标签归档：iia

anti-Myosin IIA (non-muscle) (heavy chain), mAb (rec.) (SF9) (ATTO 488) 肌球蛋白IIA（非肌肉）（重链）单抗（重组）（SF9） （ATTO 488） 品牌：Adipogen

发表于由

anti-Myosin IIA (non-muscle) (heavy chain), mAb (rec.) (SF9) (ATTO 488)

肌球蛋白IIA（非肌肉）（重链）单抗（重组）（SF9） （ATTO 488）

品牌：Adipogen
CAS No.：
储存条件：+4°C
纯度：>95% (SDS-PAGE)
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

AG-27B-0010TD-C100

 – 100 µg – 4,200.00 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Tanshinone IIA(Synonyms: Dan Shen ketone)

发表于由

天然产物醌类Quinones

Tanshinone IIA (Synonyms: Dan Shen ketone) 纯度: 99.74%

Tanshinone IIA (Tan IIA) 是红根丹参根系中的主要组合物之一。Tanshinone IIA 可以通过靶向 VEGF/VEGFR2 的蛋白激酶结构域来抑制血管生成。

Tanshinone IIA(Synonyms: Dan Shen ketone)

Tanshinone IIA Chemical Structure

CAS No. : 568-72-9

规格 价格 是否有货 数量
10 mg ￥600 In-stock
25 mg ￥1200 In-stock
50 mg ￥2100 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Tanshinone IIA 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus

生物活性

Tanshinone IIA (Tan IIA) is one of the main compositions in the root of red-rooted salvia. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.

IC50 & Target

VEGF/VEGFR2[1]
体外研究
(In Vitro)

The anti-tumor effect of Tanshinone IIA includes inhibiting tumor cell proliferation, disturbing tumor cell cycle, promoting tumor cell apoptosis, and inhibiting tumor cell invasion and transfer. Tanshinone IIA has anti-proliferative effects on A549 cells: the IC50 of Tanshinone IIA after 24, 48 and 72 h are 145.3, 30.95 and 11.49 μM, respectively. The CCK-8 assay is used to evaluate the proliferative activity of A549 cells treated with Tanshinone IIA (2.5-80 μM) for 24, 48 and 72 h, respectively. The CCK-8 results show that Tanshinone IIA can significantly inhibit A549 cell proliferation in a dose- and time-dependent manner. Obvious apoptosis and cell growth inhibition of A549 cells are observed after drug treatment for 48 h (concentrations used are approximately IC50 values: Tanshinone IIA 31 μM on A549). Western blotting finds that 48 h exposures to Tanshinone IIA (31 μM) in A549 cells, downregulates expression of VEGF and VEGFR2 protein in both drug treatment groups vs. vehicle[1]. Tanshinone IIA, one of the most abundant constituents of the root of Salvia miltiorrhiza, protects rat myocardium-derived H9C2 cells against apoptosis. Treatment of H9C2 cells with Tanshinone IIA inhibits angiotensin II-induced apoptosis by downregulating the expression of PTEN (phosphatase and tensin homolog), a tumor suppressor that plays a critical role in apoptosis. Tanshinone IIA inhibits angiotensin II (AngII)-induced apoptosis by downregulating the expression of phosphatase and tensin homolog (PTEN)[2]. Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Tanshinone IIA (10 or 20 mg/kg; p.o) significantly reverses scopolamine-induced cognitive impairments[4].
Tanshinone IIA (2, 4, 8 mg/kg; i.p.) mediated protective effects on the STZ-induced diabetic nephropathy may be associates with the reduced endoplasmic reticulum stress via attenuating PERK signaling activities[5].
Tanshinone IIA (3 and 12 mg/kg; i.p.) significantly inhibits the growth of ectopic endometrium[6].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (25–30 g)[4]
Dosage: 10 or 20 mg/kg
Administration: P.o.
Result: Significantly reversed scopolamine-induced cognitive impairments.
Animal Model: STZ-treated rats[5]
Dosage: 2, 4, 8 mg/kg
Administration: I.p.
Result: Decreased the expression levels of transforming growth factor-beta1, TSP-1, Grp78 and CHOP and attenuated the increase in the protein levels of p-PERK, p-elf2α and ATF-4 from the renal tissues of diabetic rats.
Animal Model: Female Sprague-Dawley rats (180 -200g)[6]
Dosage: 3 and 12 mg/kg
Administration: I.p.
Result: Significantly inhibited the growth of ectopic endometrium.

