标签归档：kv

Kv3, Channel Containing Protein (567-585)

发表于由

Kv3, Channel Containing Protein (567-585);

Kv3, Channel Containing Protein (567-585) 是Kv3.1b 通道蛋白的567-586 氨基酸肽。Kv3 channel protein 在含有pallidal 神经元的 PV 蛋白表达。

Kv3, Channel Containing Protein (567-585)amp;;

Kv3, Channel Containing Protein (567-585) Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Kv3, Channel Containing Protein (567-585) corresponds to amino acids 567 to 585 fragment of the Kv3.1b channel containing protein. Kv3 channel protein is expressed by parvalbumin (PV)-containing pallidal neurons [1].

分子量

2122.50

Formula

C93H156N24O28S2
Sequence

Cys-Lys-Glu-Ser-Pro-Val-Ile-Ala-Lys-Tyr-Met-Pro-Thr-Glu-Ala-Val-Arg-Val-Thr
Sequence Shortening

CKESPVIAKYMPTEAVRVT
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Hernández-Pineda R, et al. Kv3.1-Kv3.2 channels underlie a high-voltage-activating component of the delayed rectifier K+ current in projecting neurons from the globus pallidus. J Neurophysiol. 1999 Sep;82(3):1512-28.

Guangxitoxin 1E

发表于由

Guangxitoxin 1E;

Guangxitoxin 1E 是 KV2.1 和 KV2.2 通道的有效选择性阻断剂。Guangxitoxin 1E 抑制 KV2， 其 IC50 值为 1-3 nM，KV2 通道是各种神经元中延迟整流器钾电流的基础。

Guangxitoxin 1Eamp;;

Guangxitoxin 1E Chemical Structure

CAS No. : 1233152-82-3

规格 是否有货
100 μg 询价

* Please select Quantity before adding items.

生物活性

Guangxitoxin 1E is a potent and selective blocker of KV2.1 and KV2.2 channels. Guangxitoxin 1E inhibits KV2 with an IC50 of 1-3 nM. KV2 channels underlie delayed-rectifier potassium currents in various neurons[1][2].

IC50 Target

IC50: 1-3 nM (KV2 channels); 24-54 nM (KV4.3 channels)[2]
体外研究
(In Vitro)

Guangxitoxin 1E inhibits KV2 with an IC50 of 1-3 nM but has no significant effect on KV1.2, KV1.3, KV1.5, KV3.2 and BK potassium channels, nor on calcium and sodium channels CaV1.2, CaV2.2, NaV1.5, NaV1.7, NaV1.8, whereas the IC50 for KV4.3 channels is 24-54 nM[2].
In mouse β-cells, Guangxitoxin 1E inhibits 90% of IDR and, as for KV2.1, shifts the voltage dependence of channel activation to more depolarized potentials, a characteristic of gating-modifier peptides. Guangxitoxin 1E broadens theβ-cell action potential, enhances glucose-stimulated intracellular calcium oscillations, and enhances insulin secretion from mouse pancreatic islets in a glucose-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3948.61

Formula

C178H248N44O45S7
CAS 号

1233152-82-3
Sequence Shortening

EGECGGFWWKCGSGKPACCPKYVCSPKWGLCNFPMP(Disulfide bridge:Cys4-Cys19;Cys11-Cys24;Cys18-Cys31)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hönigsperger C, et al. Physiological roles of Kv2 channels in entorhinal cortex layer II stellate cells revealed by Guangxitoxin-1E. J Physiol. 2017 Feb 1;595(3):739-757.

    [2]. Herrington J, et al. Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes. 2006 Apr;55(4):1034-42.

Oxford牛津80Kv一体化X射线源

发表于由
Oxford牛津80Kv一体化X射线源

Oxford牛津80Kv一体化X射线源

产品编号：
市场价：￥0.00元
会员价：￥0.00元
品牌：Oxford牛津
生产厂家：Oxford牛津
需求数量：

  • 产品概览
  • 技术参数
  • 订购信息
  • 相关资料
  • 相关产品

Oxford牛津80Kv一体化X射线源

80kV 系列是一体化的X光管和集成电源，它集合了1500系列焦点为50微米X光管的特性。
80kV系列的X光管特别为X射线成像应用而设计，其特点是精密的设计具有极高稳定性，可提供更精良品质的成像。同时提供计算机控制界面。

阳极电流 最大10-250 微安
阳极(靶)电压 35—80千伏
最大功率 15瓦
灯丝电压 最大3.0伏@75千伏每2mA
灯丝电流 最大1.5安培
负载循环 CW(需要空气流100CFM )
焦斑大小（焦斑标称值） 额定33微米
阴极类型 钨灯丝
波纹 1% RMS/均方根 @ 80KVP/250微安
稳定温度 每小时 0.01%/摄氏度
上升时间 从待命时间起250毫秒
尺寸 5.37” 宽, 9.95”长, 5.25”高
重量 7.25千克
绝缘 电气级绝缘油
工作温度 +10 到+35摄氏度
湿度 最大95%
标准 按UL,CUL,VDE, TUV法定标准

Oxford牛津60kV,60W封闭式X光管

发表于由
Oxford牛津60kV,60W封闭式X光管

Oxford牛津60kV,60W封闭式X光管

产品编号：
市场价：￥0.00元
会员价：￥0.00元
品牌：Oxford牛津
生产厂家：Oxford牛津
需求数量：

  • 产品概览
  • 技术参数
  • 订购信息
  • 相关资料
  • 相关产品

Oxford牛津60kV,60W封闭式X光管

XTF6000/BR系列X光管是为需要更高激发电位应用所设计的产品。它可以在60kV,1.0mA下连续工作。 XTF6000/BR非常适宜用在X射线成像和厚度测量应用方面。

 

阳极电流 0到1.5毫安
阳极(靶)电压 4 – 60千伏
最大功率 60瓦连续
灯丝电压 2.0伏 @ 60千伏每毫安
灯丝电流 1.85安培
稳定性 4小时内0.2%
焦斑大小 焦点标称值 80µm*
阴极类型 钨、钼、铑、银、钯+ 可选
出射窗 铍，125 µm（可选75、250）
尺寸 长210.8mm，直径106.2mm
重量 6450克
冷却方式 加压气流 150CFM
最大泄漏 每2英寸0.25mR/hr
锥角 25度