Anti-CML, Mouse-Mono (NF-1G), Biotin 品牌:Transgenic


Anti-CML, Mouse-Mono (NF-1G), Biotin

品牌:Transgenic
CAS No.:
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

KH024-01

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Lucyoside B

天然产物 糖类和糖苷 Saccharides and Glycosides

Lucyoside B;

Lucyoside B 在活化的巨噬细胞中通过 NF-κB 和激活因子蛋白-1途径抑制炎症介质的产生。

Lucyoside B

Lucyoside B Chemical Structure

CAS No. : 91174-19-5

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生物活性

Lucyoside B inhibits the production of inflammatory mediators via both NF-κB and activator protein-1 pathways in activated macrophages[1].

分子量

812.98

Formula

C42H68O15

CAS 号

91174-19-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yixin Han, et al.Lucyoside B, a triterpenoid saponin from Luffa cylindrica, inhibits the production of inflammatory mediators via both nuclear factor-κB and activator protein-1 pathways in activated macrophages.Journal of Functional Foods,Volume 69, June

Helenalin

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Helenalin  纯度: 98.87%

Helenalin 是一种抗炎的倍半萜内酯。Helenalin 通过直接靶向 p65 选择性抑制转录因子 NF-κB。Helenalin 具有烷基化活性,以 NF-κB 的 p65 亚基中的半胱氨酸巯基为靶点,从而抑制其 DNA 结合。

Helenalin

Helenalin Chemical Structure

CAS No. : 6754-13-8

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500 μg ¥3595 In-stock
1 mg ¥5395 In-stock
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Helenalin 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding[1][2].

体外研究
(In Vitro)

Helenalin (10 μM; 20-120 minutes) causes complete inhibition of NF-κB DNA binding after 80 minutes[1].
The anti-inflammatory, anti-carcinogenic phytochemical, Helenalin is a potent inhibitor of periodic Skp2 accumulation, an F-box protein mediating SCF E3 ligase ubiquitylation and degradation of both CKIs during S phase progression[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Jurkat T cells
Concentration: 10 μM
Incubation Time: 20-120 minutes
Result: Caused complete inhibition of NF-κB DNA binding after 80 minutes.

体内研究
(In Vivo)

Helenalin (25 mg/kg; i.p.; 6 to 12 hours) administers to immature male ICR mice caused a rapid decrease in hepatic glutathione levels[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Immature male ICR mice[2]
Dosage: 25 mg/kg
Administration: i.p.; 6 to 12 hours
Result: Caused a rapid decrease in hepatic glutathione levels.

分子量

262.30

Formula

C15H18O4

CAS 号

6754-13-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Merrill JC, et al. Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin. J Toxicol Environ Health. 1988;23(2):159-69.

    [2]. Lyss G, et al. The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65. J Biol Chem. 1998 Dec 11;273(50):33508-16.

    [3]. Fernandes KM, et al. Helenalin-mediated post-transcriptional regulation of p21(Cip1) inhibits 3T3-L1 preadipocyteproliferation. J Cell Biochem. 2008 Oct 15;105(3):913-21.

Nimbolide(Synonyms: 印苦楝内酯)

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Nimbolide (Synonyms: 印苦楝内酯) 纯度: 99.94%

Nimbolide 是一种源自 Azadirachta indica L 叶和花的三萜化合物。Nimbolide 通过抑制 NF-κB 而诱导肿瘤细胞凋亡。 Nimbolide 抑制 CDK4/CDK6 激酶活性。Nimbolide 抑制 NF-κB,Wnt,PI3K-Akt,MAPK 和 JAK-STAT 信号通路。

Nimbolide(Synonyms: 印苦楝内酯)

Nimbolide Chemical Structure

CAS No. : 25990-37-8

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1 mg ¥4500 In-stock
5 mg ¥8200 In-stock
10 mg   询价  
50 mg   询价  

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Nimbolide 相关产品

相关化合物库:

  • Natural Product Library Plus
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生物活性

Nimbolide is a triterpene derived from the leaves and flowers of neem (Azadirachta indica L). Nimbolide induces apoptosis through inactivation of NF-κB. Nimbolide inhibits CDK4/CDK6 kinase activity. Nimbolide suppresses the NF-κB, Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways[1].

