标签归档：fad

Flavin adenine dinucleotide disodium salt(Synonyms: 黄素腺嘌呤二核苷酸二钠; FAD disodium salt; FAD-Na2)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Flavin adenine dinucleotide disodium salt;(Synonyms: 黄素腺嘌呤二核苷酸二钠; FAD disodium salt; FAD-Na2) 纯度: 99.84%

Flavin adenine dinucleotide (FAD) disodium salt 是一种氧化还原辅因子，蛋白质的辅基，在代谢过程中参与了几个重要的酶反应。

Flavin adenine dinucleotide disodium salt(Synonyms: 黄素腺嘌呤二核苷酸二钠; FAD disodium salt; FAD-Na2)

Flavin adenine dinucleotide disodium salt Chemical Structure

CAS No. : 84366-81-4

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ￥847 In-stock
25 mg ￥770 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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生物活性

Flavin adenine dinucleotide (FAD) disodium salt is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

IC50 Target

Human Endogenous Metabolite

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体外研究
(In Vitro)

Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10-3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

With Flavin adenine dinucleotide (2 mg/kg), the chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT) is significantly cancelled. Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

829.51

Formula

C27H31N9Na2O15P2
CAS 号

84366-81-4
中文名称

黄素腺嘌呤二核苷酸二钠
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture and light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro:;

H2O : 33.33 mg/mL (40.18 mM; Need ultrasonic)

DMSO : 5 mg/mL (6.03 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2055 mL 6.0277 mL 12.0553 mL
5 mM 0.2411 mL 1.2055 mL 2.4111 mL
10 mM 0.1206 mL 0.6028 mL 1.2055 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Sugiyama S, et al. Protection of chlorpromazine-induced arrhythmia by flavin-adenine-dinucleotide in canine heart. Jpn Heart J. 1979 Sep;20(5):657-65.

    [2]. Karyakin AA, et al. Electropolymerized flavin adenine dinucleotide as an advanced NADH transducer. Anal Chem. 2004 Apr 1;76(7):2004-9.