Icatibant acetate;(Synonyms: HOE 140 acetate) 纯度: 99.64%
Icatibant acetate (HOE-140 acetate) 是有效的,特异的缓激肽 B2 受体拮抗剂,IC50 和 Ki 值分别为 1.07 nM和 0.798 nM。
Icatibant acetate Chemical Structure
CAS No. : 138614-30-9
规格 | 价格 | 是否有货 | 数量 |
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10;mM;*;1 mL in DMSO | ¥10510 | In-stock | |
1 mg | ¥1150 | In-stock | |
5 mg | ¥3500 | In-stock | |
10 mg | ; | 询价 | ; |
50 mg | ; | 询价 | ; |
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Icatibant acetate 相关产品
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生物活性 |
Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively[1][2][3]. |
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体外研究 (In Vitro) |
Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
1364.57 |
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Formula |
C61H93N19O15S |
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CAS 号 |
138614-30-9 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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溶解性数据 |
In Vitro:;
DMSO : 100 mg/mL (73.28 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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