PMQA (Zn-green), an 8-aminoquinoline-based ratiometric fluorescent sensor, demonstrates the Zn²⁺-induced redshift of emission (85 nm). PMQA (Zn-green) is a cell membrane-permeable probe and suitable for imaging Zn²⁺ in living cells^[1].

After incubation with PMQA (20 μM) for 1 h, weak green fluorescence appeared, presumably caused by the probe capturing intracellular zinc from its native ligands since PMQA has high affinity for zinc^[1].
The response of PMQA to Zn²⁺ can be reversed by N,N,N’,N’-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) or EDTA^[1].
When the stock solution of PMQA (0.1 mM in Tris Buffer) is kept at room temperature for a week, there is no significant loss of PMQA determined by HPLC analysis^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

292.34

C₁₇H₁₆N₄O

1263820-18-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liangwei Zhang, et al. 8-Aminoquinoline-based ratiometric zinc probe: unexpected binding mode and its application in living cells. Bioorg Med Chem Lett. 2013 Jun 15;23(12):3511-4.