Leu-NH2 HCl 品牌：Peptide

发表于2024年10月17日由Whatman官网

Leu-NH2 HCl

品牌：Peptide
CAS No.：10466-61-2
储存条件：2-10℃
纯度：–

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
337-30271	–	0.1g	–	咨询	–	–

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VKGILS-NH2 TFA

发表于2024年10月10日由Whatman官网

VKGILS-NH2 TFA;

VKGILS-NH2 TFA 是一种 SLIGKV-NH2 (蛋白酶激活的受体 2 (PAR2) 的激动剂) 的反向氨基酸序列对照肽，对细胞中的 DNA 合成没有影响。

VKGILS-NH2 TFA Chemical Structure

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VKGILS-NH2 TFA 的其他形式现货产品:

VKGILS-NH2

生物活性	VKGILS-NH2 TFA is a reversed amino acid sequence control peptide for SLIGKV-NH2 (protease-activated receptor 2 (PAR2) agonist). VKGILS-NH2 TFA has no effect on DNA synthesis in cells^[1]^[2].
分子量	728.80
Formula	C₃₀H₅₅F₃N₈O₉
Sequence	Val-Lys-Gly-Ile-Leu-Ser-NH2
Sequence Shortening	VKGILS-NH2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. M Tognetto, et al. Evidence That PAR-1 and PAR-2 Mediate Prostanoid-Dependent Contraction in Isolated Guinea-Pig Gallbladder. Br J Pharmacol. 2000 Oct;131(4):689-94. [2]. David A Vesey, et al. Proinflammatory and Proliferative Responses of Human Proximal Tubule Cells to PAR-2 Activation. Am J Physiol Renal Physiol. 2007 Nov;293(5):F1441-9.

Ac-RYYRWK-NH2 TFA

发表于2024年10月6日由Whatman官网

Ac-RYYRWK-NH2 TFA;

Ac-RYYRWK-NH2 TFA 是一个有效的和选择性 nociceptin receptor (NOP) 部分激动剂。[³H]Ac-RYYRWK-NH2 TFA 结合鼠皮层膜的 ORL1 的K_d 为0.071 nM，但是对 µ-,κ- 或 δ 阿片受体没有亲和力。

Ac-RYYRWK-NH2 TFA Chemical Structure

CAS No. : 408305-09-9

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生物活性	Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [³H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a K_d of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors^[1].
体外研究 (In Vitro)	[3H]ac-RYYRWK-NH2 binding to rat cortical membranes revealed a single high affinity site for [3H]ac-RYYRWK-NH2 (K_d=0.071 nM)^[1]. Naloxone benzoylhydrazone displaced [3H]acRYYRWK-NH2 binding to rat cortical membranes (K_i=104 nM) and human ORL1 (K_i=136 nM) as well as [125I]Tyr14-NC-OH to ORL1 (K_i=37 nM) has no affinity for µ-, κ- or δ-opioid receptors^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	1126.19
Formula	C₅₁H₇₀F₃N₁₅O₁₁
CAS 号	408305-09-9
Sequence Shortening	Ac-RYYRWK-NH2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.J Pharmacol Exp Ther. 1997 Nov;283(2):735-41. [2]. M Ho, et al, Characterization of the ORL(1) receptor on adrenergic nerves in the rat anococcygeus muscle. Br J Pharmacol. 2000 Sep;131(2):349-55.

Alkaline phosphatase labeling kit-nh2 碱性磷酸酶标记检测试剂盒-NH2 品牌：FUJIFILM Wako

发表于2024年9月22日由Whatman官网

Alkaline phosphatase labeling kit-nh2

碱性磷酸酶标记检测试剂盒-NH2

品牌：FUJIFILM Wako
CAS No.：
储存条件：2-10℃
纯度：–

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
349-90873	–	1 test	–	咨询	–	–

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RLLFT-NH2 TFA

发表于2024年9月11日由Whatman官网

RLLFT-NH2 TFA;

RLLFT-NH2 TFA 是一种 TFLLR-NH2 的反向氨基酸序列阴性对照肽。

RLLFT-NH2 TFA Chemical Structure

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生物活性	RLLFT-NH2 TFA is a reversed amino acid sequence negative control peptide for TFLLR-NH2^[1].
分子量	761.83
Formula	C₃₃H₅₄F₃N₉O₈
Sequence	Arg-Leu-Leu-Phe-Thr-NH2
Sequence Shortening	RLLFT-NH2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Michelle C Buresi, et al. Activation of Proteinase-Activated receptor-1 Inhibits Neurally Evoked Chloride Secretion in the Mouse Colon in Vitro. Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G337-45.