分子量

294.34

Formula

C19H18O3
CAS 号

568-72-9
中文名称

丹参酮 IIA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (339.74 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3974 mL 16.9872 mL 33.9743 mL
5 mM 0.6795 mL 3.3974 mL 6.7949 mL
10 mM 0.3397 mL 1.6987 mL 3.3974 mL

*

请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.49 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.49 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Xie J, et al. The antitumor effect of tanshinone IIA on anti-proliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line. Acta Pharm Sin B. 2015 Nov;5(6):554-63.

    [2]. Zhang Z, et al. Tanshinone IIA inhibits apoptosis in the myocardium by inducing microRNA-152-3p expression and thereby downregulating PTEN. Am J Transl Res. 2016 Jul 15;8(7):3124-32.

    [3]. Su CC, et al. Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo. Oncol Rep. 2016 Aug;36(2):1173-9.

Tanshinone IIA sulfonate sodium(Synonyms: 丹参酮IIA磺酸盐; Sodium Tanshinone IIA sulfonate; Tanshinone IIA sodium sulfonate)

发表于由

天然产物醌类Quinones

Tanshinone IIA sulfonate sodium (Synonyms: 丹参酮IIA磺酸盐; Sodium Tanshinone IIA sulfonate; Tanshinone IIA sodium sulfonate) 纯度: ≥98.0%

Tanshinone IIA sulfonate sodium 是 tanshinone IIA 的衍生物，为 SOCE 的抑制剂，用于心血管疾病的研究。

Tanshinone IIA sulfonate sodium(Synonyms: 丹参酮IIA磺酸盐; Sodium Tanshinone IIA sulfonate; Tanshinone IIA sodium sulfonate)

Tanshinone IIA sulfonate sodium Chemical Structure

CAS No. : 69659-80-9

规格 价格 是否有货 数量
10 mg ￥500 In-stock
25 mg ￥1100 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Tanshinone IIA sulfonate sodium 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • Bioactive Compound Library Plus

生物活性

Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+ entry (SOCE), and is used to treat cardiovascular disorders.

体外研究
(In Vitro)

Sodium Tanshinone IIA sulfonate (12.5 μM) inhibits hypoxia-induced PKG and PPAR-γ downregulation in PASMCs and distal pulmonary arteries of rats. The suppressive effects of Sodium Tanshinone IIA sulfonate on TRPC1 and TRPC6 expression in hypoxic PASMCs can be prevented by specific knockdown PKG or PPAR-γ. The suppressive effects of Sodium Tanshinone IIA sulfonate on basal calcium concentration and SOCE in hypoxic PASMCs can be reversed by specific knockdown of PKG or PPAR-γ. PKG-PPAR-γ signaling axis participates in the suppressive effects of Sodium Tanshinone IIA sulfonate on proliferation in hypoxic PASMCs. PPAR-γ agonist promotes the protective role of Sodium Tanshinone IIA sulfonate on basal [Ca2+]i and SOCE in hypoxic PASMCs[2]. Sodium tanshinone IIA sulfonate inhibits the activity of CYP3A4 in a dose-dependent manner by the HLMs and CYP3A4 isoform. The KM and Vmax values of STS are 54.8±14.6 µM and 0.9±0.1 nmol/mg protein/min, respectively, for the HLMs and 7.5±1.4 µM and 6.8±0.3 nmol/nmol P450/min, respectively, for CYP3A4. CYP1A2, CYP2A6, CYP2C9, CYP2D6, CYP2E1, and CYP2C19 show minimal or no effects on the metabolism of STS[3]. Sodium Tanshinone IIA sulfonate inhibits the activity of CYP3A4 in a dose-dependent manner in the HLMs and CYP3A4 isoform. Sodium Tanshinone IIA sulfonate primarily inhibits the activities of CYP3A4 in vitro, and Sodium Tanshinone IIA sulfonate has the potential to perpetrate drug-drug interactions with other CYP3A4 substrates[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Sodium Tanshinone IIA sulfonate (10 mg/kg, 20 mg/kg) and Donepezil shorten escape latency, increase crossing times of the original position of the platform, and increase the time spent in the target quadrant. Sodium Tanshinone IIA sulfonate decreases the activity of acetylcholinesterase (AChE) and increases the activity of choline acetyltransferase (ChAT) in the hippocampus and cortex of SCOP-treated mice. Sodium Tanshinone IIA sulfonate increases the activity of superoxide dismutase (SOD) and decreases the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in hippocampus and cortex[1]. Sodium Tanshinone IIA sulfonate prevention (30 mg/kg/day) alleviates hypoxia-induced characteristic changes in chronic hypoxia PH rat model[2]. Sodium Tanshinone IIA sulfonate (20, 10, and 5 mg/kg, i.p.) effectively prevents peritoneal adhesion without affecting anastomotic healing in the rats. Compared with the adhesion model group, the Sodium Tanshinone IIA sulfonate-treated groups show increased peritoneal lavage fluid tPA activity and tPA/PAI-1 ratio in the ischemic tissues with loared TGF-β1 and collagen I expressions in the ischemic tissues[5].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