IC50 & Target[1]

NF-κB

 

CDK4

 

CDK6

 

分子量

466.52

Formula

C27H30O7

CAS 号

25990-37-8

中文名称

印苦楝内酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
In Vitro: 

DMSO : 50 mg/mL (107.18 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1435 mL 10.7177 mL 21.4353 mL
5 mM 0.4287 mL 2.1435 mL 4.2871 mL
10 mM 0.2144 mL 1.0718 mL 2.1435 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (2.14 mM); Clear solution

    此方案可获得 ≥ 1 mg/mL (2.14 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (2.14 mM); Clear solution

    此方案可获得 ≥ 1 mg/mL (2.14 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Bodduluru LN, et al. Chemopreventive and therapeutic effects of nimbolide in cancer: the underlying mechanisms. Toxicol In Vitro. 2014 Aug;28(5):1026-35.

Gossypin

天然产物 黄酮类 Flavonoids

Gossypin 

Gossypin 是从 Hibiscus vitifolius 中分离得到的一种黄酮,具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病和保护肝脏的活性。Gossypin 抑制 NF-κB 和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中,Gossypin 也可抑制 RANKL 诱导的破骨细胞形成。

Gossypin

Gossypin Chemical Structure

CAS No. : 652-78-8

规格 价格 是否有货
5 mg ¥2200 询问价格 & 货期
10 mg ¥3750 询问价格 & 货期

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生物活性

Gossypin is a flavone isolated from Hibiscus vitifolius and has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, and hepatoprotective activities. Gossypin inhibits NF-κB and NF-κB-regulated gene expression. Gossypin inhibits RANKL-induced osteoclastogenesis both in mouse primary bone marrow cells and RAW 264.7 cells in vitro[1][2].

IC50 & Target

IC50: NF-κB[1]

分子量

480.38

Formula

C21H20O13

CAS 号

652-78-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ajaikumar B Kunnumakkara, et al.  Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. Blood. 2007 Jun 15;109(12):5112-21.

    [2]. Kanika Patel, et al. Gossypin: A phytochemical of multispectrum potential. the Journal of Coastal Life Medicine.

AppliChem 141637.1211 Sodium Benzoate (USP-NF, BP, Ph. Eur.) pure, pharma grade  苯甲酸钠 (USP-NF, BP, Ph. Eur.)药典级532-32-1 1 kg

上海金畔生物科技有限公司提供AppliChem 141637.1211 Sodium Benzoate (USP-NF, BP, Ph. Eur.) pure, pharma grade  苯甲酸钠 (USP-NF, BP, Ph. Eur.)药典级532-32-1 1 kg,欢迎访问官网了解更多产品信息和订购

品牌 货号 产品名称 规格 价格

AppliChem 141637.1211 Sodium Benzoate (USP-NF, BP, Ph. Eur.) pure, pharma grade  苯甲酸钠 (USP-NF, BP, Ph. Eur.)药典级532-32-1 1 kg 1269.00

AppliChem 141637.0914 Sodium Benzoate (USP-NF, BP, Ph. Eur.) pure, pharma grade  苯甲酸钠 (USP-NF, BP, Ph. Eur.)药典级532-32-1 5 kg 5616.00

AppliChem 141632.1214 Sodium Acetate 3-hydrate (USP, BP, Ph. Eur.) pure, pharma grade 三水乙酸钠(USP, BP, Ph. Eur.) 药典级6131-90-4 5 kg 0.00

AppliChem 141632.1211 Sodium Acetate 3-hydrate (USP, BP, Ph. Eur.) pure, pharma grade 三水乙酸钠(USP, BP, Ph. Eur.) 药典级6131-90-4 1 kg 929.00

AppliChem 141632.0416 Sodium Acetate 3-hydrate (USP, BP, Ph. Eur.) pure, pharma grade 三水乙酸钠(USP, BP, Ph. Eur.) 药典级6131-90-4 25 kg 0.00

AppliChem 141545.1214 1,2-Propanediol (USP, BP, Ph. Eur., JP) pure, pharma grade 1,2-丙二醇 (USP, BP, Ph. Eur., JP)纯,药典级 57-55-6 5 L 0.00

AppliChem 141545.1211 1,2-Propanediol (USP, BP, Ph. Eur., JP) pure, pharma grade 1,2-丙二醇 (USP, BP, Ph. Eur., JP)纯,药典级 57-55-6 1 L 1315.00

AppliChem 141545.0718 1,2-Propanediol (USP, BP, Ph. Eur., JP) pure, pharma grade 1,2-丙二醇 (USP, BP, Ph. Eur., JP)纯,药典级 57-55-6 60 L 0.00