HSDVHK-NH2 TFA

发表于2024年9月9日由Whatman官网

HSDVHK-NH2 TFA;

HSDVHK-NH2 TFA 是整合素 αvβ3-玻璃体结合蛋白的互作拮抗剂，其 IC₅₀ 值为 1.74 pg/mL (2.414 pM)。

HSDVHK-NH2 TFA Chemical Structure

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HSDVHK-NH2 TFA 的其他形式现货产品:

HSDVHK-NH2

生物活性

HSDVHK-NH2 TFA is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC₅₀ of 1.74 pg/mL (2.414 pM)^[1]^[2].

体外研究
(In Vitro)

HSDVHK significantly inhibited bFGF-induced cell migration compared to the PBS control group^[1].
The Arg-Gly-Asp (RGD)-binding site recognition by HSDVHK-NH2 (P11) is site specific because the HSDVHK-NH2 (P11) is inactive for the complex formation of a denatured form of integrin–vitronectin. HSDVHK-NH2 (P11) shows a strong antagonism against avb3-GRGDSP interaction with an IC₅₀ value of 25.72 nM^[2].
HSDVHK-NH2 (P11) inhibits the HUVEC proliferation due to the induction of HUVEC cell death through caspases activations and its mechanism is related with increased p53 expression^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[3]

Cell Line:	HUVEC cells.
Concentration:	0.1, 1, 10, and 100 μg/mL.
Incubation Time:	72 h.
Result:	Significantly inhibited HUVEC proliferation on denatured collagen-coated plates in a dose-dependent manner.

分子量

834.80

Formula

C₃₂H₄₉F₃N₁₂O₁₁

Sequence Shortening

HSDVHK-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Yoonsuk Lee, et al. High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip. J Biomol Screen. 2004 Dec;9(8):687-94.

[2]. Youngjin Choi, et al. Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin. Proteomics. 2010 Jan;10(1):72-80.

[3]. Ji-Young Bang, et al. Pharmacoproteomic analysis of a novel cell-permeable peptide inhibitor of tumor-induced angiogenesis. Mol Cell Proteomics. 2011 Aug;10(8):M110.005264.

Ac-RYYRIK-NH2 TFA

发表于2024年9月1日由Whatman官网

Ac-RYYRIK-NH2 TFA;

Ac-RYYRIK-NH2 TFA 是一种有效的 ORL1 部分激动剂，作为 ORL1 的内源性配体，在 CHO 细胞中 (K_d=1.5 nM)。Ac-RYYRIK-NH2 TFA 是 G 蛋白激活的特异性拮抗剂，竞争性拮抗 noc/OFQ 在大鼠脑膜和脑切面刺激 [³⁵S]-GTPgS 结合 G 蛋白。

Ac-RYYRIK-NH2 TFA Chemical Structure

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生物活性	Ac-RYYRIK-NH2 TFA is a potent and partial agonist on ORL1 transfected in CHO cells (K_d=1.5 nM) and behaves as a endogenous ligand of ORL1. Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [³⁵S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain^[1].
IC₅₀ Target	Kd: 1.5 nM (ORL1 in CHO cells)^[1]
体内研究 (In Vivo)	Ac-RYYRIK-NH2 TFA (intracerebroventricularly (i.c.v.)) inhibits spontaneous locomotor activity in mice with an ID₅₀ of 0.07 nmol. Co-administration of noc/OFQ and Ac-RYYRIK-NH2 lead to additive effects in Male Swiss mice^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	1053.13
Formula	C₄₆H₇₁F₃N₁₄O₁₁
Sequence Shortening	Ac-RYYRIK-NH2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. H Berger, et al. Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ. Br J Pharmacol. 1999 Feb;126(3):555-8. [2]. H Berger, et al. The nociceptin/orphanin FQ receptor ligand acetyl-RYYRIK-amide exhibits antagonistic and agonistic properties.Peptides. 2000 Jul;21(7):1131-9. [3]. C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J Pharmacol Exp Ther. 1997 Nov;283(2):735-41.

K-(D-1-Nal)-FwLL-NH2

发表于2024年8月11日由Whatman官网

K-(D-1-Nal)-FwLL-NH2;

K-(D-1-Nal)-FwLL-NH2 是一种高亲和力、强效、反向的 ghrelin receptor 激动剂 (EC₅₀=3.4 nM； K_i=4.9 nM)。K-(D-1-Nal)-FwLL-NH2 可用于肥胖研究。

K-(D-1-Nal)-FwLL-NH2 Chemical Structure

CAS No. : 1394288-22-2

规格		是否有货
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生物活性	K-(D-1-Nal)-FwLL-NH2 is a high affinity, potent and inverse ghrelin receptor agonist (EC₅₀=3.4 nM, K_i=4.9 nM). K-(D-1-Nal)-FwLL-NH2 can be used for the research of obesity^[1].
IC₅₀ Target	EC50: 3.4 nM (ghrelin receptor), Ki: 4.9 nM (ghrelin receptor)^[1]
分子量	902.13
Formula	C₅₁H₆₇N₉O₆
CAS 号	1394288-22-2
Sequence Shortening	K{Nal}FWLL-NH2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Els S, et al. An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J Med Chem. 2012;55(17):7437-7449.