396.39

Formula

C19H17NaO6S
CAS 号

69659-80-9
中文名称

丹参酮IIA磺酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。
溶解性数据
In Vitro: 

DMSO : 62.5 mg/mL (157.67 mM; Need ultrasonic)

H2O : 8.33 mg/mL (21.01 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5228 mL 12.6138 mL 25.2277 mL
5 mM 0.5046 mL 2.5228 mL 5.0455 mL
10 mM 0.2523 mL 1.2614 mL 2.5228 mL

*

请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.25 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (5.25 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: 2.08 mg/mL (5.25 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.08 mg/mL (5.25 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Xu QQ, et al. Sodium Tanshinone IIA Sulfonate Attenuates Scopolamine-Induced Cognitive Dysfunctions via Improving Cholinergic System. Biomed Res Int. 2016;2016:9852536

    [2]. Jiang Q, et al. Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis. Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C136-49.

    [3]. Ouyang DS, et al. Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone IIA sulfonate in vitro. Chin Med. 2016 Mar 22;11:11.

    [4]. Chen D, et al. Sodium tanshinone IIA sulfonate and its interactions with human CYP450s. Xenobiotica. 2016 Dec;46(12):1085-1092. Epub 2016 Mar 2.

    [5]. Lin S, et al. [Sodium tanshinone IIA sulfonate prevents postoperative peritoneal adhesions in rats by enhancing the activity of the peritoneal fibrinolytic system]. Nan Fang Yi Ke Da Xue Xue Bao. 2016 Feb;36(2):260-4.
Animal Administration
[1][2]

Mice[1]
Male Kunming mice (KM, weighing 35-40 g) are maintained on standard laboratory conditions with free access to water and food. Mice are randomly divided into five groups: vehicle control group (CON, 0.9% saline, n=10), scopolamine group (SCOP, n=10), low dose Sodium Tanshinone IIA sulfonate group (Sodium Tanshinone IIA sulfonate L, SCOP 3 mg/kg + Sodium Tanshinone IIA sulfonate 10 mg/kg, n=10), high dose Sodium Tanshinone IIA sulfonate group (Sodium Tanshinone IIA sulfonate H, SCOP 3 mg/kg + Sodium Tanshinone IIA sulfonate 20 mg/kg, n=10), and Donepezil group (DON, SCOP 3 mg/kg + ARI 3 mg/kg, n=10). Mice are treated with saline, Sodium Tanshinone IIA sulfonate, and Donepezil, respectively, by gavage, once per day for two weeks. SCOP is injected from the eighth day for one week (intraperitoneally, IP). The SCOP is injected 0.5 h before the Morris water maze test.
Rats[2]
Male Sprague-Dawley rats (200-250 g) are randomly divided into four groups by the random number table: 1) normoxia control group, 2) normoxia + Sodium Tanshinone IIA sulfonate group, 3) hypoxia control group, and 4) hypoxia + Sodium Tanshinone IIA sulfonate group. Groups 1 and 2 are placed in normoxic condition and groups 3 and 4 in a hypoxic cabin with normal pressure, as previously reported, where the oxygen concentration is maintained at 10±1%, in a sustained hypoxic condition for 21 days. Groups 2 and 4, starting from the first day of hypoxia, are, respectively, intraperitoneally injected with 30 mg/kg tanshinone IIA sulfonate; meanwhile, groups 1 and 3 receive the same dose of saline.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Xu QQ, et al. Sodium Tanshinone IIA Sulfonate Attenuates Scopolamine-Induced Cognitive Dysfunctions via Improving Cholinergic System. Biomed Res Int. 2016;2016:9852536

    [2]. Jiang Q, et al. Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis. Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C136-49.

