标签归档：nal

K-(D-1-Nal)-FwLL-NH2

发表于由

K-(D-1-Nal)-FwLL-NH2;

K-(D-1-Nal)-FwLL-NH2 是一种高亲和力、强效、反向的 ghrelin receptor 激动剂 (EC50=3.4 nM； Ki=4.9 nM)。K-(D-1-Nal)-FwLL-NH2 可用于肥胖研究。

K-(D-1-Nal)-FwLL-NH2amp;;

K-(D-1-Nal)-FwLL-NH2 Chemical Structure

CAS No. : 1394288-22-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

K-(D-1-Nal)-FwLL-NH2 is a high affinity, potent and inverse ghrelin receptor agonist (EC50=3.4 nM, Ki=4.9 nM). K-(D-1-Nal)-FwLL-NH2 can be used for the research of obesity[1].

IC50 Target

EC50: 3.4 nM (ghrelin receptor), Ki: 4.9 nM (ghrelin receptor)[1]
分子量

902.13

Formula

C51H67N9O6
CAS 号

1394288-22-2
Sequence Shortening

K{Nal}FWLL-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Els S, et al. An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J Med Chem. 2012;55(17):7437-7449.

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)

发表于由

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal);

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) (compound 40) 是 Ape13 的大环类似物，一种有效的 APJ 激动剂 (Ki=5.7 nM)。NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) 表现出有利的 Gα12 偏向信号传导和延长的体内半衰期。

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)amp;;

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) Chemical Structure

规格 是否有货
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250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) (compound 40), a macrocyclic analogue of Ape13, is a potent APJ agonist (Ki=5.7 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) exhibits a favorable Gα12-biased signaling and an increased in vivo half-life[1].

IC50 Target

APJ[1]
分子量

1020.18

Formula

C49H73N13O11
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tran K, et, al. Size-Reduced Macrocyclic Analogues of [Pyr 1]-apelin-13 Showing Negative Gα 12 Bias Still Produce Prolonged Cardiac Effects. J Med Chem. 2022 Jan 13;65(1):531-551.

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal]

发表于由

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal];

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal] (Compound 9C) 对耐药革兰氏阳性菌和革兰氏阴性菌具有广谱活性，对于 MRSA (ATCC BAA-1556)，S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), 和 E. coli (ATCC 25922) 的 MIC 分别为 3.1、3,1、12.5 和 25 μg/mL。

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal]amp;;

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal] Chemical Structure

CAS No. : 2619854-01-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal] (Compound 9C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 25 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively[1].

分子量

1216.44

Formula

C63H81N19O7
CAS 号

2619854-01-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Sandeep Lohan, et al. Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. J Med Chem. 2022 Jan 13;65(1):665-687.

K-(D-1-Nal)-FwLL-NH2 TFA

发表于由

K-(D-1-Nal)-FwLL-NH2 TFA;

K-(D-1-Nal)-FwLL-NH2 TFA is a high affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). K-(D-1-Nal)-FwLL-NH2 blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.

K-(D-1-Nal)-FwLL-NH2 TFAamp;;

K-(D-1-Nal)-FwLL-NH2 TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

K-(D-1-Nal)-FwLL-NH2 TFA is a high affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). K-(D-1-Nal)-FwLL-NH2 blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.

分子量

1016.15

Formula

C53H68F3N9O8
Sequence Shortening

K{Nal}FWLL-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Cyclic-[Mpr3,Nle4,Arg5,D-Nal7,Cys11-Amide]-alpha-MSH (3-11) / JKC-366 品牌：Anygen

发表于由

Cyclic-[Mpr3,Nle4,Arg5,D-Nal7,Cys11-Amide]-alpha-MSH (3-11) / JKC-366

品牌：Anygen
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

304-89971

 – 0.5 mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

[Ac-K0,D-Nal7,I8,Des-R9]-Bradykinin 品牌：Anygen

发表于由

[Ac-K0,D-Nal7,I8,Des-R9]-Bradykinin

品牌：Anygen
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

309-89421

 – 0.5 mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。