标签归档：hiv

Reverse Transcriptase, HIV-1, recombinant, Solution 逆转录酶HIV-1 品牌：FUJIFILM Wako

发表于由

Reverse Transcriptase, HIV-1, recombinant, Solution

逆转录酶HIV-1

品牌：FUJIFILM Wako
CAS No.：
储存条件：-80℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

183-02241

 for Cellbiology 0.02 mg(protein) –

Reverse Transcriptase, HIV-1, recombinant, Solution 逆转录酶HIV-1 品牌：FUJIFILM Wako

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

HIV gag peptide (197-205)

发表于由

HIV gag peptide (197-205);

HIV gag peptide (197-205) 是一种来源于 HIV-1 gag 蛋白 p24 部分的 H-2Kd 限制性表位多肽，对应氨基酸残基序列 197-205 (AMQMLKETI)。

HIV gag peptide (197-205)amp;;

HIV gag peptide (197-205) Chemical Structure

CAS No. : 214978-47-9

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

HIV gag peptide (197-205) is a H-2Kd-restricted epitope derived from the p24 portion of the HIV-1 gag protein, consists of amino acids 197-205 (AMQMLKETI)[1].

分子量

1064.32

Formula

C45H81N11O14S2
CAS 号

214978-47-9
Sequence Shortening

AMQMLKETI
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lin J, et al. A new genetic vaccine platform based on an adeno-associated virus isolated from a rhesus macaque. J Virol. 2009 Dec;83(24):12738-50.

Reverse Transcriptase, HIV-1, recombinant, Solution 逆转录酶HIV-1 品牌：FUJIFILM Wako

发表于由

Reverse Transcriptase, HIV-1, recombinant, Solution

逆转录酶HIV-1

品牌：FUJIFILM Wako
CAS No.：
储存条件：-80℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

189-02243

 for Cellbiology 0.1 mg(protein) –

Reverse Transcriptase, HIV-1, recombinant, Solution 逆转录酶HIV-1 品牌：FUJIFILM Wako

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

HIV Protease Substrate 1 TFA

发表于由

HIV Protease Substrate 1 TFA;

HIV Protease Substrate 1 TFA 是一种外源性 HIV 蛋白酶底物，可用于研究 HIV 蛋白酶的酶活性。

HIV Protease Substrate 1 TFAamp;;

HIV Protease Substrate 1 TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

HIV Protease Substrate 1 TFA, a fiuorogenic HIV protease substrate, can be used to study enzymatic activity of HIV protease[1].

分子量

2131.29

Formula

C94H134F3N27O25S
Sequence

Arg-{Glu(EDANS)}-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys{(DABCYL)}-Arg
Sequence Shortening

R{Glu(EDANS)}SQNYPIVQ{Lys(DABCYL)}R
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kapewangolo P, et al. Anti-HIV Activity of Ocimum labiatum Extract and Isolated Pheophytin-a. Molecules. 2017;22(11):1763. Published 2017 Nov 6.

(Cys47)-HIV-1 tat Protein (47-57)

发表于由

(Cys47)-HIV-1 tat Protein (47-57);

(Cys47)-HIV-1 tat Protein (47-57) 具有膜移位功能，可用于衍生磁性药物的表面，并促进其被吸收到靶细胞中。

(Cys47)-HIV-1 tat Protein (47-57)amp;;

(Cys47)-HIV-1 tat Protein (47-57) Chemical Structure

CAS No. : 627079-23-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

(Cys47)-HIV-1 tat Protein (47-57) has membrane translocation function and can be used to derivatize the surface of magnetic pharmaceuticals and substantially facilitated their uptake into target cells[1][2].

分子量

1499.80

Formula

C58H114N32O13S
CAS 号

627079-23-6
Sequence

Cys-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg
Sequence Shortening

CGRKKRRQRRR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Chumki Dalal, et al. Multivalency Effect of TAT-Peptide-Functionalized Nanoparticle in Cellular Endocytosis and Subcellular Trafficking. J Phys Chem B. 2017 Apr 13;121(14):2942-2951.

