Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Lei Zhang, et al. Characterization of flavonoids in the extract of Sophora flavescens Ait. by high-performance liquid chromatography coupled with diode-array detector and electrospray ionization mass spectrometry. J Pharm Biomed Anal. 2007 Sep 3;44(5):1019-28.
Kushenol L 是苦参乙醇提取物的主要成分之一，苦参是来自 Sophora flavescens Ait 的干燥根。Kushenol L 是一种类黄酮，具有抗糖尿病的作用。
Kushenol L Chemical Structure
CAS No. : 101236-50-4
规格
是否有货
5 mg
询价
10 mg
询价
25 mg
询价
* Please select Quantity before adding items.
生物活性
Kushenol L is one of the main components of EtOA cextracts from Kushen, a traditional medicinal herb derived from the dried roots of Sophora flavescens Ait. Kushenol L is a flavonoid and plays an important role in anti-diabeticeffects[1].
体内研究 (In Vivo)
Kushenol L (1 mg/kg; oral) has a T1/2 of 2.26 hours, a Cmax of 24.17 μg/L and an AUC of 54035 μg/h•L in adult male Sprague-Dawley rats weighing 300 g[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
440.49
Formula
C25H28O7
CAS 号
101236-50-4
中文名称
苦参醇L
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Lei Chen, et al. An accurate and reproducible method for simultaneous determination of four flavonoids in EtOAc extracts from Sophora flavescens Ait. in rat plasma based on UHPLC Q-Exactive Mass spectrometry: Application to a pharmacokinetics study. Biomed Chromatogr. 2019 Mar;33(3):e4447.
Kushenol N 是一种异戊烯基黄酮类化合物，能从 Sophora flavescens 中分离得到。Kushenol N 具有抗过敏和血管舒张作用。
Kushenol N Chemical Structure
CAS No. : 102490-65-3
规格
是否有货
5 mg
询价
10 mg
询价
25 mg
询价
* Please select Quantity before adding items.
生物活性
Kushenol N is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol N has anti-allergic and vasorelaxation activities[1][2].
分子量
454.51
Formula
C26H30O7
CAS 号
102490-65-3
中文名称
苦参醇N
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Wenying Quan, et al. Anti-allergic prenylated flavonoids from the roots of Sophora flavescens. Planta Med. 2008 Feb;74(2):168-70.
[2]. Chul Young Kim, et al. Vasorelaxant prenylated flavonoids from the roots of Sophora flavescens. Biosci Biotechnol Biochem. 2013;77(2):395-7.
Kushenol W 是一种黄酮类化合物，在 Sophora flavescens 发现。Kushenol W 具有抗菌作用，对金黄色葡萄球菌的 MIC 为 10 μg/mL。
Kushenol W Chemical Structure
CAS No. : 254886-76-5
规格
是否有货
5 mg
询价
10 mg
询价
25 mg
询价
* Please select Quantity before adding items.
生物活性
Kushenol W is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol W has antimicrobial effect, with a MIC of 10 μg/mL for Staphylococcus aureus[1].
分子量
386.40
Formula
C21H22O7
CAS 号
254886-76-5
中文名称
苦参醇W
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Motahare Boozari, et al. Biologically active prenylated flavonoids from the genus Sophora and their structure-activity relationship-A review. Phytother Res. 2019 Mar;33(3):546-560.
Kushenol B 是一种从 S. flavescens 中分离得到的异戊二烯类黄酮，具有抗菌、抗炎和抗氧化活性。Kushenol B 对 cAMP 磷酸二酯酶 (cAMP PDE) 有抑制活性，IC50 为 31 µM。
Kushenol B Chemical Structure
CAS No. : 99217-64-8
规格
是否有货
5 mg
询价
10 mg
询价
25 mg
询价
* Please select Quantity before adding items.
生物活性
Kushenol B is an isoprenoid flavonoid isolated from S. flavescens, has antimicrobial, anti-inflammatory and antioxidant activities[1]. Kushenol B has inhibitory activity against cAMP phosphodiesterase (PDE), with an IC50 of 31 µM[1].
IC50 & Target
IC50: 31 µM (cAMP PDE)[1]
分子量
492.60
Formula
C30H36O6
CAS 号
99217-64-8
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Han-Tian Fan, et al. The rational search for PDE10A inhibitors from Sophora flavescens roots using pharmacophore‑ and docking‑based virtual screening. Mol Med Rep
Kushenol M 是一种黄酮类化合物，在 Sophora flavescens 发现。 Kushenol M 是一种细胞色素 P450 (CYP) 抑制剂，对人肝微粒体中 CYP3A4 抑制作用的 IC50 值为 1.29 μM。
Kushenol M Chemical Structure
CAS No. : 101236-51-5
规格
是否有货
5 mg
询价
10 mg
询价
25 mg
询价
* Please select Quantity before adding items.
生物活性
Kushenol M is a flavonoid from Sophora flavescens. Kushenol M is a cytochrome P450 (CYP) inhibitor, with IC50 values of 1.29 μM for CYP3A4 in human liver microsomes[1].
分子量
508.60
Formula
C30H36O7
CAS 号
101236-51-5
中文名称
苦参醇M
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Xinguang Liu, et al. Advances in Metabolic Profiling and Pharmacokinetics of Herbal Medicinal Products. Evid Based Complement Alternat Med. 2019 May 6;2019:5190972.
Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and human carboxylesterase 2 (hCE2) inhibitor with IC50s of 2.07 μM and 3.05 μM, respectively[1][2].
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Cheng-Peng Sun, et al. The study of inhibitory effect of natural flavonoids toward β-glucuronidase and interaction of flavonoids with β-glucuronidase. Int J Biol Macromol. 2020 Jan 15;143:349-358.
[2]. Sha-Sha Song, et al. Flavonoids as human carboxylesterase 2 inhibitors: Inhibition potentials and molecular docking simulations. Int J Biol Macromol. 2019 Jun 15;131:201-208.
Kushenol K，一种从 Sophora flavescens 中提取的黄酮类抗氧化剂。Kushenol K 是 CYP3A4 的抑制剂，Ki 值为 1.35 μM。Kushenol K 对 HSV-2 具有较弱的抗病毒活性 (EC50 为 147 μM)。Kushenol K 还抑制 SGLT1 和 SGLT2 的活性。
Kushenol K Chemical Structure
CAS No. : 101236-49-1
规格
是否有货
5 mg
询价
10 mg
询价
25 mg
询价
* Please select Quantity before adding items.
生物活性
Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM)[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3].
IC50 & Target[1][2][3]
HSV-2
147 μM (EC50)
CYP3A4
1.35 μM (Ki)
SGLT
体外研究 (In Vitro)
When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC50 values of 1.62 µM[1]. At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%[3].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
472.53
Formula
C26H32O8
CAS 号
101236-49-1
中文名称
苦参醇K；苦参醇 K
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Yannan Li, et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.
[2]. E R Woo, et al. A new prenylated flavonol from the roots of Sophora flavescens. J Nat Prod. 1998 Dec;61(12):1552-4.
[3]. Seizo Sato, et al. Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9.
Sophoraflavanone G (Kushenol F) 是从苦参中提取得到的，具有抗肿瘤和抗炎特性。Sophoraflavanone G (Kushenol F) 通过抑制 MAPK 相关途径诱导 MDA-MB-231 和 HL-60 细胞凋亡 (apoptosis)。
Sophoraflavanone G Chemical Structure
CAS No. : 97938-30-2
规格
价格
是否有货
数量
5 mg
￥1190
In-stock
10 mg
￥2020
In-stock
20 mg
￥3430
In-stock
50 mg
询价
100 mg
询价
* Please select Quantity before adding items.
Sophoraflavanone G 相关产品
•相关化合物库:
Natural Product Library Plus
Bioactive Compound Library Plus
Apoptosis Compound Library
Natural Product Library
Anti-Cancer Compound Library
Phenols Library
Traditional Chinese Medicine Monomer Library
Flavonoids Library
生物活性
Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties. Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways[1][2].
IC50 & Target
IC50: 29.7 μM (MDA-MB-231 cell)[1]
体外研究 (In Vitro)
Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells in a dose-dependent manner[1]. Sophoraflavanone G (0 -100 μM; 24 hours) induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated “intrinsic” pathway[1] Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner, with an IC50 value of 29.7 ± 5.2 μM[2]<.br>
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
424.49
Formula
C25H28O6
CAS 号
97938-30-2
中文名称
苦参总黄酮； 苦参酚 F
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Li ZY, et al. Sophoraflavanone G Induces Apoptosis in Human Leukemia Cells and Blocks MAPK Activation.Am J Chin Med. 2016;44(1):165-76.
[2]. Huang WC, et al. Sophoraflavanone G from Sophora flavescens induces apoptosis in triple-negative breast cancer cells.Phytomedicine. 2019 Aug;61:152852.
Kushenol C 是从苦参根中分离出来的，具有抗炎和抗氧化的作用。Kushenol C 抑制 BACE1 的 IC50 值为 5.45 µM。
Kushenol C Chemical Structure
CAS No. : 99119-73-0
规格
是否有货
5 mg
询价
10 mg
询价
25 mg
询价
* Please select Quantity before adding items.
生物活性
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 µM[1][2].
体外研究 (In Vitro)
Kushenol C dose-dependently suppresses the production of inflammatory mediators, including NO, PGE2, IL-6, IL1β, MCP-1, and IFN-β in LPS-stimulated RAW264.7 macrophages. Kushenol C (50-100 µM;) significantly decreases the phosphorylation of both STAT1 molecules and STAT6 in a dose-dependent manner in LPS-stimulated RAW264.7 cells[1]. Kushenol C upregulates the expression of HO-1 and its activities in the LPS-stimulated RAW264.7 macrophages. In HaCaT cells, Kushenol C prevents DNA damage and cell death by upregulating the endogenous antioxidant defense system involving glutathione, superoxide dismutase, and catalase, which prevents reactive oxygen species production from tert-butyl hydroperoxide (tBHP)-induced oxidative stress in HaCaT cells[1]. Kushenol C inhibits BChE and AChE with IC50s of 54.86 and 33.13 µM[2].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
438.47
Formula
C25H26O7
CAS 号
99119-73-0
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Cho BO, et al. In vitro Anti-Inflammatory and Anti-Oxidative Stress Activities of Kushenol C Isolated from the Roots of Sophoraflavescens. Molecules. 2020;25(8):1768. Published 2020 Apr 12.
[2]. Jung HA, et al. Selective inhibition of prenylated flavonoids from Sophora flavescens against BACE1 and cholinesterases. Am J Chin Med. 2010;38(2):415-429.
