Hinokiflavone(Synonyms: 扁柏双黄酮)

天然产物 黄酮类 Flavonoids

Hinokiflavone (Synonyms: 扁柏双黄酮) 纯度: 99.95%

Hinokiflavone,是 pre-mRNA 剪接活性的一种新型调节剂,在体内外均有效。 Hinokiflavone 通过抑制剪接体装配来阻止前 mRNA 底物的剪接,特别是阻止 B complex 的形成。Hinokiflavone是 SUMO protease 蛋白酶抑制剂,可抑制前哨蛋白特异性蛋白酶 1 (SENP1) 的活性。

Hinokiflavone(Synonyms: 扁柏双黄酮)

Hinokiflavone Chemical Structure

CAS No. : 19202-36-9

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Hinokiflavone 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Hinokiflavone is a novel modulator of pre-mRNA splicing activity in vitro and in cellulo. Hinokiflavone blocks splicing of pre-mRNA substrates by inhibiting spliceosome assembly, specifically preventing B complex formation. Hinokiflavone is a SUMO protease inhibitor, inhibiting sentrin-specific protease 1 (SENP1) activity[1].

分子量

538.46

Formula

C30H18O10

CAS 号

19202-36-9

中文名称

扁柏双黄酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献
  • [1]. Pawellek A, et al. Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP. Elife. 2017 Sep 8;6. pii: e27402.