生化分析试剂 Biochemical Assay Reagents
Cremophor EL;(Synonyms: 聚氧乙烯蓖麻油EL)
Cremophor EL 是一种聚氧乙烯蓖麻油衍生物，是一种非离子表面活性剂。Cremophor EL 被广泛用于改善药物的溶解和输送。
Cremophor EL Chemical Structure
CAS No. : 61791-12-6
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 100 mL | ￥800 | In-stock | |
| 200 mL | ; | 询价 | ; |
| 500 mL | ; | 询价 | ; |
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| 生物活性 |
Cremophor EL, a polyoxyethylene castor oil derivative, is a nonionic surfactant. Cremophor EL is widely employed to improve dissolution and delivery of drugs[1]. |
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| 体外研究 (In Vitro) |
Cremophor EL is a widely used excipient. In the first 10 h, Cremophor EL at 5 mg/mL increases the impedance, then decreases it, and after 20 h of treatment, epithelial cell death is detected. Cremophor EL decreases cell viability and increases cell toxicity more than RH40. Both epithelial viability and monolayer integrity are seriously impaired at 10 to 50 mg/mL concentrations of Cremophor EL at 24-h treatment. Cremophor EL also enhances cell detachment[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS 号 |
61791-12-6 |
| 中文名称 |
聚氧乙烯蓖麻油EL |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
4deg;C, protect from light |
| 溶解性数据 |
In Vitro:;
Ethanol : 50 mg/mL (Need ultrasonic) H2O : 25 mg/mL (Need ultrasonic) |
| 参考文献 |
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| Cell Assay [1] |
Cell viability is determined by double fluorescent staining: bis-benzimide labels all cell nuclei, ethidium-homodimer-1 stains only dead cells. For morphological examinations, primary brain endothelial cells with tight barrier properties are used. Cells grown on glass coverslips are treated with Cremophor EL and RH40 for 1 and 24 h. Cremophor EL and RH40 are tested at 0.1 to 50 mg/mL concentrations. Triton X-100 detergent (10 mg/mL) is used in toxicity assays as a reference compound to cause cell death[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 参考文献 |
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