标签归档：gr

GR 64349 TFA

发表于由

GR 64349 TFA;

GR 64349 是有效的、高度选择性的神经激肽 2 (NK2) 受体的肽类拮抗剂，其在大鼠结肠中测得的EC50 值为 3.7 nM。GR 64349 对 NK1 和 NK3 受体的选择性要低 1000 和 300 倍以上。

GR 64349 TFAamp;;

GR 64349 TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

GR 64349 is a potent and highly selective NK2 receptor peptide antagonist, with an EC50 of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK1 and NK3 receptors, respectively[1][2].

分子量

1035.13

Formula

C44H69F3N10O13S
Sequence Shortening

KDSFV{Aaa}LM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Y Chang, et al. Tachykinin receptor subtypes in the isolated guinea pig heart and their role in mediating responses to neurokinin A. J Pharmacol Exp Ther. 2000 Jul;294(1):147-54.

    [2]. M J Deal, et al. Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists. J Med Chem. 1992 Oct 30;35(22):4195-204.

ALK[G1202R] 品牌：Carna Bio

发表于由

ALK[G1202R]

品牌：Carna Bio
CAS No.：
储存条件：-80℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

382-01673

 – 100 ug – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

GR 94800 TFA

发表于由

GR 94800 TFA;

GR 94800 TFA 是有效的、选择性的神经激肽 2 (NK2) 受体的肽类拮抗剂，其对 NK2、NK1 和 NK3 受体的 pKB 值分别为 9.6、6.4 和 6.0。

GR 94800 TFAamp;;

GR 94800 TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

GR 94800 TFA is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively[1][2].

体外研究
(In Vitro)

Responses to EFS (15 Hz) were significantly reduced by the NK2 receptor antagonist GR 94800 (1 μM) either alone or in combination with the NK1 antagonist (1 μM)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1018.08

Formula

C51H62F3N9O10
Sequence Shortening

Bz-AA-{D-Trp}-F-{D-Pro}-P-{Nle}-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. A B McElroy, et al. Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor. J Med Chem. 1992 Jul 10;35(14):2582-91.

    [2]. M A Matuszek, et al. An investigation of tachykinin NK2 receptor subtypes in the rat. Eur J Pharmacol. 1998 Jul 3;352(1):103-9.

    [3]. Stephen D Tichenor, et al. Excitatory motor innervation in the canine rectoanal region: role of changing receptor populations. Br J Pharmacol. 2002 Dec;137(8):1321-9.

GR231118 TFA(Synonyms: 1229U91 TFA GW1229 TFA)

发表于由

GR231118 TFA;(Synonyms: 1229U91 TFA; GW1229 TFA)

GR231118 是神经肽 Y 的 C 末端的类似物，对人神经肽 Y Y 受体具有较强的竞争性和相对选择性拮抗剂，其拮抗剂的 pKi 为10.4。GR231118 是人类神经肽 Y4 受体 (pEC50=8.6; pKi=9.6) 和对人及大鼠神经肽 YY2 和 Y5 受体的弱激动剂。GR231118 对小鼠神经肽 YY6 受体也有较高亲和力 (pKi= 8.8)。

GR231118 TFAamp;;(Synonyms: 1229U91 TFA; GW1229 TFA)

GR231118 TFA Chemical Structure

规格 是否有货
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250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pKi= 8.8)[1].

分子量

2466.76

Formula

C112H171F3N34O26
Sequence Shortening

Sequence 1:IEP-{Dpr}-YRLRY-NH2;Sequence 1′:IEP-{Dpr}-YRLRY-NH2 (Amide bridge:Glu2-Dpr4′;Dpr4-Glu2′)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. E M Parker, et al. GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Eur J Pharmacol

    [2]. Y Dumont, et al. [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors. Br J Pharmacol. 2000 Jan;129(1):37-46.

GR-73632

发表于由

GR-73632;

GR-73632 是新型速激肽神经激肽1 (NK-1) 受体激动剂。 GR-73632 通过传递瘙痒信号的 NK1 受体直接作用于初级感觉神经元的外周末端。

GR-73632amp;;

GR-73632 Chemical Structure

CAS No. : 133156-06-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist[1]. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals[2].

