标签归档：hexapeptide

Argireline(Synonyms: 六胜肽 Acetyl hexapeptide-3)

发表于由

Argireline;(Synonyms: 六胜肽; Acetyl hexapeptide-3) 纯度: ge;99.0%

Argireline (Acetyl hexapeptide-3) 是一种无毒，可渗透皮肤的抗皱肽。Argireline 可显着抑制神经肌肉接头处依赖 Ca2+ 的神经递质释放。Argireline 具有抗皱和抗衰老的作用。

Argirelineamp;;(Synonyms: 六胜肽; Acetyl hexapeptide-3)

Argireline Chemical Structure

CAS No. : 616204-22-9

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
5 mg ￥500 In-stock
10 mg ￥600 In-stock
50 mg ￥690 In-stock
100 mg ￥980 In-stock
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500 mg ; 询价 ;

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Argireline 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Argireline (Acetyl hexapeptide-3) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline significantly inhibits Ca2+ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline has antiwrinkle and anti-aging activity[1][2][3].

体外研究
(In Vitro)

The incubation of Argireline solution in different concentrations with human embryonic kidney HEK-293 (IC50 of 34.862 μM) and neuroblastoma IMR-32 cells (IC50 of 68.458 μM)) for 48 h have dose dependent antiproliferative effect. Argireline solution incubated in different concentrations with HSF has a dose-dependent antiproliferative effect on those cells. Cellular proliferation is not effected in Argireline low concentration[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Argireline is applied to the aged mice twice daily for 6 weeks. There is an improvement in the histological structure of skin tissue in the aged mice; the amount of type I collagen fibers increased, while that of type III collagen fibers decreased. Argireline could improve the histological structure of skin tissue and rejuvenate the aging skin[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

888.99

Formula

C34H60N14O12S
CAS 号

616204-22-9
Sequence Shortening

Ac-EEMQRR-NH2
中文名称

六胜肽
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 100 mg/mL (112.49 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1249 mL 5.6244 mL 11.2487 mL
5 mM 0.2250 mL 1.1249 mL 2.2497 mL
10 mM 0.1125 mL 0.5624 mL 1.1249 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Blanes-Mira C, et al. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002 Oct;24(5):303-10.

    [2]. Grosicki M, et al. The study of cellular cytotoxicity of argireline – an anti-aging peptide. Acta Biochim Pol. 2014;61(1):29-32.

    [3]. Wang Y, et al. The anti-wrinkle efficacy of Argireline. J Cosmet Laser Ther. 2013 Aug;15(4):237-41.