HS014

发表于2024年7月12日由Whatman官网

HS014;

HS014 是一种高效、选择性的黑素皮质素-4 (MC4) 受体拮抗剂，对人 MC4、MC1、MC3 和 MC5 受体的 K_i 值分别为 3.16、108、54.4 和 694 nM。HS014 调节吗啡对小鼠行为的影响。HS014 增加自由喂养大鼠的食物摄取量。

HS014 Chemical Structure

CAS No. : 207678-81-7

规格	价格	是否有货
1 mg	￥4500	询问价格货期
5 mg	￥13500	询问价格货期

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HS014 的其他形式现货产品:

HS014 TFA

生物活性	HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with K_is of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats^[1]^[2]^[3].
体内研究 (In Vivo)	The dose-effect curve of morphine for locomotor activity was shifted downwards in C57Bl/6 mice pretreated with HS014 and in A(y) mice. The dose-effect curve of morphine for antinociception is shifted two- and threefold to the left in C57Bl/6 mice pretreated with HS014 and in A(y) mice, respectively^[2]. Pretreatment with HS014 blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate^[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	1563.76
Formula	C₇₁H₉₄N₂₀O₁₇S₂
CAS 号	207678-81-7
Sequence	Ac-Cys-Glu-His-{D-2Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Cys1-Cys8)
Sequence Shortening	Ac-CEH-{D-2Nal}-RWGCPPKD-NH2 (Disulfide bridge:Cys1-Cys8)
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Schiöth HB,et al. Discovery of novel melanocortin4 receptor selective MSH analogues. Br J Pharmacol. 1998;124(1):75-82. [2]. Ercil NE, et al. HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in mice. Psychopharmacology (Berl). 2005;180(2):279-285. [3]. Kask A, et al. Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats. Biochem Biophys Res Commun. 1998;245(1):90-93.

荧光染料HS-131

发表于2024年5月6日由Whatman官网

荧光染料Dye Reagents HS-131;

HS-131 是一种近红外 Hsp90 的染料抑制剂，能够检测原癌基因驱动的乳腺癌，并能识别不同的人类乳腺癌分子亚型。

HS-131 Chemical Structure

CAS No. : 2084850-40-6

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

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生物活性

HS-131, a near infrared dye tethered Hsp90 inhibitor, is able to detect oncogene-driven breast cancers, including multiple different molecular subtypes of human breast cancers^[1].

体外研究
(In Vitro)

Immunofluorescence^[1]

Cell Line:	Tumor cells.
Concentration:	10 µM.
Incubation Time:	30 min.
Result:	Tissues/organs, including eyes, brain, heart, lung, liver, spleen, kidney, gut, urinary bladder and skin, were imaged ex vivo by the IVIS imager machine, an imaging modality that detects IR at 640 nm.

体内研究
(In Vivo)

HS131 (10 nmol/mouse) could label breast cancers with different molecular subtypes, including MCF-7 and T-47D for luminal type, BT474M1 and KPL-4 for HER2+ subtype, MDA-MB-231 and MDA-MB-468 for triple negative subtype were chosen after considering the tumorigenic capacities of breast cancer cell lines in SCID mice^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	SCID-beige mice bearing human breast cancer xenografts of different molecular subtypes^[1].
Dosage:	10 nmol/mouse.
Administration:	Injected intravenously.
Result:	All breast cancer xenografts with different molecular subtypes showed stronger nIR signals in tumor by intravenous administration of HS131 compared to HS152, and the retention of the nIR signals was detectable even at the 24 h time point in HS131 injected mice.

分子量

1318.68

Formula

C₇₁H₉₅N₇O₁₃S₂

CAS 号

2084850-40-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Takuya Osada, et al. In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior. Clin Cancer Res. 2017 Dec 15;23(24):7531-7542.

HS014 TFA

发表于2024年4月15日由Whatman官网

HS014 TFA; 纯度: 98.81%

HS014 TFA 是一种高效、选择性的黑素皮质素-4 (MC4) 受体拮抗剂，对人 MC4、MC1、MC3 和 MC5 受体的 K_i 值分别为 3.16、108、54.4 和 694 nM。HS014 TFA 调节吗啡对小鼠行为的影响。HS014 TFA 增加自由喂养大鼠的食物摄取量。

HS014 TFA Chemical Structure

规格	价格	是否有货	数量
1 mg	￥4500	In-stock
5 mg	￥13500	In-stock
10 mg	;	询价	;
50 mg	;	询价	;

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HS014 TFA 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Macrocyclic Compound Library
Peptide Library

生物活性

HS014 TFA is a potent and selective melanocortin-4 (MC4) receptor antagonist, with K_is of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors respectively. HS014 TFA modulates the behavioral effects of morphine in mice. HS014 TFA increases food intake in free-feeding rats^[1]^[2]^[3].