AppliChem 141545.0716 1,2-Propanediol (USP, BP, Ph. Eur., JP) pure, pharma grade 1,2-丙二醇 (USP, BP, Ph. Eur., JP)纯,药典级 57-55-6 25 L 0.00

AppliChem 141542.1214 Potassium Iodide (USP, BP, Ph. Eur.) pure, pharma grade 碘化钾 (USP, BP, Ph. Eur.) 药典级7681-11-0 5 kg 34455.00

AppliChem 141542.1211 Potassium Iodide (USP, BP, Ph. Eur.) pure, pharma grade 碘化钾 (USP, BP, Ph. Eur.) 药典级7681-11-0 1 kg 7454.00

AppliChem 141542.1210 Potassium Iodide (USP, BP, Ph. Eur.) pure, pharma grade 碘化钾 (USP, BP, Ph. Eur.) 药典级7681-11-0 500 g 4292.00

AppliChem 141542.1209 Potassium Iodide (USP, BP, Ph. Eur.) pure, pharma grade 碘化钾 (USP, BP, Ph. Eur.) 药典级7681-11-0 250 g 2295.00

AppliChem 141532.1214 Potassium Sulfate pure 硫酸钾7778-80-5 5 kg 3069.00

AppliChem 141532.1210 Potassium Sulfate pure 硫酸钾7778-80-5 500 g 627.00

AppliChem 141531.1211 Potassium Sorbate (BP, Ph. Eur.) pure, pharma grade 山梨酸钾(BP, Ph. Eur.)24634-61-5 1 kg 2122.00

AppliChem 141512.1211 di-Potassium Hydrogen Phosphate anhydrous (BP, Ph. Eur.) pure, pharma grade 磷酸氢二钾无水 7758-11-4 1 kg 1666.00

AppliChem 141512.0914 di-Potassium Hydrogen Phosphate anhydrous (BP, Ph. Eur.) pure, pharma grade 磷酸氢二钾无水 7758-11-4 5 kg 0.00

AppliChem 141512.0416 di-Potassium Hydrogen Phosphate anhydrous (BP, Ph. Eur.) pure, pharma grade 磷酸氢二钾无水 7758-11-4 25 kg 0.00

AppliChem 141509.1214 Potassium di-Hydrogen Phosphate (USP-NF, BP, Ph. Eur.) pure, pharma grade 磷酸二氢钾(USP-NF, BP, Ph. Eur.) 药典级 7778-77-0 5 kg 7957.00

AppliChem 141509.1211 Potassium di-Hydrogen Phosphate (USP-NF, BP, Ph. Eur.) pure, pharma grade 磷酸二氢钾(USP-NF, BP, Ph. Eur.) 药典级 7778-77-0 1 kg

上海金畔生物科技有限公司提供AppliChem 141509.1211 Potassium di-Hydrogen Phosphate (USP-NF, BP, Ph. Eur.) pure, pharma grade 磷酸二氢钾(USP-NF, BP, Ph. Eur.) 药典级 7778-77-0 1 kg,欢迎访问官网了解更多产品信息和订购

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AppliChem 141509.1211 Potassium di-Hydrogen Phosphate (USP-NF, BP, Ph. Eur.) pure, pharma grade 磷酸二氢钾(USP-NF, BP, Ph. Eur.) 药典级 7778-77-0 1 kg 2219.00

AppliChem 141509.1210 Potassium di-Hydrogen Phosphate (USP-NF, BP, Ph. Eur.) pure, pharma grade 磷酸二氢钾(USP-NF, BP, Ph. Eur.) 药典级 7778-77-0 500 g 1537.00

AppliChem 141509.0416 Potassium di-Hydrogen Phosphate (USP-NF, BP, Ph. Eur.) pure, pharma grade 磷酸二氢钾(USP-NF, BP, Ph. Eur.) 药典级 7778-77-0 25 kg 0.00

AppliChem 141490.0416 Potassium Carbonate pure 碳酸钾584-08-7 25 kg 0.00

AppliChem 141479.1211 Potassium Acetate (BP, Ph. Eur.) pure, pharma grade 醋酸钾(BP, Ph. Eur.)纯,药典级127-08-2 1 kg 2428.00

AppliChem 141404.1211 Magnesium Sulfate 7-hydrate (USP, BP, Ph. Eur.) pure, pharma grade 七水硫酸镁 (USP, BP, Ph. Eur.) 纯,药典级10034-99-8 1 kg 720.00

