标签归档：fibrils

(ALPHA)-Synuclein Fibrils α-突触核蛋白原纤维 品牌：Cosmo Bio

发表于由

(ALPHA)-Synuclein Fibrils

α-突触核蛋白原纤维

品牌：Cosmo Bio
CAS No.：
储存条件：+4℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

CSR-SYN03-COS

 – 0.1 mg –

(ALPHA)-Synuclein Fibrils α-突触核蛋白原纤维 品牌：Cosmo Bio

替代品：CSR-SYN03

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

K114

发表于由

K114;

K114，一种刚果红染料类似物，与淀粉样纤维 (amyloid fibrils) 紧密结合，其 EC50 值为 20-30 nM。K114 是一种高效的精液源性病毒感染增强剂 (SEVI) 检测剂。

K114amp;;

K114 Chemical Structure

CAS No. : 872201-12-2

规格 价格 是否有货
2 mg ￥1100 询问价格 货期
5 mg ￥2200 询问价格 货期

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生物活性

K114, a fluorescent Congo Red analogue, binds tightly to amyloid fibrils with an EC50 of 20-30 nM[1]. K114 is an efficient detector of semen-derived enhancer of virus infection (SEVI)[2].

体外研究
(In Vitro)

K114’s unusually low buffer fluorescence is due to self-quenching in sedimentable aggregates or micelles which upon interacting with amyloid fibrils undergo an enhancement in fluorescence intensity and shifts in the excitation and emission spectra[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

393.27

Formula

C22H17BrO2
CAS 号

872201-12-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 100 mg/mL (254.28 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5428 mL 12.7139 mL 25.4278 mL
5 mM 0.5086 mL 2.5428 mL 5.0856 mL
10 mM 0.2543 mL 1.2714 mL 2.5428 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. LeVine H 3rd, et al. Mechanism of A beta(1-40) fibril-induced fluorescence of (trans,trans)-1-bromo-2,5-bis(4-hydroxystyryl)benzene (K114). Biochemistry. 2005 Dec 6;44(48):15937-43.

    [2]. Selmani V, et al. K114 (trans, trans)-bromo-2,5-bis(4-hydroxystyryl)benzene is an efficient detector of cationic amyloid fibrils. Protein Sci. 2015 Mar;24(3):420-5.