IC50 Target

IC50: NK-1 receptor[1]
分子量

766.00

Formula

C40H59N7O6S
CAS 号

133156-06-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sakurada C, et al. Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist. Peptides. 1999;20(2):301-4.

    [2]. Costantini VJ, et al. The NK1 receptor antagonist aprepitant attenuates NK1 agonist-induced scratching behaviour in the gerbil after intra-dermal, topical or oral administration. Exp Dermatol. 2015 Apr;24(4):312-4.

GR 64349

发表于由

GR 64349;

GR 64349 是有效的、高度选择性的神经激肽 2 (NK2) 受体的肽类拮抗剂，其在大鼠结肠中测得的EC50 值为 3.7 nM。GR 64349 对 NK1 和NK3 受体的选择性要低1000 和 300 倍以上。

GR 64349amp;;

GR 64349 Chemical Structure

CAS No. : 137593-52-3

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

GR 64349 is a potent and highly selective NK2 receptor peptide antagonist, with an EC50 of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK1 and NK3 receptors, respectively[1][2].

分子量

921.11

Formula

C42H68N10O11S
CAS 号

137593-52-3
Sequence Shortening

KDSFV{Aaa}LM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Y Chang, et al. Tachykinin receptor subtypes in the isolated guinea pig heart and their role in mediating responses to neurokinin A. J Pharmacol Exp Ther. 2000 Jul;294(1):147-54.

    [2]. M J Deal, et al. Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists. J Med Chem. 1992 Oct 30;35(22):4195-204.

GR 82334

发表于由

GR 82334;

GR 82334 是一种有效的、特异性的可逆速激蛋白 NK1 受体 (tachykinin NK1 receptor) 拮抗剂。GR 82334 通过阻断 NK1 受体的作用，抑制大鼠神经肽 P 物质诱导的致敏作用。

GR 82334amp;;

GR 82334 Chemical Structure

CAS No. : 129623-01-4

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist[1]. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats[1].
体内研究
(In Vivo)

GR 82334 (intrathecal administration; 0.1 nmol-1 nmol) excites rats unnary bladder motihty at 1 nmol but not at 0.1 nmol, and the reflex chemonociceptive is reduced by the topical application of capsaicin (4 μg/50 ul)[1].
GR 82334 (10 nM-1 µM; injected between vertebrae L4 and L5) has no effect at 10 nM in neither species, increases heat-induced foot withdrawal latency in mice at doses >100 nM, but no such increase in naked mole-rats, where doses >100 nM evoke a tendency for decreased latency[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 3-6 month-old, male C57BL/6 mice and 6-18 month-old naked mole-rats[2]
Dosage: 10 nM, 100 nM, and 1 µM
Administration: Lntrathecal injection between vertebrae L4 and L5 
Result: Increased heat-induced foot withdrawal latency in mice.

分子量

1386.55

Formula

C69H91N15O16
CAS 号

129623-01-4
Sequence Shortening

{Glp}ADPNKFY-{Aaa}-LW-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. A Lecci,et al.Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions. Life Sci

    [2]. Antje Brand, et al.  Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat.PLoS One. 2010 Dec 21;5(12):e15162.

GR231118(Synonyms: 1229U91 GW1229)

发表于由

GR231118;(Synonyms: 1229U91; GW1229)

GR231118 是神经肽Y 的 C 末端的类似物，对人神经肽 Y Y 受体具有较强的竞争性和相对选择性拮抗剂，其拮抗剂的 pKi 为10.4。GR231118 是人类神经肽 Y4 受体 (pEC50=8.6; pKi=9.6) 和对人及大鼠神经肽 YY2 和 Y5 受体的弱激动剂。GR231118 对小鼠神经肽 YY6 受体也有较高亲和力 (pKi= 8.8)。

GR231118amp;;(Synonyms: 1229U91; GW1229)

GR231118 Chemical Structure

CAS No. : 158859-98-4

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8)[1].

