标签归档：inhibitory

IKKγ NBD Inhibitory Peptide

发表于由

IKKγ NBD Inhibitory Peptide;

IKKγ NBD Inhibitory Peptide是 NEMO 结合域的多肽，对应着 NEMO 氨基端α螺旋区，可以阻断 TNFα 诱导的 NF-kB 激活。

IKKγ NBD Inhibitory Peptideamp;;

IKKγ NBD Inhibitory Peptide Chemical Structure

CAS No. : 372146-18-4

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

IKKgamma; NBD Inhibitory Peptide 的其他形式现货产品:

IKKgamma; NBD Inhibitory Peptide TFA

生物活性

IKKγ NBD Inhibitory Peptide is a NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region, which is shown to block TNF-alpha-induced NF-kB activation[1].

分子量

3693.30

Formula

C170H259N49O42S1
CAS 号

372146-18-4
Sequence Shortening

DRQIKIWFQNRRMKWKKTALDWSWLQTE
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Zhao J, et al. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation. PLoS Biol. 2018 Jun 11;16(6):e2004663.

DynaMin inhibitory peptide, myristoylated TFA

发表于由

DynaMin inhibitory peptide, myristoylated TFA;

DynaMin inhibitory peptide, myristoylated TFA 是一种 DynaMin 抑制剂，可干扰两性霉素 (amphiphysin) 与动力蛋白 (dynamin) 的结合。DynaMin inhibitory peptide, myristoylated TFA 是肽的膜渗透形式，可防止细胞内吞。

DynaMin inhibitory peptide, myristoylated TFAamp;;

DynaMin inhibitory peptide, myristoylated TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

DynaMin inhibitory peptide, myristoylated TFA is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated TFA is a membrane-permeant form of the peptide that prevents endocytosis[1].

分子量

1444.64

Formula

C63H108F3N19O16
Sequence Shortening

Myristoyl-QVPSRPNRAP-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Yi Nong, et al. Glycine binding primes NMDA receptor internalization. Nature. 2003 Mar 20;422(6929):302-7.

    [2]. Sónia Troeira Henriques, et al.The Prototypic Cyclotide Kalata B1 Has a Unique Mechanism of Entering Cells. Chem Biol. 2015 Aug 20;22(8):1087-97.

Autocamtide-2-related inhibitory peptide

发表于由

Autocamtide-2-related inhibitory peptide;

Autocamtide-2-related inhibitory peptide 是高度特异性的、CaMKII 的有效抑制剂，其IC50 值为 40 nM。

Autocamtide-2-related inhibitory peptideamp;;

Autocamtide-2-related inhibitory peptide Chemical Structure

CAS No. : 167114-91-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Autocamtide-2-related inhibitory peptide 的其他形式现货产品:

Autocamtide-2-related inhibitory peptide TFA

生物活性

Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.

IC50 Target

IC50: 40 nM (CaMKII)[1].
体外研究
(In Vitro)

It is found that Autocamtide-2-related inhibitory peptide (a novel synthetic peptide ATP) is a potent inhibitor of CaM-kinase II with an IC50 of 40 nM, which is active in the presence or absence of Ca2+/calmodulin. It is 50 and 500 times more potent than CaMK-(281-302Ala286) and KN-93,respectively, under the assay condition used[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1497.74

Formula

C64H116N22O19
CAS 号

167114-91-2
Sequence

Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu
Sequence Shortening

KKALRRQEAVDAL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12.

Autocamtide-2-related inhibitory peptide, myristoylated

发表于由

Autocamtide-2-related inhibitory peptide, myristoylated;

Autocamtide-2-related inhibitory peptide, myristoylated 是Autocamtide-2-related inhibitory peptide 烷基化修饰后的形式。 Autocamtide-2-related inhibitory peptide 是高度特异性的、CaMKII 的有效抑制剂，其IC50 值为 40 nM。

Autocamtide-2-related inhibitory peptide, myristoylatedamp;;

Autocamtide-2-related inhibitory peptide, myristoylated Chemical Structure

CAS No. : 201422-04-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Autocamtide-2-related inhibitory peptide, myristoylated is the myristoylated Autocamtide-2-related inhibitory peptide. Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM[1].

分子量

1708.10

Formula

C78H142N22O20
CAS 号

201422-04-0
Sequence

{Lys(Myr)}-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu
Sequence Shortening

{Lys(Myr)}-KALRRQEAVDAL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12.

Dynamin inhibitory peptide TFA

发表于由

Dynamin inhibitory peptide TFA;

Dynamin inhibitory peptide TFA 竞争性地阻止了动力蛋白 (dynamin) 与两性纤维蛋白的结合，从而防止了内吞作用。Dynamin inhibitory peptide TFA 阻断多巴胺 D3 对 GABAA 受体的作用。

Dynamin inhibitory peptide TFAamp;;

Dynamin inhibitory peptide TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Dynamin inhibitory peptide TFA competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide TFA blocks the dopamine D3 effect on GABAA receptors[1].

