Parathyroid Hormone 品牌：Anygen

发表于2024年11月2日由Whatman官网

Parathyroid Hormone

品牌：Anygen
CAS No.：
储存条件：-20℃
纯度：–

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
307-18433	–	0.5 mg	–	咨询	–	–

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Parathyroid Hormone (1-34), human, biotinylated

发表于2024年9月12日由Whatman官网

Parathyroid Hormone (1-34), human, biotinylated;

Parathyroid Hormone (1-34), human, biotinylated 是甲状旁腺激素受体的探针，可用于分析活细胞中甲状旁腺激素和甲状旁腺激素受体之间的相互作用，并通过亲和柱纯化激素-受体复合物。

Parathyroid Hormone (1-34), human, biotinylated Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

Parathyroid Hormone (1-34), human, biotinylated is a probe for the parathyroid hormone receptor, can be used for analyzing the interaction between parathyroid hormone and parathyroid hormone receptors in living cells and for purifying hormone-receptor complexes with affinity columns^[1]^[2].

分子量

4344.10

Formula

C₁₉₁H₃₀₅N₅₇O₅₃S₃

Sequence

Biotin-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe

Sequence Shortening

Biotin-SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Newman W, et, al. Biotinylated parathyroid hormone as a probe for the parathyroid hormone receptor. Structure-function analysis and detection of specific binding to cultured bone cells by flow cytometry. J Biol Chem. 1989 Oct 5; 264(28): 16359-65.

[2]. Banerjee S, et, al. Synthesis and characterization of novel biotinylated carboxyl-terminal parathyroid hormone peptides that specifically crosslink to the CPTH-receptor. Peptides. 2006 Dec; 27(12): 3352-62.

Parathyroid Hormone (PTH)(44-68)(Human) 品牌：Anygen

发表于2024年9月10日由Whatman官网

Parathyroid Hormone (PTH)(44-68)(Human)

品牌：Anygen
CAS No.：
储存条件：-20℃
纯度：–

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
303-91151	–	0.5 mg	–	咨询	–	–

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Parathyroid Hormone (Human, 1-34) 品牌：Peptide

发表于2024年9月8日由Whatman官网

Parathyroid Hormone (Human, 1-34)

品牌：Peptide
CAS No.：
储存条件：-20℃
纯度：–

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
337-40683	–	0.5mg	–	咨询	–	–

* 干冰运输、大包装及大批量的产品需酌情添加运输费用

Parathyroid Hormone (1-34), bovine

发表于2024年7月15日由Whatman官网

Parathyroid Hormone (1-34), bovine;

Parathyroid Hormone (1-34), bovine 是一种有效的甲状旁腺激素 (PTH) 受体激动剂。Parathyroid Hormone (1-34), bovine 增加钙和无机磷酸盐的水平。Parathyroid Hormone (1-34), bovine 可用于研究骨质疏松症。

Parathyroid Hormone (1-34), bovine Chemical Structure

CAS No. : 12583-68-5

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

Parathyroid Hormone (1-34), bovine is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis^[1].

体外研究
(In Vitro)

Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) are added to the medium, it inhibits osteoblast proliferation in a dose-dependent manner. In another group, bPTH are added to the culture medium from day 1 to day 10, but not from days 11 to 20, a rebound of proliferation is observed in the PTH Day 1–10 group after bPTH withdrawal^[1].
Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) induces diverse effects on the calcium and phosphorus content of culture medium. The calcium and phosphorus content of culture medium in the PTH-C 100 ng/mL group are higher than in teh control group^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	MC3T3-E1 cells
Concentration:	0.1-100 ng/mL
Incubation Time:	2-20 days
Result:	Resulted a decrease of osteoblast proliferationin concentration-dependent manner. Resulted in a rebound of proliferation when PTH withdrawal.

体内研究
(In Vivo)

Parathyroid Hormone (1-34)(subcutaneous injection; 80 μg/kg; 5 days) increases serum osteocalcin concentrations without changing serum inorganic phosphate or calcium concentrations in either group of old animals. Serum 1,25-dihydroxyvitamin D concentrations are significantly higher in the PTH-treated senile female rats than the sex-matchedvehicle-treated controls^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

4108.77

Formula

C₁₈₃H₂₈₈N₅₄O₅₀S₂

CAS 号

12583-68-5

Sequence Shortening

AVSEIQFMHNGKHLSSMERVEWLRKKLQDVHNF

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. B H Mitlak, et al. Intermittent administration of bovine PTH-(1-34) increases serum 1,25-dihydroxyvitamin D concentrations and spinal bone density in senile (23 month) rats. J Bone Miner Res. 1992 May;7(5):479-84.

[2]. M Takigawa, et al. Studies on chondrocytes from mandibular condylar cartilage, nasal septal cartilage, and spheno-occipital synchondrosis in culture. I. Morphology, growth, glycosaminoglycan synthesis, and responsiveness to bovine parathyroid hormone (1-34). J Dent Res. 1984 Jan;63(1):19-22.