AppliChem 141404.0914 Magnesium Sulfate 7-hydrate (USP, BP, Ph. Eur.) pure, pharma grade 七水硫酸镁 (USP, BP, Ph. Eur.) 纯,药典级10034-99-8 5 kg 1959.00

AppliChem 141404.0416 Magnesium Sulfate 7-hydrate (USP, BP, Ph. Eur.) pure, pharma grade 七水硫酸镁 (USP, BP, Ph. Eur.) 纯,药典级10034-99-8 25 kg 0.00

AppliChem 141396.1211 Magnesium Chloride 6-hydrate (BP, Ph. Eur.) pure, pharma grade 六水氯化镁 (BP, Ph. Eur.) 纯,药典级7791-18-6 1 kg 735.00

AppliChem 141396.0914 Magnesium Chloride 6-hydrate (BP, Ph. Eur.) pure, pharma grade 六水氯化镁 (BP, Ph. Eur.) 纯,药典级7791-18-6 5 kg 2360.00

AppliChem 141396.0416 Magnesium Chloride 6-hydrate (BP, Ph. Eur.) pure, pharma grade 六水氯化镁 (BP, Ph. Eur.) 纯,药典级7791-18-6 25 kg 0.00

AppliChem 141375.1211 D(+)-Lactose 1-hydrate (USP-NF, BP, Ph. Eur.) pure, pharma grade 一水乳糖(USP-NF, BP, Ph. Eur.) 纯,药典级10039-26-6 1 kg 973.00

AppliChem 141375.0914 D(+)-Lactose 1-hydrate (USP-NF, BP, Ph. Eur.) pure, pharma grade 一水乳糖(USP-NF, BP, Ph. Eur.) 纯,药典级10039-26-6 5 kg 2740.00

AppliChem 141362.1214 Iron(II) Sulfate 7-hydrate (USP, BP, Ph. Eur.) pure, pharma grade 七水硫酸亚铁(USP, BP, Ph. Eur.) 纯,药典级7782-63-0 5 kg 2377.00

AppliChem 141362.1210 Iron(II) Sulfate 7-hydrate (USP, BP, Ph. Eur.) pure, pharma grade 七水硫酸亚铁(USP, BP, Ph. Eur.) 纯,药典级7782-63-0 500 g 777.00

AppliChem 141362.0416 Iron(II) Sulfate 7-hydrate (USP, BP, Ph. Eur.) pure, pharma grade 七水硫酸亚铁(USP, BP, Ph. Eur.) 纯,药典级7782-63-0 25 kg 0.00

AppliChem 141360.1214 Iron(III) Sulfate x-hydrate ~ 75% pure 聚合硫酸铁10028-22-5 5 kg 6310.00

AppliChem 141360.1210 Iron(III) Sulfate x-hydrate ~ 75% pure 聚合硫酸铁10028-22-5 500 g 1469.00

AppliChem 141341.1211 D(+)-Glucose anhydrous (USP, BP, Ph. Eur.) pure, pharma grade 葡萄糖无水 (USP, BP, Ph. Eur.) 纯,药典级 50-99-7 1 kg 1189.00

AppliChem 141341.0914 D(+)-Glucose anhydrous (USP, BP, Ph. Eur.) pure, pharma grade 葡萄糖无水 (USP, BP, Ph. Eur.) 纯,药典级 50-99-7 5 kg 3827.00

NF-κB inhibitor SN50 品牌:FUJIFILM Wako


NF-κB inhibitor SN50

品牌:FUJIFILM Wako
CAS No.:
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

145-06761

for Biochemistry 500ug 3,700.00


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

anti-NF-kappa-B p65 (human), Rabbit Monoclonal (RM273) 抗NF-κ-B p65 (人), 兔单克隆抗体 (RM273) 品牌:RevMab


anti-NF-kappa-B p65 (human), Rabbit Monoclonal (RM273)

抗NF-κ-B p65 (人), 兔单克隆抗体 (RM273)

品牌:RevMab
CAS No.:
储存条件:-20°C
纯度:Protein A purified.
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

REV-31-1154-00-R100

100 µl 5,390.00


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

HSC70/HSP70 monoclonal antibody (N27F3-4) 热休克同源蛋白HSC70/热休克蛋白HSP70单克隆抗体(N27F3-4) 品牌:Enzo


HSC70/HSP70 monoclonal antibody (N27F3-4)

热休克同源蛋白HSC70/热休克蛋白HSP70单克隆抗体(N27F3-4)

品牌:Enzo
CAS No.:
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

ENZ-ABS716-0050

50 µg 4,400.00


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* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。