天然产物 糖类和糖苷 Saccharides and Glycosides
Paromomycin sulfate;(Synonyms: 硫酸巴龙霉素; Aminosidine sulfate) 纯度: ge;98.0%
Paromomycin (Aminosidine) sulfate 是一种的广谱氨基糖苷类抗生素 (antibiotic)，具有杀螨杀菌作用，是新霉素 (HY-B0470) 衍生物。Paromomycin sulfate 通过与细菌 30S 核糖体 A 位点的 RNA 寡核苷酸特异性结合，使 mRNA 的翻译提前终止，并抑制蛋白质合成。Paromomycin sulfate 可用于细菌和寄生虫感染的研究。
Paromomycin sulfate Chemical Structure
CAS No. : 1263-89-4
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| Free Sample (0.1-0.5 mg) | ; | Apply now | ; |
| 10;mM;*;1 mL in Water | ￥500 | In-stock | |
| 500 mg | ￥400 | In-stock | |
| 1 g | ￥500 | In-stock | |
| 5 g | ; | 询价 | ; |
| 10 g | ; | 询价 | ; |
* Please select Quantity before adding items.
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| 生物活性 |
Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections[1][2][3]. |
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| 体外研究 (In Vitro) |
Paromomycin sulfate (500 μg/ml) reduces intracellular parasitic forms by 97.2% compared to control in Caco-2 cells and reduces the percentage of intracellular C. parvum forms by 99.5% in HCT-8 cells[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 体内研究 (In Vivo) |
Paromomycin sulfate (oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infection) reduces the number of oocyst per gram of feces and intestine. It shows minimal focal inflammation in only 20% of the sections at 50 mg/kg from the intestines of mice infected with C. parvum and only 10% of focal inflammation at 200 mg/kg[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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| Clinical Trial |
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| 分子量 |
713.71 |
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| Formula |
C23H47N5O18S |
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| CAS 号 |
1263-89-4 |
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| 中文名称 |
硫酸巴龙霉素 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
4deg;C, sealed storage, away from moisture *In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture) |
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| 溶解性数据 |
In Vitro:;
H2O : 100 mg/mL (140.11 mM; ultrasonic and warming and heat to 80°C) Ethanol : 1 mg/mL (1.40 mM; Need ultrasonic) DMSO : 1 mg/mL (1.40 mM; ultrasonic and warming and heat to 80°C) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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| 参考文献 |
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