    [2]. Ming Zhao, et al. Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjug Chem. Jul-Aug 2002;13(4):840-4.

HIV-1 Rev (34-50)(Synonyms: HIV-1 rev Protein (34-50))

发表于由

HIV-1 Rev (34-50);(Synonyms: HIV-1 rev Protein (34-50))

HIV-1 Rev (34-50) 是由 17 个氨基酸组成的多肽，来源于 HIV Rev 蛋白的 Rev 响应元素 (RRE) 结合域，具有抗 HIV 的活性。

HIV-1 Rev (34-50)amp;;(Synonyms: HIV-1 rev Protein (34-50))

HIV-1 Rev (34-50) Chemical Structure

CAS No. : 141237-50-5

规格 价格 是否有货
500 μg ￥2200 询问价格 货期
1 mg ￥3500 询问价格 货期
5 mg ￥5500 询问价格 货期

* Please select Quantity before adding items.

生物活性

HIV-1 Rev (34-50) is a 17-aa peptide derived from the Rev-responsive element (RRE)-binding domains of Rev in HIV-1, with anti-HIV-1 activity.

IC50 Target

HIV[1]
体外研究
(In Vitro)

HIV-1 Rev (34-50) is a 17-aa peptide derived from the Rev-responsive element (RRE)-binding domains of Rev in HIV-1, with anti-HIV-1 activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2437.74

Formula

C97H173N51O24
CAS 号

141237-50-5
Sequence

Thr-Arg-Gln-Ala-Arg-Arg-Asn-Arg-Arg-Arg-Arg-Trp-Arg-Glu-Arg-Gln-Arg
Sequence Shortening

TRQARRNRRRRWRERQR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Shimane K, et al. Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4. Int J Biochem Cell Biol. 2010 Sep;42(9):1482-8.

Scutellarin(Synonyms: 野黄芩苷)

发表于由

天然产物 黄酮类 Flavonoids

Scutellarin (Synonyms: 野黄芩苷) 纯度: ≥98.0%

Scutellarin 是从黄芩中分离到的黄酮类物质，在 HCC 细胞中，能够下调 STAT3/Girdin/Akt 信号通路，在破骨细胞中，能够抑制 RANKL 介导的 MAPK/NF-κB 信号通路。Scutellarin 具有抗 HIV-1IIIB，HIV-1(74V) 和 HIV-1KM018 的活性，EC50 分别为 26 μM，253 μM 和 136 μM。

Scutellarin(Synonyms: 野黄芩苷)

Scutellarin Chemical Structure

CAS No. : 27740-01-8

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥500 In-stock
10 mg ￥450 In-stock
25 mg ￥780 In-stock
50 mg ￥1400 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Scutellarin 相关产品

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生物活性

Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively.

IC50 & Target[1]

STAT3

 

Akt

 

体外研究
(In Vitro)

Scutellarin treatment significantly reduces HepG2 cell viability in a dose-dependent manner, and inhibits migration and invasion of HCC cells in vitro. Scutellarin treatment significantly reduces STAT3 and Girders of actin filaments (Girdin) expression, STAT3 and Akt phosphorylation in HCC cells. Introduction of STAT3 overexpression restores the scutellarin-downregulated Girdin expression, Akt activation, migration and invasion of HCC cells. Furthermore, induction of Girdin overexpression completely abrogates the inhibition of scutellarin on the Akt phosphorylation, migration and invasion of HCC cells. Scutellarin can inhibit HCC cell metastasis in vivo, and migration and invasion in vitro by down-regulating the STAT3/Girdin/Akt signaling[1]. Scutellarin selectively enhances Akt phosphorylation[2]. Scutellarin is a putative therapeutic agent as it has been found to not only suppress microglial activation thus ameliorating neuroinflammation, but also enhance astrocytic reaction. Acutellarin amplifies the astrocytic reaction by upregulating the expression of neurotrophic factors among others thus indicating its neuroprotective role. Remarkably, the effects of scutellarin on reactive astrocytes are mediated by activated microglia supporting a functional “cross-talk” between the two glial types[3]. Scutellarin can suppress RANKL-mediated osteoclastogenesis, the function of osteoclast bone resorption, and the expression levels of osteoclast-specific genes (tartrate-resistant acid phosphatase (TRAP), cathepsin K, c-Fos, NFATc1). Further investigation indicates that Scutellarin can inhibit RANKL-mediated MAPK and NF-κB signaling pathway, including JNK1/2, p38, ERK1/2, and IκBα phosphorylation[5].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Scutellarin (50 mg/kg/day) significantly mitigates the lung and intrahepatic metastasis of HCC tumors in vivo. The numbers of the lung and intrahepatic metastatic tumors in the scutellarin-treated group are significantly less than that in the controls[1]. The rats treated with Scutellarin display a significant alleviation in neurobehavioral deficits compared to the SAH group. Scutellarin enhanced eNOS expression compared with SAH rats[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