    [3]. Ouyang DS, et al. Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone IIA sulfonate in vitro. Chin Med. 2016 Mar 22;11:11.

    [4]. Chen D, et al. Sodium tanshinone IIA sulfonate and its interactions with human CYP450s. Xenobiotica. 2016 Dec;46(12):1085-1092. Epub 2016 Mar 2.

    [5]. Lin S, et al. [Sodium tanshinone IIA sulfonate prevents postoperative peritoneal adhesions in rats by enhancing the activity of the peritoneal fibrinolytic system]. Nan Fang Yi Ke Da Xue Xue Bao. 2016 Feb;36(2):260-4.

海尔生物安全柜半排HR30-IIA2

发表于由

海尔生物安全柜半排HR30-IIA2

产品型号： HR30-IIA2 品  牌： 海尔
智能控制 安全可靠
产品用途

适用于微生物学，生物医学，生物安全实验室和其他实验室的生物安全防护隔离设备。
采用先进的空气净化技术和负压箱体设计，实现对环境、人员和样品的保护，可以防止有害悬浮微粒、气溶胶的扩散；对操作人员、样品及样品间交叉感染和环境提供安全保护。
功能特点
产品优势
操作省心:所有异常状态全部设置了报警提示，对误操作均设置连锁保护，即使没有经过严格培训，也不会造成伤害。此项设计被鉴定为国际水平，并被授予国家（号：ZL 2005 2 0125227.5）
使用安心： 运行状态全部显示,一目了然获知风机、过滤器、紫外灯、气流等各项运行指标。
完美的结构
符合人体工程学原理的10°倾斜角设计，操作感受更佳；
工作区三侧壁板采用不锈钢一体化结构，12mm大圆弧过渡避免清洁死角；
柜体和支架可分离，多种支架备选；
配备国际流行的搁手支架，使操作者更安全、更舒适；
配备安全防溅插座和实验水气嘴。
可靠的防护
技术的前窗玻璃平衡器悬挂系统设计，门体升降自如；
6mm厚度防紫外线钢化玻璃前窗，提供安全有效的保护；
创新的气流隔断技术，杜绝了前窗上沿和两侧的泄漏（号：ZL 2005 2 0125549.X）；
全漏电保护设计，可有效保护操作者的安全；
严格的气密性检测，加压500Pa，保持30min后气压不低于450Pa。
安全报警设计
门限位报警——开门高度超过安全高度报警，防止实验微生物泄漏；
气流波动报警——气流波动超过20%报警，保证气幕可靠；
关风机门未关严报警——防止实验微生物泄漏；
参数表
型号 过滤效率 洁净等级 送风风速 吸入口风速
HR30-ⅡA2 99.9995%@0.12um 十级 0.31m/s 0.55m/s
HR40-ⅡA2 0.28m/s 0.55m/s
HR40-ⅡB2 0.28m/s 0.55m/s
HR50-ⅡA2 0.28m/s 0.55m/s

 

型号 外形尺寸(宽*深*高mm) 操作区尺寸 (宽*深*高mm) 照度 噪音(db) 建议适用人数
HR30-ⅡA2 1100×790×2200 900×610×680 ≥1100Lx ≤61 1
HR40-ⅡA2 1360×790×2200 1167×610×680 ≥1000Lx ≤65 1-2
HR40-ⅡB2 1360×790×2330 1167×610×680 ≥900Lx ≤62 1-2
HR50-ⅡA2 1780×790×2200 1585×610×680 ≥1200Lx ≤66 1-2

本公司是海尔科研仪器设备上海区的总代理商，垂询！我们将保证提供地区*具竞争力的价格和*优质的售前、售中、售后服务!

