Orphanin FQ(1-11) TFA;
Orphanin FQ(1-11) TFA 是孤儿蛋白 FQ 或 nociceptin (OFQ/N) 片段,是一种有效的NOP 受体 (ORL-1; OP4) 激动剂,Ki 为 55 nM。Orphanin FQ(1-11) TFA 对 μ,δ,κ1 和 κ3 受体没有亲和力 (Ki>1000 nM)。Orphanin FQ(1-11) TFA 在 CD-1 小鼠中具有缓解疼痛作用。
Orphanin FQ(1-11) TFA Chemical Structure
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100 mg |
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250 mg |
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500 mg |
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生物活性 |
Orphanin FQ(1-11) TFA, a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent NOP receptor (ORL-1; OP4) agonist, with a Ki of 55 nM. Orphanin FQ(1-11) TFA has no affinity for μ, δ, κ1 and κ3 receptors (Ki>1000 nM). Orphanin FQ(1-11) TFA is analgesic in CD-1 mice[1][2].
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运输条件 |
Room temperature in continental US; may vary elsewhere.
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis.
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参考文献 |
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[1]. Reinscheid RK, et al. Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J Biol Chem. 1996;271(24):14163-14168.
[2]. Rossi GC, et al. Pharmacological characterization of orphanin FQ/nociceptin and its fragments. J Pharmacol Exp Ther. 1997;282(2):858-865.
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