体内研究
(In Vivo)

The dose-effect curve of morphine for locomotor activity was shifted downwards in C57Bl/6 mice pretreated with HS014 TFA and in A(y) mice. The dose-effect curve of morphine for antinociception is shifted two- and threefold to the left in C57Bl/6 mice pretreated with HS014 TFA and in A(y) mice, respectively^[2].
Pretreatment with HS014 TFA blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1677.78

Formula

C₇₃H₉₅F₃N₂₀O₁₉S₂

Sequence

Ac-Cys-Glu-His-{D-2Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Cys1-Cys8)

Sequence Shortening

Ac-CEH-{D-2Nal}-RWGCPPKD-NH2 (Disulfide bridge:Cys1-Cys8)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80deg;C	2 years
	-20deg;C	1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

参考文献

[1]. Schiöth HB,et al. Discovery of novel melanocortin4 receptor selective MSH analogues. Br J Pharmacol. 1998;124(1):75-82.

[2]. Ercil NE, et al. HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in mice. Psychopharmacology (Berl). 2005;180(2):279-285.

[3]. Kask A, et al. Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats. Biochem Biophys Res Commun. 1998;245(1):90-93.

CAY10731

发表于2024年4月7日由Whatman官网

CAY10731;

CAY10731 (compound 3) 是一种用于检测硫化氢 (H₂S) 的高选择性荧光探针。CAY10731 用于监测癌细胞和正常细胞中的外源性和内源性 H₂S。CAY10731 用于对不同深度的活组织和线虫中的 H₂S 进行成像。

CAY10731 Chemical Structure

CAS No. : 2119597-33-8

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

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生物活性	CAY10731 (compound 3) is a highly selective fluorescent probe for detection of hydrogen sulfide (H₂S). CAY10731 is used to monitor exo- and endogenous H₂S in both cancer and normal cells. CAY10731 is applied for imaging of H₂S in living tissues at variable depths and in nematodes^[1].
分子量	497.29
Formula	C₂₄H₁₇BrO₇
CAS 号	2119597-33-8
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Shahi Imam Reja, et al.A Highly Selective Fluorescent Probe for Detection of Hydrogen Sulfide in Living Systems: In Vitro and in Vivo Applications. Chemistry. 2017 Jul 21;23(41):9872-9878.

肽聚糖、β-葡聚糖检测试剂——SLP-HS单试剂套装II

发表于2024年3月30日由Whatman官网

肽聚糖、β-葡聚糖检测试剂——SLP-HS单试剂套装II

本产品为冻干粉，含有从蚕体液中经无菌提取而配制成的酚氧化酶（ProPO）级联反应的全部因子。通过肽聚糖（PG）和β-葡聚糖可活化本产品，并氧化套装中底物中所含的DOPA（L-3,4二羟基），产生黑色素。由于在大多数细菌的细胞壁存在PG，而多数真菌细胞壁存在β-葡聚糖，因此将通过PG和β-葡聚糖产生的黑色素作为指示剂，可检测全部微生物。

◆特点

●　使用Toxinometer^® 可高灵敏性地定量肽聚糖和β-葡聚糖

肽聚糖、β-葡聚糖检测试剂——SLP-HS单试剂套装II

图1. 蚕血的酚氧化酶活化酶前体级联反应

◆试剂盒组成

肽聚糖、β-葡聚糖检测试剂——SLP-HS单试剂套装II

SLP-HS^*1 Reagent II（灵敏度：10 pg/mL（PG））	0.1 mL用×20瓶
SLP-Diluent	5 mL×2瓶
Standard（Digested Peptidoglycan from S. aureus ）	0.5 mL×1瓶

*1：Silkworm Larvae Plasma High Sensitive

◆产品列表

产品编号	产品名称	规格	包装
296-81001	SLP-HS Single Reagent Set II	微生物检测用	20次用

◆相关产品

产品编号

产品名称

规格

包装

030-09903

Curdlan^*2

凝胶多糖

生化学用

1 g

*2：（1→3）-β-D-葡聚糖

Limulus Amebocyte Lysate HS-F (Sensitivity 0.03EU/ml) 鲎试剂LAL HS-F（适用于溶胶凝胶法和动态比浊法）品牌：FUJIFILM Wako

