon carcinoma cells expressing PAR1 endogeneously. On the cellular level, Protease-Activated Receptor-1, PAR-1 Agonist and thrombin prompted HT-29 cell migration and matrix adhesion by a PKCepsilon-dependent mechanism as concluded because of the inhibition of PAR1-mediated effects by the PKC inhibitor bisindolylmaleimide I and the PKCepsilon translocation inhibitory peptide EAVSLKPT but not by the PKC inhibitor Gö 6976[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Sequence Shortening |
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Room temperature in continental US; may vary elsewhere.
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis.
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参考文献 |
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[1]. Stefanie Gödecke, et al. Thrombin-induced ATP release from human umbilical vein endothelial cells. Am J Physiol Cell Physiol. 2012 Mar 15;302(6):C915-23.
[2]. Heider I, et al. PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism. Oncol Res. 2004;14(10):475-482.
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