MCL0020;
MCL0020 是一种有效的选择性黑素皮质素 MC4 受体拮抗剂,IC50 为 11.63 nM。MCL0020 具有剂量依赖性,可显著减轻束缚应激诱发的厌食症,且不影响食物摄入。
MCL0020 Chemical Structure
CAS No. : 475498-26-1
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生物活性 |
MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake[1]. |
IC50 Target |
IC50: 11.63 (MC4) |
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体外研究 (In Vitro) |
MCL0020 inhibited [125I][N1e4, D-Phe7]α-MSH binding to membranes of COS-1 cells with IC50 values of 11.63[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
体内研究 (In Vivo) |
MCL0020 attenuates swim stress-induced anxiogeniclike behavior in light/dark exploration tests in mice[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
609.72 |
Formula |
C34H39N7O4 |
CAS 号 |
475498-26-1 |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
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