海尔A2型生物安全柜HR60-IIA2

发表于由

海尔A2型生物安全柜HR60-IIA2

产品型号： HR60-IIA2 品  牌： 海尔

■ 海尔生物安全柜HR60-IIA2让您享受工作的乐趣
·操作省心：所有异常状态全部设置了报警提示，对误操作均设置连锁保护，即使没有经过培训，也不会造成伤害。此项设计被鉴定为国际领先水平，并被授予国家专利（专利号：ZL200520125227.5）
·使用安心：运行状态全部显示,一目了然获知风机、过滤器、紫外灯、气流等各项运行指标
■ 完美的结构
·符合人体工程学原理的10°倾斜角设计，操作感受更佳
·工作区三侧壁板采用不锈钢一体化结构，12mm大圆弧过渡避免清洁死角
·柜体和支架可分离，多种支架备选
·可选配国际流行的搁手支架，使操作者更安全、更舒适
·配备安全防溅插座和实验水气嘴
■ 可靠的防护
·专利技术的前窗玻璃平衡器悬挂系统设计，杜绝因误操作而带来的实验室泄漏
·6mm厚度防紫外线钢化玻璃前窗，提供安全有效的保护
·创新的气流隔断技术，杜绝了前窗上沿和两侧的泄漏（专利号：ZL200520125549.X）
·全漏电保护设计，即使没有接地线也可放心使用
·严格的气密性检测，加压500Pa，保持30min后气压不低于450Pa
■ 安全报警设计
·门限位报警——开门高度超过安全高度报警，防止实验微生物泄漏
·气流波动报警——气流波动超过20%报警，保证气幕可靠
·关风机门未关严报警——防止实验微生物泄漏
*齐全的售后服务网络：全国售后网点超过800家

 

技术参数：HR60-IIA2

型号 安全柜类型 洁净等级 过滤效率 外形尺寸mm 操作区尺寸mm 适用人数
HR30-IIA2 A2 10级 99.9995%@0.12um —- 900×610×680 1人
HR40-IIA2 A2 10级 99.9995%@0.12um 1360×790×2200 1167×610×680 1-2人
HR60-IIA2 A2 10级 99.9995%@0.12um 1960×790×2200 1734×610×680 2-3人
HR40-IIB2 B2 10级 99.9995%@0.12um 1360×790×2300 1167×610×680 1-2人
HR60-IIB2 B2 10级 99.9995%@0.12um 1960×790×2300 1734×610×680 2-3人

 
本公司是海尔科研仪器设备上海区的总代理商，欢迎来电垂询！我们将保证提供地区*具竞争力的价格和*优质的售前、售中、售后服务!

海尔A2型生物安全柜HR40-IIA2

发表于由

海尔A2型生物安全柜HR40-IIA2

产品型号： HR40-IIA2 品  牌： 海尔

■ 海尔生物安全柜HR40-IIA2让您享受工作的乐趣
·操作省心：所有异常状态全部设置了报警提示，对误操作均设置连锁保护，即使没有经过培训，也不会造成伤害。此项设计被鉴定为国际领先水平，并被授予国家专利（专利号：ZL200520125227.5）
·使用安心：运行状态全部显示,一目了然获知风机、过滤器、紫外灯、气流等各项运行指标
■ 完美的结构
·符合人体工程学原理的10°倾斜角设计，操作感受更佳
·工作区三侧壁板采用不锈钢一体化结构，12mm大圆弧过渡避免清洁死角
·柜体和支架可分离，多种支架备选
·可选配国际流行的搁手支架，使操作者更安全、更舒适
·配备安全防溅插座和实验水气嘴
■ 可靠的防护
·专利技术的前窗玻璃平衡器悬挂系统设计，杜绝因误操作而带来的实验室泄漏
·6mm厚度防紫外线钢化玻璃前窗，提供安全有效的保护
·创新的气流隔断技术，杜绝了前窗上沿和两侧的泄漏（专利号：ZL200520125549.X）
·全漏电保护设计，即使没有接地线也可放心使用
·严格的气密性检测，加压500Pa，保持30min后气压不低于450Pa
■ 安全报警设计
·门限位报警——开门高度超过安全高度报警，防止实验微生物泄漏
·气流波动报警——气流波动超过20%报警，保证气幕可靠
·关风机门未关严报警——防止实验微生物泄漏
*齐全的售后服务网络：全国售后网点超过800家

 

