MR 409;
MR 409 是一种选择性的生长激素释放激素 (GHRH) 激动剂。MR 409 通过增强脑缺血小鼠的内源性神经发生而具有显著的神经保护作用。MR 409 还可以抑制肺癌的体内生长。
MR 409 Chemical Structure
CAS No. : 1445155-39-4
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| 生物活性 |
MR 409 is a selected growth hormone-releasing hormone (GHRH) agonist. MR 409 has remarkable neuroprotective effects through enhancing endogenous neurogenesis in cerebral ischemic mice. MR 409 also inhibits the in vivo growth of lung cancer[1][2][3][4]. |
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| 体外研究 (In Vitro) |
One week post-myocardial infarction (MI), MR 409 (MR-409) significantly reduces plasma levels of IL-2, IL-6, IL-10 and TNF-α compared to placebo[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[2]
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| 体内研究 (In Vivo) |
MR 409 (MR-409) inhibits the in vivo growth of lung cancer xenografted into nude mice[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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| 分子量 |
3395.91 |
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| Formula |
C153H252N44O43 |
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| CAS 号 |
1445155-39-4 |
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| Sequence Shortening |
{N-Me}-Y-{D-Ala}-DAIFTNSYR-{Orn}-VL-{Abu}-QLSAR-{Orn}-LLQDI-{Nle}-DR-NHMe |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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