462.36

Formula

C21H18O12
CAS 号

27740-01-8
中文名称

野黄芩苷；野黄芩甙；灯盏花乙素；高黄芩苷；高黄芩甙；印黄芩苷；黃芹素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (216.28 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1628 mL 10.8141 mL 21.6282 mL
5 mM 0.4326 mL 2.1628 mL 4.3256 mL
10 mM 0.2163 mL 1.0814 mL 2.1628 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 0.5% CMC-Na/saline water

    Solubility: 10 mg/mL (21.63 mM); Suspended solution; Need ultrasonic

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Ke Y, et al. Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. Biochem Biophys Res Commun. 2016 Dec 18. pii: S0006-291X(16)32174-X

    [2]. Yang LL, et al. Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal. Biochim Biophys Acta. 2016 Nov 27;1863(2):598-606.

    [3]. Wu CY, et al. Scutellarin attenuates microglia-mediated neuroinflammation and promotes astrogliosis in cerebral ischemia – a therapeutic consideration. Curr Med Chem. 2016 Nov 18. [Epub ahead of print]

    [4]. Li Q, et al. Scutellarin attenuates vasospasm through the Erk5-KLF2-eNOS pathway after subarachnoid hemorrhage in rats. J Clin Neurosci. 2016 Dec;34:264-270

    [5]. Zhao S, et al. Scutellarin inhibits RANKL-mediated osteoclastogenesis and titanium particle-induced osteolysis via suppression of NF-κB and MAPK signaling pathway. Int Immunopharmacol. 2016 Nov;40:458-465

    [6]. Zhang GH, et al. The anti-HIV-1 effect of scutellarin. Biochem Biophys Res Commun. 2005 Sep 2;334(3):812-6.
Cell Assay
[1]

HepG2 cells (1×105/well) are cultured in 96-well plates and treated in triplicate with scutellarin at concentrations of 5, 10, 20, 30, and 100 μM or vehicle alone for 24 h. The cellular viability is tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and is expressed as a percentage of proliferation versus controls.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1]

To establish an orthotopic liver xenograft model, individual mice are anesthetized with isoflurane and a small incision is made in their abdomen. Individual mice are injected with 2×106 SK-Hep1 cells in 30 μL Matrigel into their left lobe of the liver. Twenty-four hours after orthotopic liver implantation, the mice are randomized and injected intraperitoneally with scutellarin (50 mg/kg/day) or vehicle (0.9% NaCl, normal saline) daily for 35 consecutive days (n=10 per group). Subsequently, the mice are sacrificed, and their lungs and livers are excised, fixed in 10% buffered formalin and paraffin-embedded for hematoxylin and eosin staining.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Ke Y, et al. Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. Biochem Biophys Res Commun. 2016 Dec 18. pii: S0006-291X(16)32174-X

    [2]. Yang LL, et al. Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal. Biochim Biophys Acta. 2016 Nov 27;1863(2):598-606.

