[1]. Li S, et al. Development of a method to screen and isolate potential xanthine oxidase inhibitors from Panax japlcus var via ultrafiltration liquid chromatography combined with counter-current chromatography. Talanta. 2015 Mar;134:665-73.
[2]. He R, et al. Chemical constituents of leaves of Panax japonicus var. major. Zhongguo Zhong Yao Za Zhi. 2014 May;39(9):1635-8.
Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum[1].
体内研究 (In Vivo)
Apraglutide (FE 203799; 5 mg/kg/dose, subcutaneously, twice on days 0 and 4 postsurgery) treated piglets are healthy, have significant lower fecal fat and energy losses and exhibite intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth on day 7[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
NewbornDuroc piglets, 2–5 days old and weighing between 2-2.6 kg[1].
Dosage:
5 mg/kg/dose.
Administration:
Subcutaneously, twice on days 0 and 4 postsurgery.
Result:
On day 7, treated piglets were healthy, had significant lower fecal fat and energy losses and exhibited intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth.
Clinical Trial
分子量
3765.25
Formula
C172H263N43O52
CAS 号
1295353-98-8
Sequence Shortening
HGDGSFSDEX FTILDLLAAR DFINWLIQTK ITD-NH2
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-80deg;C
2 years
-20deg;C
1 year
In solvent
-80deg;C
6 months
-20deg;C
1 month
参考文献
[1]. Slim GM, et al. Novel Long-Acting GLP-2 Analogue, FE 203799 (Apraglutide), Enhances Adaptation and Linear Intestinal Growth in a Neonatal Piglet Model of Short Bowel Syndrome with Total Resection of the Ileum. JPEN J Parenter Enteral Nutr. 2019 Jan 6.