分子量

2352.74

Formula

C110H170N34O24
CAS 号

158859-98-4
Sequence Shortening

Sequence 1:IEP-{Dpr}-YRLRY-NH2;Sequence 1′:IEP-{Dpr}-YRLRY-NH2 (Amide bridge:Glu2-Dpr4′;Dpr4-Glu2′)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. E M Parker, et al. GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Eur J Pharmacol

    [2]. Y Dumont, et al. [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors. Br J Pharmacol. 2000 Jan;129(1):37-46.

GR 94800

发表于由

GR 94800;

GR 94800 是有效的、选择性的神经激肽 2 (NK2) 受体的肽类拮抗剂，其对 NK2、NK1 和 NK3 受体的 pKB 值分别为 9.6、6.4 和 6.0。

GR 94800amp;;

GR 94800 Chemical Structure

CAS No. : 141636-65-9

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

GR 94800 is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively[1][2].

体外研究
(In Vitro)

Responses to EFS (15 Hz) were significantly reduced by the NK2 receptor antagonist GR 94800 (1 μM) either alone or in combination with the NK1 antagonist (1 μM)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

904.06

Formula

C49H61N9O8
CAS 号

141636-65-9
Sequence Shortening

Bz-AA-{D-Trp}-F-{D-Pro}-P-{Nle}-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. A B McElroy, et al. Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor. J Med Chem. 1992 Jul 10;35(14):2582-91.

    [2]. M A Matuszek, et al. An investigation of tachykinin NK2 receptor subtypes in the rat. Eur J Pharmacol. 1998 Jul 3;352(1):103-9.

    [3]. Stephen D Tichenor, et al. Excitatory motor innervation in the canine rectoanal region: role of changing receptor populations. Br J Pharmacol. 2002 Dec;137(8):1321-9.

沃特曼GR 52定量滤纸直径110mm1452-110

发表于由

沃特曼GR 52定量滤纸直径110mm

简要描述：

Whatman定量滤纸是为重量分析和仪器分析中样品制备而设
计的。它们有三种形式来满足你的特别需求。
无灰级：Grade 40~44 <0.007%，Grade 589< 0.01% – 非常
纯的滤纸，是大部分主要分析过滤过程的理想用纸。
硬化低灰：<0.015%， 经过强酸处理去除了微量金属，产
生了高的湿强度和化学抗性，这些滤纸特别适合用于布氏
漏斗，滤纸坚硬的光滑表面使得它很容易回收沉淀物。
硬化无灰：<0.006%，非常低的灰分含量，酸硬化增加了
湿强度和化学抗性。坚硬的表面使得这些滤纸适合于大多
数主要过滤过程。
这些滤纸的zui高灰分含量介于无灰级和定性级之间。特别
适用于布氏漏斗过滤。其坚韧光滑的表面易于回收沉淀物。
其他特性包括高湿强以及化学相容性都类似于硬化无灰级别
Grade 50 : 2.7 μm
可以保留非常细小的结晶物沉淀物，是whatman滤纸中z
薄的一种，流速慢，颗粒保留性好。No.50滤纸目前是世界
范围内钻井液测定用标准滤纸，广泛在石油天然气开
采作业流体实验室应用。食品分析中，与Whatman 1PS相
分离纸配合测定肉食品中的脂肪含量。硬化的表面有效地防
止纤维脱落。非常合适用于布氏漏斗、三件套漏斗真空定
性或者定量过滤。很好的湿强，可以在湿润状态下处理沉
淀刮除。在电子工业领域，是几乎没有纤维脱落的载体，适
用于集成电路。
这个级别也提供用于擦拭试验的涂抹用式样(例如，用于放
射核素污染的表面测试)。

Grade 52 : 7 μm
常规过滤用硬化滤纸，保留能力和流速中等，表面坚韧。
Grade 54 : 22 μm
快流速和高湿强使得这个级别非常适用于快速真空过滤去
除难滤的粗颗粒和过滤胶状沉淀，如饲料中乙基羟基喹宁。

沃特曼GR 52定量滤纸直径110mm​ 1452-110

沃特曼GR 52定量滤纸直径110mm1452-110