Parathyroid Hormone (1-34), bovine TFA

发表于2024年7月6日由Whatman官网

Parathyroid Hormone (1-34), bovine TFA;

Parathyroid Hormone (1-34), bovine TFA 是一种有效的甲状旁腺激素 (PTH) 受体激动剂。Parathyroid Hormone (1-34), bovine 增加钙和无机磷酸盐的水平。Parathyroid Hormone (1-34), bovine 可用于研究骨质疏松症。

Parathyroid Hormone (1-34), bovine TFA Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性	Parathyroid Hormone (1-34), bovine TFA is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis^[1].
体外研究 (In Vitro)	Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) are added to the medium, it inhibits osteoblast proliferation in a dose-dependent manner. In another group, bPTH are added to the culture medium from day 1 to day 10, but not from days 11 to 20, a rebound of proliferation is observed in the PTH Day 1–10 group after bPTH withdrawal^[1]. Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) induces diverse effects on the calcium and phosphorus content of culture medium. The calcium and phosphorus content of culture medium in the PTH-C 100 ng/mL group are higher than in the control group^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)	Parathyroid Hormone (1-34)(subcutaneous injection; 80 μg/kg; 5 days) increases serum osteocalcin concentrations without changing serum inorganic phosphate or calcium concentrations in either group of old animals. Serum 1,25-dihydroxyvitamin D concentrations are significantly higher in the PTH-treated senile female rats than the sex-matchedvehicle-treated controls^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	4222.79
Formula	C₁₈₅H₂₈₉F₃N₅₄O₅₂S₂
Sequence Shortening	AVSEIQFMHNGKHLSSMERVEWLRKKLQDVHNF
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. B H Mitlak, et al. Intermittent administration of bovine PTH-(1-34) increases serum 1,25-dihydroxyvitamin D concentrations and spinal bone density in senile (23 month) rats. J Bone Miner Res. 1992 May;7(5):479-84. [2]. M Takigawa, et al. Studies on chondrocytes from mandibular condylar cartilage, nasal septal cartilage, and spheno-occipital synchondrosis in culture. I. Morphology, growth, glycosaminoglycan synthesis, and responsiveness to bovine parathyroid hormone (1-34). J Dent Res. 1984 Jan;63(1):19-22.

Parathyroid hormone (1-34) (rat)

发表于2024年5月3日由Whatman官网

Parathyroid hormone (1-34) (rat); 纯度: 95.53%

Parathyroid hormone (1-34) (rat) 是甲状旁腺激素，可改善皮质和松质骨结构。

Parathyroid hormone (1-34) (rat) Chemical Structure

CAS No. : 98614-76-7

规格	价格	是否有货	数量
1 mg	￥3200	In-stock
5 mg	￥9000	In-stock
10 mg	;	询价	;
50 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

Parathyroid hormone (1-34) (rat) improves both cortical and cancellous bone structure^[1].

体内研究
(In Vivo)

PTH (80 μg/kg per day (hPTH), s.c., 4 weeks ) induces a ~35% recovery of this loss and a ~40% reversal of the associated decreases in trabecular number (Tb.N) and connectivity. PTH also causes a shift from single to double calcein-labeled trabecular surfaces, a significant enhancement in the mineralizing perimeter and a respective 2- and 3-fold stimulation of the mineral appositional rate (MAR) and bone formation rate (BFR)^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sixty-three 11-week-old virgin female Swiss-Webster mice^[2].
Dosage:	80 μg/kg per day (hPTH).
Administration:	S.C., 4 weeks (5 days a week).
Result:	OVX osteoporotic mice respond to PTH by increased osteoblast activity and the consequent restoration of trabecular network.

分子量

4057.71

Formula

C₁₈₀H₂₉₁N₅₅O₄₈S₂

CAS 号

98614-76-7

Sequence Shortening

AVSEIQLMHNLGKHLASVERMQWLRKKLQDVHNF

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80deg;C	2 years
	-20deg;C	1 year
In solvent	-80deg;C	6 months
	-20deg;C	1 month

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

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标签归档：parathyroid

Parathyroid Hormone 品牌：Anygen

Parathyroid Hormone

Parathyroid Hormone (1-34), human, biotinylated

Parathyroid Hormone (PTH)(44-68)(Human) 品牌：Anygen

Parathyroid Hormone (PTH)(44-68)(Human)

Parathyroid Hormone (Human, 1-34) 品牌：Peptide

Parathyroid Hormone (Human, 1-34)

Parathyroid Hormone (1-34), bovine

Parathyroid Hormone (1-34), bovine TFA

Parathyroid hormone (1-34) (rat)

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Parathyroid Hormone

Parathyroid Hormone (PTH)(44-68)(Human)

Parathyroid Hormone (Human, 1-34)

Parathyroid Hormone-Related Protein (PTH-RP)(1-34) (Human, Rat, Mouse)

Parathyroid Hormone-Related Protein (PTH-RP)(107-111)(Human, Rat, Mouse)

Parathyroid Hormone-Related Protein (PTH-RP)(7-34) Amide [Leu11 D-Trp12](Human)