JKC363 TFA

JKC363 TFA;

JKC363 TFA 是一种选择性黑素皮质激素 MC4 受体拮抗剂，在 MC4 受体 (IC₅₀=0.5 nM) 的亲和力比 MC3 受体 (44.9 nM) 高 90 倍。JKC363 TFA 阻断 α-MSH 对 TRH 释放的刺激作用。具有抗痛觉作用。

JKC363 TFA Chemical Structure

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生物活性	JKC363 TFA, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC₅₀=0.5 nM) than at the MC3 receptor (44.9 nM). JKC363 TFA blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect^[1]^[2].
分子量	1620.73
Formula	C₇₁H₉₃F₃N₁₉O₁₈S₂
Sequence Shortening	{Mpa}-EH-{D-2-Nal}-RWGCPPKD (Disulfide bridge:Mpa1-Cys8)
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Kim MS, et al. Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: evidence for the differential roles of melanocortin 3 and 4 receptors. J Neuroendocrinol. 2002;14(4):276-282. [2]. Bellasio S, et al. Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur J Pharmacol. 2003;482(1-3):127-132.

JKC363

JKC363;

JKC363 是一种选择性黑素皮质激素 MC4 受体拮抗剂，在 MC4 受体 (IC₅₀=0.5 nM) 的亲和力比 MC3 受体 (44.9 nM) 高90倍。JKC363 阻断 α-MSH 对 TRH 释放的刺激作用。具有抗痛觉作用。

JKC363 Chemical Structure

CAS No. : 436083-30-6

* Please select Quantity before adding items.

生物活性	JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC₅₀=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect^[1]^[2].
分子量	1506.71
Formula	C₆₉H₉₁N₁₉O₁₆S₂
CAS 号	436083-30-6
Sequence Shortening	{Mpa}-EH-{D-2-Nal}-RWGCPPKD (Disulfide bridge:Mpa1-Cys8)
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Kim MS, et al. Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: evidence for the differential roles of melanocortin 3 and 4 receptors. J Neuroendocrinol. 2002;14(4):276-282. [2]. Bellasio S, et al. Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur J Pharmacol. 2003;482(1-3):127-132.