SLIGRL-NH2 TFA(Synonyms: Protease-Activated Receptor-2 Activating Peptide TFA)

发表于2024年8月8日由Whatman官网

SLIGRL-NH2 TFA;(Synonyms: Protease-Activated Receptor-2 Activating Peptide TFA)

SLIGRL-NH2 TFA (Protease-Activated Receptor-2 Activating Peptide TFA) 是一种蛋白酶激活受体-2 (PAR-2) 激动剂。

SLIGRL-NH2 TFAamp;;(Synonyms: Protease-Activated Receptor-2 Activating Peptide TFA)

SLIGRL-NH2 TFA Chemical Structure

规格		是否有货
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250 mg	;	询价	;
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SLIGRL-NH2 TFA 的其他形式现货产品:

SLIGRL-NH2

生物活性

SLIGRL-NH2 TFA (Protease-Activated Receptor-2 Activating Peptide TFA) is an agonist of Protease-Activated Receptor-2 (PAR-2)^[1].

IC₅₀ Target

PAR-2^[1]

体外研究
(In Vitro)

SLIGRL-NH2 is an agonist of PAR-2 and MrgprC11^[1]. SLIGRL-NH2 causes an L-NAME-inhibited relaxation. Based on SLIGRL-NH₂ causing a concentration-dependent relaxation with an EC₅₀ of 10 µM in endothelium-free preparations in the presence of perivascular adipose tissue (PVAT) , 20 µM is used as a suitable ‘test’ concentration of peptide in subsequent experiments designed to evaluate the effects of potential inhibitors of ADRF release/action. In the endothelium-free aorta preparations, SLIGRL-NH2 causes a concentration-dependent relaxation in preparations only in the presence of PVAT [+PVAT, -ENDO (endothelium)]^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

770.84

Formula

C₃₁H₅₇F₃N₁₀O₉

Sequence

Ser-Leu-Ile-Gly-Arg-Leu-NH2

Sequence Shortening

SLIGRL-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Akiyama T, et al. Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlativeresponses of lumbar dorsal horn neurons in the mouse. Neuroscience. 2014 Apr 25;266:38-46.

[2]. Li Y, et al. Perivascular adipose tissue-derived relaxing factors: release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms. Br J Pharmacol. 2011 Dec;164(8):1990-2002.

FSLLRY-NH2

发表于2024年8月2日由Whatman官网

FSLLRY-NH2;

FSLLRY-NH2 是蛋白酶激活受体2 (PAR2)抑制剂。

FSLLRY-NH2 Chemical Structure

CAS No. : 245329-02-6

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

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FSLLRY-NH2 的其他形式现货产品:

FSLLRY-NH2 TFA

生物活性	FSLLRY-NH2 is a protease-activated receptor 2 (PAR2) inhibitor^[1].
体内研究 (In Vivo)	Treatment with FSLLRY-NH2 (50 μg per rat administered intranasally at 1 hour postresuscitation) significantly improves neurological outcome and reduces the number of degenerating hippocampal neurons after ACA (asphyxial CA)^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	796.96
Formula	C₃₉H₆₀N₁₀O₈
CAS 号	245329-02-6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Umut Ocak, et al. FSLLRY-NH2 Improves Neurological Outcome After Cardiac Arrest in Rats. Turk Neurosurg. 2020;30(2):244-251.

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标签归档：nh

Leu-NH2 HCl 品牌：Peptide

Leu-NH2 HCl

VKGILS-NH2 TFA

Ac-RYYRWK-NH2 TFA

Alkaline phosphatase labeling kit-nh2 碱性磷酸酶标记检测试剂盒-NH2 品牌：FUJIFILM Wako

Alkaline phosphatase labeling kit-nh2

碱性磷酸酶标记检测试剂盒-NH2

RLLFT-NH2 TFA

HSDVHK-NH2 TFA

Ac-RYYRIK-NH2 TFA

K-(D-1-Nal)-FwLL-NH2

SLIGRL-NH2 TFA(Synonyms: Protease-Activated Receptor-2 Activating Peptide TFA)

FSLLRY-NH2

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