体外研究
(In Vitro)

Dynamin inhibitory peptide TFA (50 μM) inhibits GABAAR endocytosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1235.27

Formula

C49H81F3N18O16
Sequence

Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro
Sequence Shortening

QVPSRPNRAP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Guojun Chen, et al. Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. J Neurosci. 2006 Mar 1;26(9):2513-21.

DynaMin inhibitory peptide, myristoylated

发表于由

DynaMin inhibitory peptide, myristoylated;

DynaMin inhibitory peptide, myristoylated 是一种 DynaMin 抑制剂，可干扰两性霉素 (amphiphysin) 与动力蛋白 (dynamin) 的结合。DynaMin inhibitory peptide, myristoylated 是肽的膜渗透形式，可防止细胞内吞。

DynaMin inhibitory peptide, myristoylatedamp;;

DynaMin inhibitory peptide, myristoylated Chemical Structure

CAS No. : 251634-22-7

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

DynaMin inhibitory peptide, myristoylated is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated is a membrane-permeant form of the peptide that prevents endocytosis[1].

分子量

1330.62

Formula

C61H107N19O14
CAS 号

251634-22-7
Sequence Shortening

Myristoyl-QVPSRPNRAP-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Yi Nong, et al. Glycine binding primes NMDA receptor internalization. Nature. 2003 Mar 20;422(6929):302-7.

    [2]. Sónia Troeira Henriques, et al.The Prototypic Cyclotide Kalata B1 Has a Unique Mechanism of Entering Cells. Chem Biol. 2015 Aug 20;22(8):1087-97.

Ras Inhibitory Peptide 品牌：FUJIFILM Wako

发表于由

Ras Inhibitory Peptide

品牌：FUJIFILM Wako
CAS No.：159088-48-9
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

182-01731

 for Biochemistry 1 mg –

Ras Inhibitory Peptide 品牌：FUJIFILM Wako

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Autocamtide-2-related inhibitory peptide, myristoylated TFA

发表于由

Autocamtide-2-related inhibitory peptide, myristoylated TFA;

Autocamtide-2-related inhibitory peptide, myristoylated TFA 是Autocamtide-2-related inhibitory peptide 烷基化修饰后的形式。 Autocamtide-2-related inhibitory peptide 是高度特异性的、CaMKII 的有效抑制剂，其IC50 值为 40 nM。

Autocamtide-2-related inhibitory peptide, myristoylated TFAamp;;

Autocamtide-2-related inhibitory peptide, myristoylated TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Autocamtide-2-related inhibitory peptide, myristoylated TFA is the myristoylated Autocamtide-2-related inhibitory peptide. Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM[1].

分子量

1822.12

Formula

C78H142N22O20.C2HF3O2
Sequence

{Lys(Myr)}-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu
Sequence Shortening

{Lys(Myr)}-KALRRQEAVDAL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12.

Dynamin inhibitory peptide

发表于由

Dynamin inhibitory peptide;

Dynamin inhibitory peptide 竞争性地阻止了动力蛋白 (dynamin) 与两性纤维蛋白的结合，从而防止了内吞作用。Dynamin inhibitory peptide 阻断多巴胺 D3 对 GABAA 受体的作用。

Dynamin inhibitory peptideamp;;

Dynamin inhibitory peptide Chemical Structure

CAS No. : 251634-21-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide blocks the dopamine D3 effect on GABAA receptors[1].

体外研究
(In Vitro)

Dynamin inhibitory peptide (50 μM) inhibits GABAAR endocytosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1121.25

Formula

C47H80N18O14
CAS 号

251634-21-6
Sequence

Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro
Sequence Shortening

QVPSRPNRAP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Guojun Chen, et al. Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. J Neurosci. 2006 Mar 1;26(9):2513-21.

Autocamtide-2-related inhibitory peptide TFA

发表于由

Autocamtide-2-related inhibitory peptide TFA  纯度: 95.85%

Autocamtide-2-related inhibitory peptide (TFA) 是高度特异性的、CaMKII 的有效抑制剂，其 IC50 值为 40 nM。

Autocamtide-2-related inhibitory peptide TFA 

Autocamtide-2-related inhibitory peptide TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥2200 In-stock
5 mg ￥8900 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Autocamtide-2-related inhibitory peptide TFA 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Autocamtide-2-related inhibitory peptide (TFA) is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.

IC50 & Target

IC50: 40 nM (CaMKII)[1].
体外研究
(In Vitro)

It is found that Autocamtide-2-related inhibitory peptide (TFA) is a potent inhibitor of CaM-kinase II with an IC50 of 40 nM, which is active in the presence or absence of Ca2+/calmodulin. It is 50 and 500 times more potent than CaMK-(281-302Ala286) and KN-93, respectively, under the assay condition used[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1611.76

Formula

C66H126N22O21F3
Sequence

Lys-Lys-Ala-Lru-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu
Sequence Shortening

KKALRRQEAVDAL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : 110 mg/mL (68.25 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6204 mL 3.1022 mL 6.2044 mL
5 mM 0.1241 mL 0.6204 mL 1.2409 mL
10 mM 0.0620 mL 0.3102 mL 0.6204 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12.

  • [1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12.