Hexa-N-acetylchitohexaose is an inducer of disease resistance in crop plants, which could elicit an increase of lignification-related and antioxidative enzymes in soybean plants. Hexa-N-acetylchitohexaose is a substrate of lysozyme. Hexa-N-acetylchitohexaose shows antitumor effect[1][2][3].
体内研究 (In Vivo)
On sarcoma 180 solid tumor in ddY mice using lentinan, an antitumorβ-D-glucan, as the positive control. Hexa-N-acetylchitohexaose (100 mg/kg/day; 3 times; intravenous ) significantly inhibits the growth of this allogenic solid tumor, affording a high tumor growth-inhibition ratio (85%) at 7 days after tumor implantation[3].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
1237.17
Formula
C48H80N6O31
CAS 号
38854-46-5
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Li K, et al. Access to N-Acetylated Chitohexaose with Well-Defined Degrees of Acetylation. Biomed Res Int. 2017;2017:2486515.
[2]. David C. Phillips. THE HEN EGG-WHITE LYSOZYME MOLECULE. Proc Natl Acad Sci U S A. 1967 Mar; 57(3): 483-495.
[3]. Suzuki K, et al. Antitumor effect of hexa-N-acetylchitohexaose and chitohexaose. Carbohydr Res. 1986;151:403-408.
Hexa-D-arginine TFA;(Synonyms: Furin Inhibitor II TFA)
Hexa-D-arginine TFA (Furin Inhibitor II TFA) 是一种稳定的 furin 抑制剂,对 furin,PACE4 和 PC1 的 Ki 值分别为 106 nM,580 nM 和 13.2 μM。Hexa-D-arginine TFA 在体外和体内均可阻断假单胞菌外毒素 A 和炭疽毒素的毒性。
Hexa-D-arginine TFA Chemical Structure
CAS No. : 958204-56-3
规格
是否有货
100 mg
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询价
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250 mg
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500 mg
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Hexa-D-arginine TFA 的其他形式现货产品:
Hexa-D-arginine
生物活性
Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo[1][2][3].
Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)
Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
1068.17
Formula
C38H76F3N25O8
CAS 号
958204-56-3
Sequence
Arg-Arg-Arg-Arg-Arg-Arg-NH2
Sequence Shortening
RRRRRR-NH2
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9.
[2]. Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72(1):602-5.
[3]. Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9.
[1]. Watly J, et al. Insight into the coordination and the binding sites of Cu(2+) by the histidyl-6-tag using experimental and computational tools. Inorg Chem. 2014 Jul 7;53(13):6675-83.
Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo[1][2][3].
Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)
Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
954.14
Formula
C36H75N25O6
CAS 号
673202-67-0
Sequence Shortening
RRRRRR-NH2
中文名称
六-D-精氨酸
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9.
[2]. Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72(1):602-5.
[3]. Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9.
Hexamethylquercetagetin is a polymethoxylated flavone in peels of citrus cultivars.
分子量
402.39
Formula
C21H22O8
CAS 号
1251-84-9
中文名称
3,5,6,7,3′,4′-六甲氧基黄酮
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Green CO, et al. Determination of polymethoxylated flavones in peels of selected Jamaican and Mexican citrus (Citrus spp.) cultivars by high-performance liquid chromatography. Biomed Chromatogr. 2007 Jan;21(1):48-54.