标签归档：margatoxin

Margatoxin(Synonyms: 玛格斑蝎毒素)

发表于由

Margatoxin;(Synonyms: 玛格斑蝎毒素) 纯度: 99.36%

Margatoxin 是一种 α-KTx 蝎毒素，一种高亲和力的 Kv1.3 抑制剂，Kd 为 11.7 pM。Margatoxin 抑制 Kv1.2 和 Kv1.1 通道，Kd 值分别为 6.4 pM，4.2 nM。Margatoxin 是一种 39 个氨基酸的肽，是从玛格丽特蝎 (Centruroides margaritatus) 蝎毒中分离得到的，广泛用于离子通道研究。

Margatoxinamp;;(Synonyms: 玛格斑蝎毒素)

Margatoxin Chemical Structure

CAS No. : 145808-47-5

规格 价格 是否有货 数量
100 μg ￥1500 In-stock
500 μg ￥4600 In-stock
1 mg ￥6800 In-stock
5 mg ; 询价 ;
10 mg ; 询价 ;

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生物活性

Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research[1][2].

IC50 Target

Kd: 11.7 pM (Kv1.3), 6.4 pM (Kv1.2) and 4.2 nM (Kv1.1)[1]
体内研究
(In Vivo)

Margatoxin (i.p.; 1 pmol/g) significantly decreases thiogycollate-induced leukocyte transmigration in the peritoneal cavity in 12-week-old C57BL6/J mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

4178.95

Formula

C178H286N52O50S7
CAS 号

145808-47-5
Sequence

Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His (Disulfide bridge:Cys7-Cys29;Cys13-Cys34;Cys17-Cys36)
Sequence Shortening

TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH(Disulfide bridge:Cys7-Cys29;Cys13-Cys34;Cys17-Cys36)
中文名称

玛格斑蝎毒素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Protect from light, stored under nitrogen

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen)
参考文献

  • [1]. Bartok A, et al. Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels. Toxicon. 2014 Sep;87:6-16.

    [2]. Chen YC, et al. PreImplantation factor prevents atherosclerosis via its immunomodulatory effects without affecting serum lipids. Thromb Haemost. 2016 May 2;115(5):1010-24.

Margatoxin (MgTX) 斑蝎毒素 品牌：Peptide

发表于由

Margatoxin (MgTX)

斑蝎毒素

品牌：Peptide
CAS No.：145808-47-5
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

331-42901

 – 0.1mg – 咨询 – –


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