标签归档：intermediate

FR179642

发表于由

FR179642;

FR179642 是抗真菌试剂 Micafungin 在合成过程中一个关键的中间体 (intermediate)。FR179642 也是抗真菌脂肽 FR901379 的环肽核。

FR179642amp;;

FR179642 Chemical Structure

CAS No. : 168110-44-9

规格 价格 是否有货
50 mg ￥800 询问价格 货期
100 mg ￥1300 询问价格 货期

* Please select Quantity before adding items.

生物活性

FR179642 is a key intermediate in the synthesis of the echinocandin antifungal Micafungin[1]. FR179642 is the cyclic peptide nucleus of the echinocandin-like antifungal lipopeptide FR901379[2].

分子量

936.89

Formula

C35H52N8O20S
CAS 号

168110-44-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Satoshi Ueda, et al. Cloning and expression of the FR901379 acylase gene from Streptomyces sp. no. 6907. J Antibiot (Tokyo)

    [2]. M Tomishima, et al. FK463, a novel water-soluble echinocandin lipopeptide: synthesis and antifungal activity. J Antibiot (Tokyo)

Alisporivir intermediate-1

发表于由

Alisporivir intermediate-1;

Alisporivir intermediate-1 是合成 Alisporivir 的中间体。Alisporivir 可用于研究炎症和病毒性疾病。

Alisporivir intermediate-1amp;;

Alisporivir intermediate-1 Chemical Structure

CAS No. : 882506-05-0

规格 价格 是否有货
1 mg ￥1900 询问价格 货期
5 mg ￥5900 询问价格 货期

* Please select Quantity before adding items.

生物活性

Alisporivir intermediate-1 is an intermediate in the synthesis of Alisporivir. Alisporivir is used for the treatment of inflammatory and viral diseases.

分子量

1461.91

Formula

C74H132N12O17
CAS 号

882506-05-0
Sequence Shortening

{d-Ala}-VVLA-{d-Ala}-LLV-{Aaa}-{Abu}
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Werkmeister S, et al. Hydrogenation of esters to alcohols with a well-defined iron complex. Angew Chem Int Ed Engl. 2014 Aug 11;53(33):8722-6.