技术参数：HR40-IIA2

型号 安全柜类型 洁净等级 过滤效率 外形尺寸mm 操作区尺寸mm 适用人数
HR30-IIA2 A2 10级 99.9995%@0.12um —- 900×610×680 1人
HR40-IIA2 A2 10级 99.9995%@0.12um 1360×790×2200 1167×610×680 1-2人
HR60-IIA2 A2 10级 99.9995%@0.12um 1960×790×2200 1734×610×680 2-3人
HR40-IIB2 B2 10级 99.9995%@0.12um 1360×790×2300 1167×610×680 1-2人
HR60-IIB2 B2 10级 99.9995%@0.12um 1960×790×2300 1734×610×680 2-3人

 
本公司是海尔科研仪器设备上海区的总代理商，欢迎来电垂询！我们将保证提供地区*具竞争力的价格和*优质的售前、售中、售后服务!

海尔A2型生物安全柜HR30-IIA2

发表于由

海尔A2型生物安全柜HR30-IIA2

产品型号： HR30-IIA2 品  牌： 海尔

■ 海尔生物安全柜HR30-IIA2让您享受工作的乐趣
·操作省心：所有异常状态全部设置了报警提示，对误操作均设置连锁保护，即使没有经过培训，也不会造成伤害。此项设计被鉴定为国际领先水平，并被授予国家专利（专利号：ZL200520125227.5）
·使用安心：运行状态全部显示,一目了然获知风机、过滤器、紫外灯、气流等各项运行指标
■ 完美的结构
·符合人体工程学原理的10°倾斜角设计，操作感受更佳
·工作区三侧壁板采用不锈钢一体化结构，12mm大圆弧过渡避免清洁死角
·柜体和支架可分离，多种支架备选
·可选配国际流行的搁手支架，使操作者更安全、更舒适
·配备安全防溅插座和实验水气嘴
■ 可靠的防护
·专利技术的前窗玻璃平衡器悬挂系统设计，杜绝因误操作而带来的实验室泄漏
·6mm厚度防紫外线钢化玻璃前窗，提供安全有效的保护
·创新的气流隔断技术，杜绝了前窗上沿和两侧的泄漏（专利号：ZL200520125549.X）
·全漏电保护设计，即使没有接地线也可放心使用
·严格的气密性检测，加压500Pa，保持30min后气压不低于450Pa
■ 安全报警设计
·门限位报警——开门高度超过安全高度报警，防止实验微生物泄漏
·气流波动报警——气流波动超过20%报警，保证气幕可靠
·关风机门未关严报警——防止实验微生物泄漏
*齐全的售后服务网络：全国售后网点超过800家

 

技术参数：HR30-IIA2

型号 安全柜类型 洁净等级 过滤效率 外形尺寸mm 操作区尺寸mm 适用人数
HR30-IIA2 A2 10级 99.9995%@0.12um —- 900×610×680 1人
HR40-IIA2 A2 10级 99.9995%@0.12um 1360×790×2200 1167×610×680 1-2人
HR60-IIA2 A2 10级 99.9995%@0.12um 1960×790×2200 1734×610×680 2-3人
HR40-IIB2 B2 10级 99.9995%@0.12um 1360×790×2300 1167×610×680 1-2人
HR60-IIB2 B2 10级 99.9995%@0.12um 1960×790×2300 1734×610×680 2-3人

 
本公司是海尔科研仪器设备上海区的总代理商，欢迎来电垂询！我们将保证提供地区*具竞争力的价格和*优质的售前、售中、售后服务!

Mogroside IIA1(Synonyms: 罗汉果苷 IIA1；罗汉果甜苷 IIA1；罗汉果甙 IIA1；罗汉果甜甙 IIA1)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Mogroside IIA1;(Synonyms: 罗汉果苷 IIA1；罗汉果甜苷 IIA1；罗汉果甙 IIA1；罗汉果甜甙 IIA1) 纯度: 99.83%

Mogroside IIA1 是一种三萜糖苷。Mogroside IIA1 是一种非糖类甜味剂。Mogroside 比蔗糖更甜。Mogroside 具有抗氧化，抗糖尿病和抗癌活性。

Mogroside IIA1(Synonyms: 罗汉果苷 IIA1；罗汉果甜苷 IIA1；罗汉果甙 IIA1；罗汉果甜甙 IIA1)

Mogroside IIA1 Chemical Structure

CAS No. : 88901-44-4

规格 价格 是否有货 数量
5 mg ￥3360 In-stock
10 mg ￥5710 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Mogroside IIA1 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Diabetes Related Compound Library
  • Glycoside Compound Library
  • Medicine Food Homology Compound Library
  • Terpenoids Library

生物活性

Mogroside IIA1 is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities[1].

