标签归档：plp

[SER140]-PLP(139-151) TFA

发表于由

[SER140]-PLP(139-151) TFA; 纯度: 99.03%

[SER140]-PLP(139-151) (TFA) 是髓鞘蛋白脂质蛋白的多肽片段。

[SER140]-PLP(139-151) TFAamp;;

[SER140]-PLP(139-151) TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥1100 In-stock
5 mg ￥4900 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

[SER140]-PLP(139-151) TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

[SER140]-PLP(139-151) (TFA) is a fragment of myelin proteolipid protein[1].

分子量

1635.74

Formula

C74H105F3N20O19
Sequence Shortening

HSLGKWLGHPDKF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (61.13 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6113 mL 3.0567 mL 6.1134 mL
5 mM 0.1223 mL 0.6113 mL 1.2227 mL
10 mM 0.0611 mL 0.3057 mL 0.6113 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Kordopati GG, et al. Biologically relevant conformational features of linear and cyclic proteolipid protein (PLP) peptide analogues obtained by high-resolution nuclear magnetic resonance and molecular dynamics. J Comput Aided Mol Des. 2017 Jul 29.

PLP (139-151)

发表于由

PLP (139-151); 纯度: 98.34%

PLP (139-151) 是髓鞘蛋白脂蛋白 (PLP) 139至151氨基酸片段。用于诱导实验性自身免疫性脑脊髓炎 (EAE)。

PLP (139-151)amp;;

PLP (139-151) Chemical Structure

CAS No. : 131334-43-5

规格 价格 是否有货 数量
1 mg ￥990 In-stock
5 mg ￥3900 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

PLP (139-151) 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Animal Disease Model Inducer Library
  • Peptide Library

生物活性

PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE).

体外研究
(In Vitro)

Severe clinical and histological EAE could be induced by adoptive transfer of the peptide-specific T cell line and 3 of 4 T cell clones. The T cell line/clones all responded strongly to PLP (139-151) in in vitro proliferative assays. Line SPL and all of the clones show strong proliferative response to the whole PLP molecule and to PLP (139-151)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

PLP (139-151) induces acute experimental allergic encephalomyelitis (EAE) in SJL/J mice. Beginning on Day 9, the mice treated with PLP (139-151) show signs of EAE and the disease progressed rapidly to paralysis. Central nervous system inflammation, edema, gliosis, and demyelination are found in all mice killed between Days 10 and 28[2]. Young male SJL mice immunized with a major encephalitogenic peptide of myelin, PLP 139-151, develop initial clinical and histological symptoms of EAE with a severity similar to age-matched females; however, unlike females, male mice does not relapse. Significant T cell proliferation to PLP 139-151, but not to other PLP and myelin basic protein (MBP) epitopes, is observed in both males and females during the initial episode, recovery, and first relapse of clinical disease[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1537.79

Formula

C72H104N20O16S
CAS 号

131334-43-5
Sequence

His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe
Sequence Shortening

HCLGKWLGHPDKF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : ≥ 50 mg/mL (32.51 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6503 mL 3.2514 mL 6.5028 mL
5 mM 0.1301 mL 0.6503 mL 1.3006 mL
10 mM 0.0650 mL 0.3251 mL 0.6503 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Kuchroo VK, et al. Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology. 1991;59(5):305-12.

    [2]. Sobel RA, et al. Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide ofmyelin proteolipid protein. J Neuropathol Exp Neurol. 1990 Sep;49(5):468-79.

    [3]. Bebo BF Jr, et al. Male SJL mice do not relapse after induction of EAE with PLP 139-151. J Neurosci Res. 1996 Sep 15;45(6):680-9.

Parathyroid Hormone-like Peptide (PLP) (Human, 140-173) 品牌：Anygen

发表于由

Parathyroid Hormone-like Peptide (PLP) (Human, 140-173)

品牌：Anygen
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

304-91201

 – 0.5 mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

[SER140]-PLP(139-151)

发表于由

[SER140]-PLP(139-151);

[SER140]-PLP(139-151) 是髓鞘蛋白脂质蛋白的多肽片段。

[SER140]-PLP(139-151)amp;;

[SER140]-PLP(139-151) Chemical Structure

CAS No. : 122018-58-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

[SER140]-PLP(139-151) 的其他形式现货产品:

[SER140]-PLP(139-151) TFA

生物活性

[SER140]-PLP(139-151) is a fragment of myelin proteolipid protein.

分子量

1521.72

Formula

C72H104N20O17
CAS 号

122018-58-0
Sequence Shortening

HSLGKWLGHPDKF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Kordopati GG, et al. Biologically relevant conformational features of linear and cyclic proteolipid protein (PLP) peptide analogues obtained by high-resolution nuclear magnetic resonance and molecular dynamics. J Comput Aided Mol Des. 2017 Jul 29.