Ganoderic acid DM(Synonyms: 灵芝酸 DM)

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Ganoderic acid DM (Synonyms: 灵芝酸 DM) 纯度: 99.65%

Ganoderic acid DM 是可从 Ganoderma lucidum 分离得到的一个天然三萜,可诱导人乳腺癌细胞的 DNA 损伤、G1 细胞周期阻滞和凋亡。Ganoderic acid DM 还是破骨形成的特异性抑制剂。

Ganoderic acid DM(Synonyms: 灵芝酸 DM)

Ganoderic acid DM Chemical Structure

CAS No. : 173075-45-1

规格 价格 是否有货 数量
1 mg ¥3840 In-stock
5 mg ¥11600 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Ganoderic acid DM 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis[1][2].

体外研究
(In Vitro)

Ganoderic acid DM (GADM) effectively inhibits cell proliferation and colony formation in MCF-7 human breast cancer cells, which was much stronger than that of MDA-MB-231 breast cancer cells[1].
Ganoderic acid DM especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1). Ganoderic acid DM markedly suppressed the expression of cathepsin K and TRAP mRNA[2].
Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MCF-7 and MDA-MB-231 cells.
Concentration: 0-100 μM.
Incubation Time: 48 h.
Result: Decreased the cell viability in breast cancer cells.

Cell Viability Assay[2]

Cell Line: RAW-D cells.
Concentration: 0-100 μg/mL.
Incubation Time: 0-100 μg/mL.
Result: Clearly suppressed osteoclastogenesis from the RAW 264 cell D-clone.

分子量

468.67

Formula

C30H44O4

CAS 号

173075-45-1

中文名称

灵芝酸 DM

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献
  • [1]. Guo-Sheng Wu, et al. Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia. 2012 Mar;83(2):408-14.

    [2]. Ichiko Miyamoto, et al. Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum. Eur J Pharmacol. 2009 Jan 5;602(1):1-7.

    [3]. Junbo Xia, et al. Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity. Chem Biol Interact. 2020 Jan 25;316:108932.

Research Diets动物饲料D12042201M Formula 模型饲料配方表

上海金畔生物科技有限公司代理Research Diets品牌动物饲料全线产品,欢迎访问官网了解更多产品信息。
Research Diets动物饲料D12042201M Formula 模型饲料配方表

D12042201M

High-Fat Diet With 41 kcal% Fat (Butter) With 2% Cholesterol

适用实验动物模型: 啮齿类 (大鼠/小鼠)
饲料颜色: 红色
是否辐照处理/辐照产品号码 :

Research Diets生产饲料大部分都可以送伽马辐照。我们会在这类的产品号结尾标注 “i” 字母以说明其为通过辐照处理的饲料,而饲料经过多轮辐照处理则会标示双字母 “ii” 以区别单轮辐照 “i”。如果您有任何关于辐照的问题,请联系我们的科研技术支持。

纯化饲料配方表

营养成分类别 成分 公克
蛋白质 酪蛋白(乳酸; 30筛孔) 200.00 克
蛋白质 Methionine, DL 3.00 克
碳水化合物 Fructose 301.00 克
碳水化合物 麦芽糊精 125.00 克
碳水化合物 玉米淀粉 50.00 克
纤维素 纤维素(Solka Floc/FCC200) 50.00 克
脂肪 Butter, Anhydrous (GrassLand) 200.00 克
矿物质 S10001 35.00 克
矿物质 碳酸钙, light(USP) 4.00 克
维他命 V10001 10.00 克
维他命 酒石酸胆碱 2.00 克
抗氧化剂 Ethoxyquin 0.04 克
特殊成分 Cholesterol, NF 20.00 克
染色剂 染料,红色FD&C #40,Alum. Lake 35-42% 0.05 克
饲料配方总重(公克): 1000.09 克