标签归档：nep

NEP(1-40) TFA

发表于由

NEP(1-40) TFA;

NEP(1-40) TFA 是 Nogo-66 受体 (NgR) 的肽类拮抗剂，通过限制髓蛋白抑制逆转损伤引起的小胶质细胞形态分布的改变。

NEP(1-40) TFAamp;;

NEP(1-40) TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

NEP(1-40) TFA is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition[1].

体内研究
(In Vivo)

NEP(1-40) (89 μg/kg, ip, 15 min and 19 h post-injury) administration further shifts distributions of microglia away from an injury-induced activated morphology towards greater proportions of rod and macrophage-like morphologies[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 74 male Sprague-Dawley rats (328-377 g)[1].
Dosage: 89 μg/kg (97.5% PBS and 2.5% DMSO).
Administration: IP, 15 min and 19 h post-injury.
Result: Reduced NgR function immediately post-injury.
Increased number of amoeboid microglia/macrophages at 2 days post-injury

分子量

4739.13

Formula

C208H325F3N56O67
Sequence

Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH2
Sequence Shortening

RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jenna M Ziebell, et al. Nogo Presence Is Inversely Associated With Shifts in Cortical Microglial Morphology Following Experimental Diffuse Brain Injury. Neuroscience. 2017 Sep 17;359:209-223.

荧光染料NEP(Synonyms: VDP-green (NEP))

发表于由

荧光染料Dye Reagents NEP;(Synonyms: VDP-green (NEP))

NEP (VDP-green (NEP)) 是一种基于分子内电荷转移 (ICT) 机制的感应荧光探针，用于感应含邻二硫醇的蛋白质 (VDPs)。NEP 在活细胞和动物体内对 VDPs 表现出高选择性，并显示强绿色荧光信号 (λex/λem=430/535 nm)。NEP 具有用于帕金森氏症研究的潜力。

NEP(Synonyms: VDP-green (NEP))

NEP Chemical Structure

CAS No. : 2414276-32-5

规格 价格 是否有货
5 mg ￥3500 询问价格 货期
10 mg ￥5800 询问价格 货期

* Please select Quantity before adding items.

生物活性

NEP (VDP-green (NEP)) is a turn-on fluorescent probe based on the intramolecular charge transfer (ICT) mechanism for sensing vicinal dithiol-containing proteins (VDPs). NEP exhibits high selectivity toward VDPs in live cells and in vivo and displays a strong green fluorescence signal (λex/λem=430/535 nm). NEP has the potential for parkinsonism[1].

体外研究
(In Vitro)

NEP (1-30 μM; 6 hours) has no or little cytotoxicity in HepG2 and PC12 cells[1].
NEP (10 μM; 4 hours) causes the fluorescence intensity to decrease gradually in PC12 cells pretreated with 6-OHDA (0, 50, 100, and 200 μM; for 30 min)[1].
NEP contains a dithiarsolane moiety (five-membered As-S ring) as the receptor of VDPs. In the presence of VDPs, NEP displays a strong green fluorescence signal produced by the cyclic dithiarsolane cleavage and subsequent intramolecular cyclization to liberate the fluorophore. NEP maintains a reliable fluorescence response within the range of pH 7-10[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

NEP (10 μM; for 4 h) causes the obvious green signal in zebrafishes (4 day old)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

654.63

Formula

C29H31AsN4O5S2
CAS 号

2414276-32-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Guodong Hu, et al. Decrease of Protein Vicinal Dithiols in Parkinsonism Disclosed by a Monoarsenical Fluorescent Probe. Anal Chem. 2020 Mar 17;92(6):4371-4378.

NEP 1-40 品牌：Anygen

发表于由

NEP 1-40

品牌：Anygen
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

303-37193

 – 0.5 mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

NEP(1-40)

发表于由

NEP(1-40);

NEP(1-40) 是 Nogo-66 受体 (NgR) 的肽类拮抗剂，通过限制髓蛋白抑制逆转损伤引起的小胶质细胞形态分布的改变。

NEP(1-40)amp;;

NEP(1-40) Chemical Structure

CAS No. : 475221-20-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

NEP(1-40) is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition[1].

体内研究
(In Vivo)

NEP(1-40) (89 μg/kg, ip, 15 min and 19 h post-injury) administration further shifts distributions of microglia away from an injury-induced activated morphology towards greater proportions of rod and macrophage-like morphologies[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 74 male Sprague-Dawley rats (328-377 g)[1].
Dosage: 89 μg/kg (97.5% PBS and 2.5% DMSO).
Administration: IP, 15 min and 19 h post-injury.
Result: Reduced NgR function immediately post-injury.
Increased number of amoeboid microglia/macrophages at 2 days post-injury

分子量

4625.11

Formula

C206H324N56O65
CAS 号

475221-20-6
Sequence

Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH2
Sequence Shortening

RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jenna M Ziebell, et al. Nogo Presence Is Inversely Associated With Shifts in Cortical Microglial Morphology Following Experimental Diffuse Brain Injury. Neuroscience. 2017 Sep 17;359:209-223.