标签归档：nls

NLS (PKKKRKV) (TFA)

发表于由

NLS (PKKKRKV) (TFA);

NLS (PKKKRKV) TFA 是一种源于 SV40 large T antigen 的 NLS ，可作为增强核进入方法应用于基因导入。

NLS (PKKKRKV) (TFA)amp;;

NLS (PKKKRKV) (TFA) Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

NLS (PKKKRKV) (TFA) 的其他形式现货产品:

NLS (PKKKRKV) (hydrochloride)

生物活性

NLS (PKKKRKV) TFA is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen). NLS (PKKKRKV) TFA can function as a method to enhance nuclear entry in the field of gene transfer research[1][2].

体外研究
(In Vitro)

NLS (PKKKRKV) TFA is the minimum nuclear localization signals (NLS) of SV40 T antigen[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

997.16

Formula

C42H79F3N14O10
Sequence Shortening

PKKKRKV
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zanta MA, et al. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):91-6.

    [2]. Cao S, et al. Enhanced effect of nuclear localization signal peptide during ultrasound-targeted microbubble destruction-mediated gene transfection. Mol Med Rep. 2017 Jul;16(1):565-572.

NLS (PKKKRKV)

发表于由

NLS (PKKKRKV);

NLS (PKKKRKV) 是一种源于 SV40 large T antigen 的 NLS，可作为增强核进入方法应用于基因导入。

NLS (PKKKRKV)amp;;

NLS (PKKKRKV) Chemical Structure

CAS No. : 95088-49-6

规格 价格 是否有货
1 mg ￥1000 询问价格 货期
5 mg ￥2500 询问价格 货期
10 mg ￥4250 询问价格 货期

* Please select Quantity before adding items.

NLS (PKKKRKV) 的其他形式现货产品:

NLS (PKKKRKV) (hydrochloride)

生物活性

NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen). NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research[1][2].

分子量

883.14

Formula

C40H78N14O8
CAS 号

95088-49-6
Sequence Shortening

PKKKRKV
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zanta MA, et al. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):91-6.

    [2]. Cao S, et al. Enhanced effect of nuclear localization signal peptide during ultrasound-targeted microbubble destruction-mediated gene transfection. Mol Med Rep. 2017 Jul;16(1):565-572.

NLS-StAx-h

发表于由

NLS-StAx-h;

NLS-StAx-h 是选择性的 Wnt 信号传导的固定肽抑制剂，IC50 为 1.4 μM。NLS-StAx-h 有效抑制 β-catenin-转录因子的相互作用。NLS-StAx-h 抑制结直肠癌细胞的增殖和迁移。

NLS-StAx-hamp;;

NLS-StAx-h Chemical Structure

规格 是否有货
100 μg 询价

* Please select Quantity before adding items.

生物活性

NLS-StAx-h is a selective, stapled peptide inhibitor of Wnt signaling with an IC50 of 1.4 μM. NLS-StAx-h efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h inhibits proliferation and migration of colorectal cancer cells[1].

IC50 Target[1]

Wnt

1.4 mu;M (IC50)

体外研究
(In Vitro)

NLS-StAx-h (10 μM, 72 hr) reduces the viability of both SW-480 and DLD-1 by more than 80%. NLS-StAx-h results in gene expression changes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3445.26

Formula

C53H100N19O10V2W
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Laura Dietrich, et al. Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling That Targets β-Catenin Protein-Protein Interactions

Cas9 Nuclease Protein Nls Cas9核酸蛋白NLS 品牌：Nippon Gene

发表于由

Cas9 Nuclease Protein Nls

Cas9核酸蛋白NLS

品牌：Nippon Gene
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

313-08421

 – 50 ug –

Cas9 Nuclease Protein Nls Cas9核酸蛋白NLS 品牌：Nippon Gene

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Cas9 Nuclease Protein Nls (High Conc.) Cas9核酸蛋白NLS（高浓） 品牌：Nippon Gene

发表于由

Cas9 Nuclease Protein Nls (High Conc.)

Cas9核酸蛋白NLS（高浓）

品牌：Nippon Gene
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

317-08441

 – 75 ug –

Cas9 Nuclease Protein Nls (High Conc.) Cas9核酸蛋白NLS（高浓） 品牌：Nippon Gene

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

NLS (PKKKRKV) (hydrochloride)

发表于由

NLS (PKKKRKV) (hydrochloride); 纯度: 98.01%

NLS (PKKKRKV) hydrochloride 是一种源于 SV40 大 T 抗原的 NLS，可作为增强核进入方法应用于基因导入。

NLS (PKKKRKV) (hydrochloride)amp;;

NLS (PKKKRKV) (hydrochloride) Chemical Structure

规格 价格 是否有货 数量
5 mg ￥900 In-stock
10 mg ￥1500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

NLS (PKKKRKV) hydrochloride is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen). NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research[1][2].

分子量

919.60

Formula

C40H79ClN14O8
Sequence

Pro-Lys-Lys-Lys-Arg-Lys-Val
Sequence Shortening

PKKKRKV
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro:;

H2O : 500 mg/mL (543.71 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0874 mL 5.4371 mL 10.8743 mL
5 mM 0.2175 mL 1.0874 mL 2.1749 mL
10 mM 0.1087 mL 0.5437 mL 1.0874 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Zanta MA, et al. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):91-6.

    [2]. Cao S, et al. Enhanced effect of nuclear localization signal peptide during ultrasound-targeted microbubble destruction-mediated gene transfection. Mol Med Rep. 2017 Jul;16(1):565-572.

Cas9 Nuclease protein NLS (3μg/μl) 品牌：Nippon Gene

发表于由

Cas9 Nuclease protein NLS (3μg/μl)

品牌：Nippon Gene
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

319-08641

 – 75μg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Cas9 Nuclease protein NLS (15μg/μl) 品牌：Nippon Gene

发表于由

Cas9 Nuclease protein NLS (15μg/μl)

品牌：Nippon Gene
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

316-08651

 – 300μg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。