标签归档：icariside

Icariside I(Synonyms: Icarisid I)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Icariside I (Synonyms: Icarisid I) 纯度: 98.36%

Icariside I (Icarisid I) 是 Icarlin 的一个代谢产物，Icarlin 能够调节骨重塑，可以用于骨质疏松的相关研究。

Icariside I(Synonyms: Icarisid I)

Icariside I Chemical Structure

CAS No. : 56725-99-6

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1751 In-stock
5 mg ￥1500 In-stock
10 mg ￥2100 In-stock
25 mg ￥4200 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Icariside I 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Glycoside Compound Library
  • Phenols Library
  • Traditional Chinese Medicine Monomer Library
  • Flavonoids Library

生物活性

Icariside I is a metabolite of Icarlin, which could regulate bone remodeling and is recognized as an effective agent for the treatment of osteoporosis.

分子量

530.52

Formula

C27H30O11
CAS 号

56725-99-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro: 

DMSO : 62.5 mg/mL (117.81 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8849 mL 9.4247 mL 18.8494 mL
5 mM 0.3770 mL 1.8849 mL 3.7699 mL
10 mM 0.1885 mL 0.9425 mL 1.8849 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (3.92 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.08 mg/mL (3.92 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (3.92 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.08 mg/mL (3.92 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Cheng T, et al. Metabolism profiles of icariin in rats using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry and in vitro enzymatic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 15;1033-1034:353-360.

    [2]. Ming LG, et al. Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling. J Cell Physiol. 2013 Mar;228(3):513-21.

Icariside B1(Synonyms: 淫羊藿次甙B1；淫羊藿次甙 B1；淫羊藿次苷B1)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Icariside B1 (Synonyms: 淫羊藿次甙B1；淫羊藿次甙 B1；淫羊藿次苷B1)

Icariside B1 是一种从 Petasites tricholobus Franch 分离出来的降碳倍半萜类化合物，具有抗癌作用。

Icariside B1(Synonyms: 淫羊藿次甙B1；淫羊藿次甙 B1；淫羊藿次苷B1)

Icariside B1 Chemical Structure

CAS No. : 109062-00-2

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

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生物活性

Icariside B1 is a megastigmane glycoside compound isolated from Petasites tricholobus Franch, with an anticancer effect[1][2].

分子量

386.44

Formula

C19H30O8
CAS 号

109062-00-2
中文名称

淫羊藿次甙B1；淫羊藿次甙 B1；淫羊藿次苷B1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yong Zhang, et al. Two new sulfated sesquiterpenoids from Petasites tricholobus. Yao Xue Xue Bao. 2014 Oct;49(10):1433-7.

    [2]. Nguyen Thi Thu Hien, et al. Chemical constituents of the Annona glabra fruit and their cytotoxic activity. Pharm Biol. 2015;53(11):1602-7.

Icariside E5(Synonyms: 淫羊藿次甙E5)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Icariside E5;(Synonyms: 淫羊藿次甙E5) 纯度: ge;93.0%

Icariside E5 是从 Albiziae Cortex 分离得到的木脂素糖苷。Icariside E5 促进 HUVEC 的增殖而无细胞毒性。Icariside E5 具有抗氧化性能。

Icariside E5(Synonyms: 淫羊藿次甙E5)

Icariside E5 Chemical Structure

CAS No. : 126176-79-2

规格 价格 是否有货 数量
5 mg ￥18500 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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生物活性

Icariside E5 is a lignan glycoside isolated from the Albiziae Cortex. Icariside E5 promotes the proliferation of HUVECs without cytotoxicity. Icariside E5 has antioxidant properties[1][2].

体外研究
(In Vitro)

Icariside E5 (5, 10, 20, 40 µM; for 48 h) slightly promotes the proliferation of human umbilical vein endothelial cells (HUVECs). Icariside E5 does not have the pharmacological effect of scavenging ROS[1].
Icariside E neither induces an increase in the intracellular levels of reactive oxygen species nor affects the mitochondria permeability transition, and it does not signal through the vanilloid receptor type 1. It protects Jurkat cells from apoptosis induced by the oxidative stress mediated by serum withdrawal[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

522.54

Formula

C26H34O11
CAS 号

126176-79-2
中文名称

淫羊藿次甙E5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture and light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Xuelin Shi, et al. Chemical Constituents from Albiziae Cortex and Their Ability to Ameliorate Steatosis and Promote Proliferation and Anti-Oxidation In Vitro. Molecules. 2019 Nov 7;24(22):4041.

    [2]. M Iorizzi, et al. New glycosides from Capsicum annuum L. var. acuminatum. Isolation, structure determination, and biological activity. J Agric Food Chem. 2001 Apr;49(4):2022-9.

Icariside D2

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Icariside D2;

Icariside D2 可从Annona glabra 中分离得到，可抑制血管紧张素转换酶。Icariside 对HL-60 细胞的IC50 值为9.0 ± 1.0 μM。Icariside D2 可诱导凋亡。

Icariside D2

Icariside D2 Chemical Structure

CAS No. : 38954-02-8

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

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生物活性

Icariside D2, isolated from Annona glabra fruit, inhibits angiotensin-converting enzyme. Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC50 value of 9.0 ± 1.0 μM. Icariside D2 induces apoptosis [1][2].

体外研究
(In Vitro)

Icariside D2 3 induces apoptosis via alteration of expression of apoptosis-related proteins and decreases phosphorylation of AKT in HL-60 cells[1].
Icariside D2 exhibits anti-inflammatory and anti-HIV activity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

300.30

Formula

C14H20O7
CAS 号

38954-02-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Nguyen Thi Thu Hien, et al. Chemical Constituents of the Annona Glabra Fruit and Their Cytotoxic Activity. Pharm Biol. 2015;53(11):1602-7.

    [2]. Xue Liu, et al. Metabolic Engineering Escherichia coli for Efficient Production of Icariside D2. Biotechnol Biofuels. 2019 Nov 6;12:261.

    [3]. Jin-YuLi, et al. Three new acylated prenylflavonol glycosides from Epimedium koreanum. Phytochemistry Letters Volume 17, September 2016, Pages 206-212.

Icariside F2(Synonyms: 淫羊藿次苷F2)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Icariside F2;(Synonyms: 淫羊藿次苷F2)

Icariside F2 是有效的 NF-κB 抑制剂，IC50 值为 16.25 μM。Icariside F2 是从 E.ulmoides Oliver 的叶子中分离出来的一种芳香糖苷。Icariside F2 具有抗炎作用。

Icariside F2(Synonyms: 淫羊藿次苷F2)

Icariside F2 Chemical Structure

CAS No. : 115009-57-9

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

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生物活性

Icariside F2 is a potent NF-κB inhibitor with an IC50 value of 16.25 μM. Icariside F2 is an aromatic glycoside isolated from the leaves of E. ulmoides Oliver. Icariside F2 has anti-inflammatory activity[1].

IC50 Target[1]

NF-κB

16.25 mu;M (IC50)

体外研究
(In Vitro)

At a concentration of 10 μΜ, Icariside F2 shows little or no cytotoxic activity by the MTT assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

402.39

Formula

C18H26O10
CAS 号

115009-57-9
中文名称

淫羊藿次苷F2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Meng-Meng Bai, et al. Soluble epoxide hydrolase inhibitory and anti-inflammatory components from the leaves of Eucommia ulmoides Oliver (duzhong). J Agric Food Chem. 2015 Mar 4;63(8):2198-205.