    [3]. Wu CY, et al. Scutellarin attenuates microglia-mediated neuroinflammation and promotes astrogliosis in cerebral ischemia – a therapeutic consideration. Curr Med Chem. 2016 Nov 18. [Epub ahead of print]

    [4]. Li Q, et al. Scutellarin attenuates vasospasm through the Erk5-KLF2-eNOS pathway after subarachnoid hemorrhage in rats. J Clin Neurosci. 2016 Dec;34:264-270

    [5]. Zhao S, et al. Scutellarin inhibits RANKL-mediated osteoclastogenesis and titanium particle-induced osteolysis via suppression of NF-κB and MAPK signaling pathway. Int Immunopharmacol. 2016 Nov;40:458-465

    [6]. Zhang GH, et al. The anti-HIV-1 effect of scutellarin. Biochem Biophys Res Commun. 2005 Sep 2;334(3):812-6.

L-Chicoric Acid(Synonyms: L-菊苣酸; (-)-Chicoric acid; trans-Caffeoyltartaric acid)

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

L-Chicoric Acid (Synonyms: L-菊苣酸; (-)-Chicoric acid; trans-Caffeoyltartaric acid) 纯度: 99.98%

L-Chicoric Acid ((-)-Chicoric acid) 是一种二咖啡酰酒石酸，是一种有效的，选择性的和可逆的 HIV-1 整合酶 (HIV-1 integrase) 抑制剂，IC50 约为 100 nM。L-Chicoric Acid 还可抑制组织培养物中的 HIV-1 的复制。

L-Chicoric Acid(Synonyms: L-菊苣酸; (-)-Chicoric acid; trans-Caffeoyltartaric acid)

L-Chicoric Acid Chemical Structure

CAS No. : 70831-56-0

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mg ￥2100 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

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生物活性

L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture[1][2][3].

IC50 & Target

IC50: ~100 nM (HIV-1 integrase)[1][2]
HIV-1[2]
体外研究
(In Vitro)

L-Chicoric Acid inhibits integration at concentrations from 500 nM to 10 μM but also inhibits entry at concentrations above 1 μM. L-Chicoric Acid clearly affects viral entry at concentrations of 5 μM and higher. L-Chicoric Acid also inhibits integration as indicated both by an increased ratio of two LTR circle DNA to cDNA and an accompanying decrease in integrated provirus. The EC50 of L-Chicoric Acid against HIV is approximately 500 nM, a concentration that does not inhibit HIV entry in H9 cells[1].
The ED50 of L-Chicoric Acid against HIVNL4-3 control virus is 400 nM, while HIVNL4-3 passaged in the presence of 8 μM L-Chicoric Acid is completely resistant to the compound[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

474.37

Formula

C22H18O12
CAS 号

70831-56-0
中文名称

L-菊苣酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (210.81 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1081 mL 10.5403 mL 21.0806 mL
5 mM 0.4216 mL 2.1081 mL 4.2161 mL
10 mM 0.2108 mL 1.0540 mL 2.1081 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (5.27 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (5.27 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (5.27 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Reinke RA, et al. L-chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro. Virology. 2004 Sep 1;326(2):203-19.

    [2]. King PJ, et al. Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase. J Virol. 1998 Oct;72(10):8420-4.

    [3]. Robinson WE Jr. L-chicoric acid, an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase, improves on the in vitro anti-HIV-1 effect of a protease inhibitor (AG1350). Antiviral Res. 1998 Aug;39(2):101-11.

可定制 HIV病毒检测卡 单环

发表于由

可定制 HIV病毒检测卡 单环

简要描述：

Whatman提供一系列用于新生儿检测的产品。这些产品还可应用于医学检验、家用血标本采集试剂盒及标本档案建立等用途。利用样本收集试纸，研究者可以从多种来源获得用 于分析的样本，不仅可从待定实验室环境中获得，还可在更复杂的条件下获得。对样本收集来说，样本的均一、稳定及特性的保持是非常重要的。Whatman为您提供的产品可满足您这方面的需求。

903样本收集纸903 Specimen Collection paper

人体液体标本的收集和转移For Body Fluid Sample Collection and Transport

自Dr. Robert*了新生儿苯酮酸尿症的检测方法后，903纸便成为人体液体标本的收集、转移、分析和建立档案用试纸的标准。903纸作为一款通过美国FDA验证通过的体外二级诊断用产品，在美国国内有着广泛的应用，在世界范围内也应用于相当多的新生儿检测项目中。对于苯酮酸尿症来说，越早检测出来，治愈的可能性越大。除此之外，903纸还可应用于半乳糖症，支链酮尿症，链状细胞贫血症等其他疾病。