分子量

801.01

Formula

C42H72O14
CAS 号

88901-44-4
中文名称

罗汉果苷 IIA1；罗汉果甜苷 IIA1；罗汉果甙 IIA1；罗汉果甜甙 IIA1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)
参考文献

  • [1]. Itkin M, et al. The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii.Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7619-E7628.

11-Oxomogroside IIa(Synonyms: 11-氧代葡萄糖苷IIa)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

11-Oxomogroside IIa;(Synonyms: 11-氧代葡萄糖苷IIa) 纯度: 99.77%

11-Oxomogroside IIa 11-氧代葡萄糖苷 IIa 是从 Siraitia grosVenorii 的果实中提取的葫芦烷糖苷。 11-Oxomogroside IIa 对 12-O-十四烷基佛波醇-13-乙酸酯 (TPA) 诱导的 Epstein-Barr 病毒早期抗原 (EBV-EA) 活化具有抑制作用，对 NOR 1 (NO 供体) 的活化具有弱抑制作用。

11-Oxomogroside IIa(Synonyms: 11-氧代葡萄糖苷IIa)

11-Oxomogroside IIa Chemical Structure

规格 价格 是否有货 数量
5 mg ￥3360 In-stock
10 mg ￥5710 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

11-Oxomogroside IIa 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Natural Product Library
  • Antiviral Compound Library
  • Glycoside Compound Library
  • Medicine Food Homology Compound Library
  • Terpenoids Library

生物活性

11-Oxomogroside IIa (11-oxomogroside II A1) is a cucurbitane glycoside extracted from the fruits of Siraitia grosVenorii. 11-Oxomogroside IIa has inhibitory effects against the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), shows weak inhibitory effects on activation of (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor[1].

分子量

799.00

Formula

C42H70O14
中文名称

11-氧代葡萄糖苷IIa
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture and light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Akihisa T, et al. Cucurbitane glycosides from the fruits of Siraitia gros venorii and their inhibitory effects on Epstein-Barr virus activation. J Nat Prod. 2007 May;70(5):783-8. Epub 2007 May 4.

Cucurbitacin IIa(Synonyms: Hemslecin A)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Cucurbitacin IIa (Synonyms: Hemslecin A) 纯度: 99.27%

Cucurbitacin IIa 是从园果雪胆中分离得到的三萜烯，可诱导癌细胞凋亡。Cucurbitacin IIa 可降低癌细胞中生存素 survivin 的表达，降低磷酸化组蛋白 H3 的水平，增加裂解的 PARP 的水平。

Cucurbitacin IIa(Synonyms: Hemslecin A)

Cucurbitacin IIa Chemical Structure

CAS No. : 58546-34-2

规格 价格 是否有货 数量
5 mg ￥800 In-stock
10 mg ￥1400 In-stock
20 mg ￥2300 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Cucurbitacin IIa 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Terpenoids Library
  • Traditional Chinese Medicine Monomer Library

生物活性

Cucurbitacin IIa is a triterpene isolated from Hemsleya amalils Diels, induces apoptosis of cancer cells, reduces expression of survivin, reduces phospho-Histone H3 and increases cleaved PARP in cancer cells[1].

分子量

562.73

Formula

C32H50O8
CAS 号

58546-34-2
中文名称

葫芦素 IIa；雪胆素甲
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 25 mg/mL (44.43 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7771 mL 8.8853 mL 17.7705 mL
5 mM 0.3554 mL 1.7771 mL 3.5541 mL
10 mM 0.1777 mL 0.8885 mL 1.7771 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (1.78 mM); Clear solution

    此方案可获得 ≥ 1 mg/mL (1.78 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (1.78 mM); Clear solution

    此方案可获得 ≥ 1 mg/mL (1.78 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (1.78 mM); Clear solution

    此方案可获得 ≥ 1 mg/mL (1.78 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Boykin C, et al. Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation. Br J Cancer. 2011 Mar 1;104(5):781-9.