发表于2024年3月18日由Whatman官网

Limulus Amebocyte Lysate HS-F (Sensitivity 0.03EU/ml)

鲎试剂LAL HS-F（适用于溶胶凝胶法和动态比浊法）

品牌：FUJIFILM Wako
CAS No.：
储存条件：2-10℃
纯度：–

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
290-52711	for Endotoxin Detection	5 ml	–	咨询	–	–

* 干冰运输、大包装及大批量的产品需酌情添加运输费用

* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

SLP-HS Single Reagent Set Ⅱ 高灵敏度SLP试剂盒Ⅱ（独立包装）品牌：FUJIFILM Wako

发表于2024年3月18日由Whatman官网

SLP-HS Single Reagent Set Ⅱ

高灵敏度SLP试剂盒Ⅱ（独立包装）

品牌：FUJIFILM Wako
CAS No.：
储存条件：2-10℃
纯度：–

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
296-81001	for Microorganism Detection	20Tests	–	咨询	–	–

* 干冰运输、大包装及大批量的产品需酌情添加运输费用

Limulus HS-T Single Test wako 鲎试剂HS-T Single（适用于溶胶凝胶法和动态比浊法）品牌：FUJIFILM Wako

发表于2024年3月18日由Whatman官网

Limulus HS-T Single Test wako

鲎试剂HS-T Single（适用于溶胶凝胶法和动态比浊法）

品牌：FUJIFILM Wako
CAS No.：
储存条件：2-10℃
纯度：–

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
299-53401	for Endotoxin Detection	25Tests	–	咨询	–	–

* 干冰运输、大包装及大批量的产品需酌情添加运输费用

CheckLite HS Set（100 assays) ATP检测试剂HS试剂盒（C-110配套用）品牌：Kikkoman

发表于2024年3月17日由Whatman官网

CheckLite HS Set（100 assays)

ATP检测试剂HS试剂盒（C-110配套用）

品牌：Kikkoman
CAS No.：
储存条件：2-10℃
纯度：–

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
60315	–	100 tests	–	咨询	–	–

* 干冰运输、大包装及大批量的产品需酌情添加运输费用

CheckLite HS Set（100 assays) ATP检测试剂HS试剂盒（C-110配套用）品牌：Kikkoman

发表于2024年3月16日由Whatman官网

CheckLite HS Set（100 assays)

ATP检测试剂HS试剂盒（C-110配套用）

品牌：Kikkoman
CAS No.：
储存条件：2-10℃
纯度：–

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
61310	–	100 tests	–	5,610.00	–	–

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Cytiva思拓凡-Whatman滤纸滤膜滤器

沃特曼官网代理商|Whatman滤纸滤膜中国官网代理商

标签归档：hs

HS014

荧光染料HS-131

HS014 TFA

HS014 TFA 相关产品

bull;相关化合物库:

CAY10731

肽聚糖、β-葡聚糖检测试剂——SLP-HS单试剂套装II

肽聚糖、β-葡聚糖检测试剂——SLP-HS单试剂套装II

Limulus Amebocyte Lysate HS-F (Sensitivity 0.03EU/ml) 鲎试剂LAL HS-F（适用于溶胶凝胶法和动态比浊法）品牌：FUJIFILM Wako

Limulus Amebocyte Lysate HS-F (Sensitivity 0.03EU/ml)

鲎试剂LAL HS-F（适用于溶胶凝胶法和动态比浊法）

SLP-HS Single Reagent Set Ⅱ 高灵敏度SLP试剂盒Ⅱ（独立包装）品牌：FUJIFILM Wako

SLP-HS Single Reagent Set Ⅱ

高灵敏度SLP试剂盒Ⅱ（独立包装）

Limulus HS-T Single Test wako 鲎试剂HS-T Single（适用于溶胶凝胶法和动态比浊法）品牌：FUJIFILM Wako

Limulus HS-T Single Test wako

鲎试剂HS-T Single（适用于溶胶凝胶法和动态比浊法）

CheckLite HS Set（100 assays) ATP检测试剂HS试剂盒（C-110配套用）品牌：Kikkoman

CheckLite HS Set（100 assays)

ATP检测试剂HS试剂盒（C-110配套用）

CheckLite HS Set（100 assays) ATP检测试剂HS试剂盒（C-110配套用）品牌：Kikkoman

CheckLite HS Set（100 assays)

ATP检测试剂HS试剂盒（C-110配套用）

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