稳定性保证Guaranteed Consistency

在生产试纸的过程中Whatman拥有标准的操作程序。控制精良的设备确保产品质量的均一性及各项参数的可控性。考虑到试纸的组分对产品稳定性的影响，Whatman严格地控制生产过程来保证产品组分、厚度、吸收速率及均一性的稳定。

生产过程保证Manufacture Quality Assurance

903纸由100%纯棉绒制成，无任何湿强添加剂。Whatman保证每个批号的产品在正常的使用条件下可维持12个月。903纸*符合美国FDA质量体系的相关规定。CLSI关于新生儿检测样本选择有三个关键指标；903纸对一定量的血液样本的血液吸收，血清提取及血液在试纸上斑点的大小。在这方面Whatman也满足其要求。Whatman QA在生产过程监测903纸的一定量血液样本的血液吸收，斑点大小这两个指标。另外，每一批的样品检测包括血清提取指标都由独立的实验室和新生儿疾病控制中心检测。当且仅当所有指标都符合CLSI的规范，产品方可投入市场。

后印刷保证Post-Printing Quality Assurance

在很多应用中，会把903纸印成表格形式，便于记录被检测病人的一些信息。新生儿筛选用的样本收集卡片的印刷过程是根据NCSL标准严格控制。不正确的印刷会砑光火压碎纸，影响吸附性能。因此Whatman就血液吸收时间、斑点大小等指标对印刷的产品做随机抽查。Whatman可提供这部分的分析报告。

903的其他用途Beyond Neonatal Testing

除了用于新生儿DBS检测，903纸还被广泛地应用于各种样本的收集，包括HIV，HCV，血红蛋白等血样本的收集。另外，903纸还将样本中的其他信息一并携带志医学实验室用于其他测试，例如，血铅水平测试。在流行病学研究中903纸是一种理想的收集样本的介质。

 

干燥支架Dry Rak for Collection Drying

干燥支架设计出来时便于同时干燥多个样品。将附有样本的903纸放置于支架插槽中，悬空竖立安全地进行空气干燥血液样本。支架的设计形状也使得其易于安放。

多功能新生儿卡片903 Multiple-part Neonatal Card

试纸下方可记录新生儿，父母、医生、护士的信息。每张试纸上都有一个*的序列号和条形码。收集样品区域是试纸的上方5个直径半英寸的环，每个环可吸收75-80ul的血液样本。

903蛋白保存卡Protein Saver Car

903蛋白保存卡上的样品收集区域是5个半英寸直径的圆圈。每个圆圈可吸收75-80μl的血液样本。封面上可以标注名字和收集样本的日期，并印有通用的生物危害标志，符合USPS规定，仅供研究使用。

903可折叠蛋白保护卡
903纸被附在2张封面纸之间，卡上有4个半英寸直径的圆圈用以收集样本，每个可吸收75－80μl的血液样本。采集样品后封面可折叠以保护样本，封面上印有通用的生物危害标志，符合USPS规定，仅供研究使用。

Hypoglaunine D

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Hypoglaunine D 

Hypoglaunine D 是 Triptonine B 的类似物，是一种抗 HIV 的化合物，Hypoglaunine D 抑制 H9 淋巴细胞中 HIV 病毒复制的 EC50 值为 22 μg/ml。

Hypoglaunine D

Hypoglaunine D Chemical Structure

CAS No. : 220751-00-8

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生物活性

Hypoglaunine D is an analogue of Triptonine B and acts as an anti-HIV compound. Hypoglaunine D inhibits HIV replication in H9 lymphocytes with an EC50 value of 22 μg/ml[1].

IC50 & Target

IC50: HIV[1]
分子量

857.81

Formula

C41H47NO19
CAS 号

220751-00-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. H Duan, et al. Sesquiterpene alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: a new class of potent anti-HIV agents. J Nat Prod. 2000 Mar;63(3):357-61.